Results 11 to 20 of about 114,424 (204)

Allosteric Inhibitors of NMDA Receptor Functions

Pharmaceuticals, 2010
NMDA receptors are glutamate-activated ion-channels involved in many essential brain functions including learning, memory, cognition, and behavior. Given this broad range of function it is not surprising that the initial attempts to correct NMDA receptor-
William F. Borschel, Gabriela K. Popescu, Swetha Murthy   +2 more
doaj   +2 more sources

Anti-NMDA-receptor antibody encephalitis in infants

Epilepsy and Behavior Case Reports, 2015
Purpose: Anti-N-methyl-d-aspartate (NMDA) receptor antibody encephalitis is an autoimmune disorder manifesting subacutely with prominent aberrant movements and psychiatric symptoms.
Amr A. Matoq, Adam S. Rappoport, Yiting Yang, Jessica O'Babatunde, Rubina Bakerywala, Raj D. Sheth   +5 more
doaj   +2 more sources

A quantitative method to assess extrasynaptic NMDA receptor function in the protective effect of synaptic activity against neurotoxicity

BMC Neuroscience, 2008
Background Extrasynaptic NMDA receptors couple to a CREB shut-off pathway and cause cell death, whereas synaptic NMDA receptors and nuclear calcium signaling promote CREB-mediated transcription and neuronal survival.
Bading Hilmar, Dick Oliver, Bengtson C Peter   +2 more
doaj   +1 more source

GluN2B-NMDAR subunit contribution on synaptic plasticity: A phenomenological model for CA3-CA1 synapses

Frontiers in Synaptic Neuroscience, 2023
Synaptic plasticity is believed to be a key mechanism underlying learning and memory. We developed a phenomenological N-methyl-D-aspartate (NMDA) receptor-based voltage-dependent synaptic plasticity model for synaptic modifications at hippocampal CA3-CA1
Justinas J. Dainauskas, Justinas J. Dainauskas, Hélène Marie, Michele Migliore, Ausra Saudargiene   +4 more
doaj   +1 more source

Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes [PDF]

, 2011
Background and purpose Astrocytes of the mouse neocortex express functional NMDA receptors which are not blocked by Mg2+ions. However, study of the pharmacological profile of glial NMDARs and their subunit composition is far from complete ...
Lalo, Ulyana, Pankratov, Yuriy, Palygin, Oleg, Oleg Palygin, Ulyana Lalo, Yuriy Pankratov   +5 more
core   +1 more source

Dynamin-dependent NMDAR endocytosis during LTD and its dependence on synaptic state

BMC Neuroscience, 2005
Background The N-methyl-D-aspartate (NMDA)-type glutamate receptor expressed at excitatory glutamatergic synapses is required for learning and memory and is critical for normal brain function.
Hanson Jesse E, Selcher Joel C, Montgomery Johanna M, Madison Daniel V   +3 more
doaj   +1 more source

Dissecting the contribution of individual receptor subunits to the enhancement of N-methyl-D-aspartate currents by dopamine D1 receptor activation in striatum

Frontiers in Systems Neuroscience, 2011
Dopamine, via activation of D1 receptors, enhances N-methyl-D-aspartate (NMDA) receptor-mediated responses in striatal medium-sized spiny neurons. However, the role of specific NMDA receptor subunits in this enhancement remains unknown.
Emily L Jocoy, Véronique M André, Damian M Cummings, Shilpa P Rao, Nanping eWu, Amy J Ramsey, Marc G Caron, Carlos eCepeda, Michael S Levine   +8 more
doaj   +1 more source

Hippocampal glutamate NMDA receptor loss tracks progression in Alzheimer's disease: quantitative autoradiography in postmortem human brain. [PDF]

PLoS ONE, 2013
Early Alzheimer's disease (AD) is characterized by memory loss and hippocampal atrophy with relative sparing of basal ganglia. Activation of glutamate NMDA receptors in the hippocampus is an important step in memory formation.
Efrat Kravitz, Inna Gaisler-Salomon, Anat Biegon   +2 more
doaj   +1 more source

Absence of whisker-related pattern formation in mice with NMDA receptors lacking coincidence detection properties and calcium signaling [PDF]

, 2003
Precise refinement of synaptic connectivity is the result of activity-dependent mechanisms in which coincidence-dependent calcium signaling by NMDA receptors (NMDARs) under control of the voltage-dependent Mg2+ block might play a special role.In the ...
Tigaret, Cezar M., Hunt, S.P., Roes, Juergen, Roes, J, Isabel Dean, Alexander J. Annala, Schoepfer, Ralf, Gibb, AJ, Dean, I., Dean, I, Chen, P.E., Rast, GF, Kneussel, Matthias, Annala, AJ, Annala, A.J., Hunt, Stephen P., Roes, J., Rudhard, York, Rudhard, Y., Gibb, A.J., Rudhard, Y, Tigaret, C.M., Philip E. Chen, Dean, Isabel, Schoepfer, R, Schoepfer, R., York Rudhard, Chen, PE, Gibb, Alasdair J., Stephen P. Hunt, Matthias Kneussel, Tigaret, CM, Kneussel, M., Cezar M. Tigaret, Juergen Roes, Nassar, MA, Rast, Georg F., Ralf Schoepfer, Rast, G.F., Mohammed A. Nassar, Annala, Alexander J., Nassar, Mohammed A., Georg F. Rast, Alasdair J. Gibb, Kneussel, M, Hunt, SP, Nassar, M.A., Chen, Philip E.   +47 more
core   +1 more source

mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway

Journal of Biomedical Science, 2011
Background In order to understand the interaction between the metabotropic glutamate subtype 5 (mGluR5) and N-methyl-D-aspartate (NMDA) receptors, the influence of mGluR5 positive modulators in the inhibition of NMDA receptors by the noncompetitive ...
Liao Pei-Fei, Chen Hwei-Hsien, Chan Ming-Huan   +2 more
doaj   +1 more source