Results 11 to 20 of about 1,350,887 (263)

Ofatumumab Therapy and Long-Term Seizure Outcomes of Patients With Relapsing Anti-NMDA Receptor Encephalitis. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective There is a lack of studies on seizure outcomes associated with ofatumumab therapy in patients for relapsing anti‐N‐methyl‐D‐aspartate (NMDA) receptor encephalitis. We aimed to evaluate long‐term seizure outcomes of ofatumumab therapy for relapsing anti‐NMDA receptor encephalitis.
Wang J, Li M, Kong P.
europepmc   +2 more sources

Treatment of Cerebral Ischemia Through NMDA Receptors: Metabotropic Signaling and Future Directions

Frontiers in Pharmacology, 2022
Excessive activation of N-methyl-d-aspartic acid (NMDA) receptors after cerebral ischemia is a key cause of ischemic injury. For a long time, it was generally accepted that calcium influx is a necessary condition for ischemic injury mediated by NMDA ...
Yuanyuan Li, Xiaokun Cheng, Xiaokun Cheng, Xiaokun Cheng, Xiaokun Cheng, Xinying Liu, Le Wang, Le Wang, Jing Ha, Jing Ha, Jing Ha, Zibin Gao, Zibin Gao, Zibin Gao, Xiaoliang He, Zhuo Wu, Aibing Chen, Linda L. Jewell, Yongjun Sun, Yongjun Sun, Yongjun Sun   +20 more
doaj   +1 more source

Targeted NMDA Receptor Interventions for Autism: Developmentally Determined Expression of GluN2B and GluN2A-Containing Receptors and Balanced Allosteric Modulatory Approaches

Biomolecules, 2022
Various ASD risk alleles have been associated with impairment of NMDA receptor activation (i.e., NMDA Receptor Hypofunction) and/or disturbance of the careful balance between activation mediated by GluN2B-subtype and GluN2A-subtype-containing NMDA ...
Stephen I. Deutsch, Zachary N. M. Luyo, Jessica A. Burket   +2 more
doaj   +1 more source

Bortezomib in the management of anti-NMDA receptor encephalitis

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2023
Background Anti-N-methyl d-aspartate (NMDA) receptor encephalitis is an autoimmune encephalitis characterized by neuronal surface antibodies targeting NMDA receptor in the spinal fluid and serum.
Bryan Gervais de Liyis, Jane Carissa Sutedja, Maria Pramesthi Sabrina Evananda, Ledwin Meikel Wibisono, Chrysanta Paramitha Karuniamaya, Cindy Thiovany Soetomo, Ni Made Susilawathi   +6 more
doaj   +1 more source

COVID−19, Anti-NMDA Receptor Encephalitis and MicroRNA

Frontiers in Immunology, 2022
The coronavirus disease 2019 (COVID-19) pandemic has had an enormous impact on the world, affecting people’s lifestyle, economy, and livelihood. Recently, with the development of vaccines, the number of infected cases has decreased.
Hsiuying Wang
doaj   +1 more source

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis [PDF]

Advanced science
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Yan L, Zhang E, Ma Y, Meng Z, Li S, Ren Y, Tian X, He Y, Battaglia G, Zhou D, Liao Y, Ying B, Li J, Wang M.   +13 more
europepmc   +2 more sources

Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats

Journal of Pharmacological Sciences, 2006
.: Generalizations of NMDA-receptor antagonists to the discriminative stimulus effects of κ-opioid receptor agonists in rats were examined. Phencyclidine, MK-801, and ketamine, noncompetitive NMDA-receptor antagonists, generalized to the discriminative ...
Tomohisa Mori, Mutsuko Nomura, Kazumi Yoshizawa, Hiroshi Nagase, Toshiko Sawaguchi, Minoru Narita, Tsutomu Suzuki   +6 more
doaj   +1 more source

NMDA Receptor Modulators in the Treatment of Drug Addiction

Pharmaceuticals, 2013
Glutamate plays a pivotal role in drug addiction, and the N-methyl-D-aspartate (NMDA) glutamate receptor subtype serves as a molecular target for several drugs of abuse. In this review, we will provide an overview of NMDA receptor structure and function,
M. Foster Olive, Natali E. Nemirovsky, Seven E. Tomek, Amber L. Lacrosse   +3 more
doaj   +1 more source

Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits [PDF]

, 2003
The subunits that compose eukaryotic glutamate ion channel receptors have three transmembrane domains (TMs) and terminate with intracellular tails that are important for controlling channel expression and localization.
Schorge, S., David Colquhoun, Colquhoun, D., Stephanie Schorge   +3 more
core   +1 more source

N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors

Alzheimer’s Research & Therapy, 2021
Background The cannabinoid CB2 receptor (CB2R), which is a target to afford neuroprotection, and N-methyl-D-aspartate (NMDA) ionotropic glutamate receptors, which are key in mediating excitatory neurotransmission, are expressed in both neurons and glia ...
Rafael Rivas-Santisteban, Alejandro Lillo, Jaume Lillo, Joan-Biel Rebassa, Joan S. Contestí, Carlos A. Saura, Rafael Franco, Gemma Navarro   +7 more
doaj   +1 more source