Results 11 to 20 of about 187,345 (313)

GluN2B-NMDAR subunit contribution on synaptic plasticity: A phenomenological model for CA3-CA1 synapses

Frontiers in Synaptic Neuroscience, 2023
Synaptic plasticity is believed to be a key mechanism underlying learning and memory. We developed a phenomenological N-methyl-D-aspartate (NMDA) receptor-based voltage-dependent synaptic plasticity model for synaptic modifications at hippocampal CA3-CA1
Justinas J. Dainauskas, Justinas J. Dainauskas, Hélène Marie, Michele Migliore, Ausra Saudargiene   +4 more
doaj   +1 more source

The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration [PDF]

, 2015
NMDA Receptors (NMDA-Rs) are ionotropic glutamate receptors, which associate with LDL Receptor-related Protein-1 (LRP1) to trigger cell-signaling in response to protein ligands in neurons.
Campana, W. Marie, Gonias, Steven L., Lam, Michael S, Mantuano, Elisabetta, Shibayama, Masataka   +4 more
core   +2 more sources

Dissecting the contribution of individual receptor subunits to the enhancement of N-methyl-D-aspartate currents by dopamine D1 receptor activation in striatum

Frontiers in Systems Neuroscience, 2011
Dopamine, via activation of D1 receptors, enhances N-methyl-D-aspartate (NMDA) receptor-mediated responses in striatal medium-sized spiny neurons. However, the role of specific NMDA receptor subunits in this enhancement remains unknown.
Emily L Jocoy, Véronique M André, Damian M Cummings, Shilpa P Rao, Nanping eWu, Amy J Ramsey, Marc G Caron, Carlos eCepeda, Michael S Levine   +8 more
doaj   +1 more source

Hippocampal glutamate NMDA receptor loss tracks progression in Alzheimer's disease: quantitative autoradiography in postmortem human brain. [PDF]

PLoS ONE, 2013
Early Alzheimer's disease (AD) is characterized by memory loss and hippocampal atrophy with relative sparing of basal ganglia. Activation of glutamate NMDA receptors in the hippocampus is an important step in memory formation.
Efrat Kravitz, Inna Gaisler-Salomon, Anat Biegon   +2 more
doaj   +1 more source

Inhibition of Food Intake by PACAP in the Hypothalamic Ventromedial Nuclei is Mediated by NMDA Receptors [PDF]

, 2014
Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the
Choi, Sujean, Maunze, Brian, Phillips, Kailynn A., Resch, Jon M   +3 more
core   +2 more sources

Dynamin-dependent NMDAR endocytosis during LTD and its dependence on synaptic state

BMC Neuroscience, 2005
Background The N-methyl-D-aspartate (NMDA)-type glutamate receptor expressed at excitatory glutamatergic synapses is required for learning and memory and is critical for normal brain function.
Hanson Jesse E, Selcher Joel C, Montgomery Johanna M, Madison Daniel V   +3 more
doaj   +1 more source

Modulating synaptic NMDA receptors [PDF]

Neuropharmacology, 2017
Recent structural information on ligand-gated glutamate receptors and newly-discovered clinical uses for NMDA receptor antagonists has renewed interest in understanding the mechanisms of drug action at these receptors. Although the voltage-dependence and calcium permeability of NMDA receptors are well-studied, the mechanisms affecting the time course ...
Kenneth R, Tovar, Gary L, Westbrook
openaire   +2 more sources

Glutamate-induced depression of EPSP–spike coupling in rat hippocampal CA1 neurons and modulation by adenosine receptors [PDF]

, 2010
The presence of high concentrations of glutamate in the extracellular fluid following brain trauma or ischaemia may contribute substantially to subsequent impairments of neuronal function.
Alici, Andersen, Baratte, Bazhenov, Behan, Benveniste, Bernard, Bernard, Brunedge, Canhão, Carlier, Cash, Clement, Connick, Costenla, Coulter, Cunha, Cunha, Cunha, Cunha, Dahl, Daoudal, Davies, de Mendonça, de Mendonça, de Mendonça, Englund, Ferguson, Fontinha, Forghani, Frenguelli, Frenguelli, Fujii, Fujii, Greiner, Heurteaux, Hoehn, Hülsmann, Jester, Jones, Kitagawa, Klishin, Kukley, Latini, Latini, Lau, Lee, Limbrick, Liu, Lopes, Macgregor, Manzoni, Moore, Nikbakht, Nishizawa, O’Kane, O’Kane, Pedata, Perez-Pinzon, Pugliese, Pugliese, Ribeiro, Schubert, Schurr, Sebastião, Sebastião, Sekino, Sperlagh, Stone, Stone, Szatkowski, Taube, Vizi, Von Lubitz, Wall, Wallis, Wirkner, Wirkner   +77 more
core   +1 more source

GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors in dorsomedial hypothalamus and heart rate in rats [PDF]

, 1991
We have previously shown that microinjection of drugs that interfere with the function of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) into the hypothalamus produces cardiorespiratory and behavioral changes resembling those seen in ...
DiMicco, Joseph A., Soltis, Robert P.
core   +2 more sources

mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway

Journal of Biomedical Science, 2011
Background In order to understand the interaction between the metabotropic glutamate subtype 5 (mGluR5) and N-methyl-D-aspartate (NMDA) receptors, the influence of mGluR5 positive modulators in the inhibition of NMDA receptors by the noncompetitive ...
Liao Pei-Fei, Chen Hwei-Hsien, Chan Ming-Huan   +2 more
doaj   +1 more source