Results 1 to 10 of about 1,350,887 (263)

NMDA receptor inhibition increases, synchronizes, and stabilizes the collective pancreatic beta cell activity: Insights through multilayer network analysis.

PLoS Computational Biology, 2021
NMDA receptors promote repolarization in pancreatic beta cells and thereby reduce glucose-stimulated insulin secretion. Therefore, NMDA receptors are a potential therapeutic target for diabetes.
Marko Šterk, Lidija Križančić Bombek, Maša Skelin Klemen, Marjan Slak Rupnik, Marko Marhl, Andraž Stožer, Marko Gosak   +6 more
doaj   +1 more source

Functional Proteins Involved in Regulation of Intracellular Ca2+ for Drug Development: Desensitization of N-Methyl-D-aspartate Receptor Channels

Journal of Pharmacological Sciences, 2005
N-Methyl-D-aspartate (NMDA) receptors are a principal subtype of excitatory ligand-gated ion channels with crucial roles in a variety of physiological and pathological processes in the mammalian central nervous system (CNS).
Noritaka Nakamichi, Yukio Yoneda
doaj   +1 more source

Enhanced synaptic long-term potentiation in the anterior cingulate cortex of adult wild mice as compared with that in laboratory mice

Molecular Brain, 2009
Activation of N-methyl D-aspartate (NMDA) receptor is important for learning, memory and persistent pain. Genetic enhancement of NMDA receptor function by overexpressing NR2B subunit significantly enhances hippocampal long-term potentiation (LTP ...
Zhao Ming-Gao, Toyoda Hiroki, Wang Yu-Kun, Zhuo Min   +3 more
doaj   +1 more source

Activation of NMDA receptors in brain endothelial cells increases transcellular permeability

Fluids and Barriers of the CNS, 2022
Neurovascular coupling is a precise mechanism that induces increased blood flow to activated brain regions, thereby providing oxygen and glucose.
Kyu-Sung Kim, Min Tae Jeon, Eun Seon Kim, Chan Hee Lee, Do-Geun Kim   +4 more
doaj   +1 more source

Age-Dependent, Subunit Specific Action of Hydrogen Sulfide on GluN1/2A and GluN1/2B NMDA Receptors

Frontiers in Cellular Neuroscience, 2017
Hydrogen sulfide (H2S) is an endogenously produced neuroactive gas implicated in many key processes in the peripheral and central nervous system. Whereas the neuroprotective role of H2S has been shown in adult brain, the action of this messenger in ...
Aleksey V. Yakovlev, Evgeniya D. Kurmasheva, Yevheniia Ishchenko, Rashid Giniatullin, Rashid Giniatullin, Guzel F. Sitdikova   +5 more
doaj   +1 more source

Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation

Neurobiology of Disease, 2003
We analyzed NMDA receptor subunit mRNAs, proteins, and anchoring proteins in mice transgenic for exon 1 of the HD gene. R6/2 mice had decreased levels of mRNAs encoding ε1 and ε2 NMDA receptor subunits (mouse orthologs of rat NR2A and NR2B subunits), but
Ruth Luthi-Carter, Barbara L Apostol, Anthone W Dunah, Molly M DeJohn, Laurie A Farrell, Gillian P Bates, Anne B Young, David G Standaert, Leslie M Thompson, Jang-Ho J Cha   +9 more
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Dual regulation by ethanol of the inhibitory effects of ketamine on spinal NMDA-induced pressor responses in rats

Journal of Biomedical Science, 2012
Background Acute exposure of ethanol (alcohol) inhibits NMDA receptor function. Our previous study showed that acute ethanol inhibited the pressor responses induced by NMDA applied intrathecally; however, prolonged ethanol exposure may increase the ...
Keng Nien-Tzu, Lin Hsun-Hsun, Lin Huei-Ru, Hsieh Wei-Kung, Lai Chih-Chia   +4 more
doaj   +1 more source

Anti-NMDA-receptor antibody encephalitis in infants

Epilepsy and Behavior Case Reports, 2015
Purpose: Anti-N-methyl-d-aspartate (NMDA) receptor antibody encephalitis is an autoimmune disorder manifesting subacutely with prominent aberrant movements and psychiatric symptoms.
Amr A. Matoq, Adam S. Rappoport, Yiting Yang, Jessica O'Babatunde, Rubina Bakerywala, Raj D. Sheth   +5 more
doaj   +1 more source

Homocysteic acid and the potential role of N-methyl-D-aspartate receptors in cosmetic dermatology: a review

Journal of Cosmetic Medicine
Recent advances in neurocutaneous research have revealed that N-methyl-D-aspartate (NMDA) receptors, which are traditionally associated with neural signaling, play significant roles in skin physiology.
JinHan Lee, Junhwan Jung, Hyungin Cho, Ingyu Lee   +3 more
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Action of GABAB receptor on local network oscillation in somatosensory cortex of oral part: focusing on NMDA receptor

Journal of Physiological Sciences
The balance of activity between glutamatergic and GABAergic networks is particularly important for oscillatory neural activities in the brain. Here, we investigated the roles of GABAB receptors in network oscillation in the oral somatosensory cortex (OSC)
Hiroyuki Kanayama, Takashi Tominaga, Yoko Tominaga, Nobuo Kato, Hiroshi Yoshimura   +4 more
doaj   +1 more source