Results 31 to 40 of about 1,350,887 (263)

Allosteric Inhibitors of NMDA Receptor Functions

Pharmaceuticals, 2010
NMDA receptors are glutamate-activated ion-channels involved in many essential brain functions including learning, memory, cognition, and behavior. Given this broad range of function it is not surprising that the initial attempts to correct NMDA receptor-
William F. Borschel, Gabriela K. Popescu, Swetha Murthy   +2 more
doaj   +1 more source

Synaptic NR2A- but not NR2B-containing NMDA receptors increase with blockade of ionotropic glutamate receptors

Frontiers in Molecular Neuroscience, 2009
NMDA receptors are key molecules involved in physiological and pathophysiological brain processes such as plasticity and excitotoxicity. Neuronal activity regulates NMDA receptor levels in the cell membrane.
Jakob Von Engelhardt, Beril Doganci, Peter H Seeburg, Hannah Monyer   +3 more
doaj   +1 more source

Glycine Potentiates AMPA Receptor Function through Metabotropic Activation of GluN2A-containing NMDA Receptors

Frontiers in Molecular Neuroscience, 2016
NMDA receptors are Ca2+-permeable ion channels. The activation of NMDA receptors requires agonist glutamate and co-agonist glycine. Recent evidence indicates that NMDA receptor also has metabotropic function.
Li-Jun Li, Rong Hu, Rong Hu, Brendan Lujan, Juan Chen, Jian-Jian Zhang, Yasuko Nakano, Tian-Yuan Cui, Ming-Xia Liao, Jin-Cao Chen, Hengye Man, Hua Feng, Qi Wan, Qi Wan, Qi Wan, Qi Wan   +15 more
doaj   +1 more source

Non-ionotropic signaling by the NMDA receptor: controversy and opportunity [version 1; referees: 2 approved]

F1000Research, 2016
Provocative emerging evidence suggests that the N-methyl-D-aspartate (NMDA) receptor can signal in the absence of ion flux through the receptor. This non-ionotropic signaling is thought to be due to agonist-induced conformational changes in the receptor,
John A. Gray, Karen Zito, Johannes W. Hell   +2 more
doaj   +1 more source

Absence of whisker-related pattern formation in mice with NMDA receptors lacking coincidence detection properties and calcium signaling [PDF]

, 2003
Precise refinement of synaptic connectivity is the result of activity-dependent mechanisms in which coincidence-dependent calcium signaling by NMDA receptors (NMDARs) under control of the voltage-dependent Mg2+ block might play a special role.In the ...
Tigaret, Cezar M., Hunt, S.P., Roes, Juergen, Roes, J, Isabel Dean, Alexander J. Annala, Schoepfer, Ralf, Gibb, AJ, Dean, I., Dean, I, Chen, P.E., Rast, GF, Kneussel, Matthias, Annala, AJ, Annala, A.J., Hunt, Stephen P., Roes, J., Rudhard, York, Rudhard, Y., Gibb, A.J., Rudhard, Y, Tigaret, C.M., Philip E. Chen, Dean, Isabel, Schoepfer, R, Schoepfer, R., York Rudhard, Chen, PE, Gibb, Alasdair J., Stephen P. Hunt, Matthias Kneussel, Tigaret, CM, Kneussel, M., Cezar M. Tigaret, Juergen Roes, Nassar, MA, Rast, Georg F., Ralf Schoepfer, Rast, G.F., Mohammed A. Nassar, Annala, Alexander J., Nassar, Mohammed A., Georg F. Rast, Alasdair J. Gibb, Kneussel, M, Hunt, SP, Nassar, M.A., Chen, Philip E.   +47 more
core   +1 more source

Blockade of the N-Methyl-D-Aspartate Glutamate Receptor Ameliorates Lipopolysaccharide-Induced Renal Insufficiency.

PLoS ONE, 2015
N-methyl-D-aspartate (NMDA) receptor activation in rat kidney reduces renal perfusion and ultrafiltration. Hypoperfusion-induced ischemia is the most frequent cause of functional insufficiency in the endotoxemic kidney.
Chian-Shiung Lin, Shun-Fa Hung, Ho-Shiang Huang, Ming-Chieh Ma   +3 more
doaj   +1 more source

The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes [PDF]

, 2009
Elevations of the levels of N-acetyl-aspartyl-glutamate (NAAG) and N-acetyl-aspartate (NAA) are associated with myelin loss in the leucodystrophies Canavan's disease and Pelizaeus-Merzbacher-like disease. NAAG and NAA can activate and antagonize neuronal
Attwell, D., Koodziejczyk, Karolina, Kolodziejczyk, K., Wade, A., Kradttir, Ragnhildur, Wade, Anna, Karadottir, R., Hamilton, Nicola B.; id_orcid, Attwell, David, Hamilton, N. B.   +9 more
core   +1 more source

The Neuroprotective Effect of Cannabinoid Receptor Agonist (WIN55,212-2) in Paraoxon Induced Neurotoxicity in PC12 Cells and N-methyl-D-aspartate Receptor Interaction [PDF]

Cell Journal, 2010
Objective: Considering that cannabinoids protect neurons against neurodegeneration, inthis study, the neuroprotective effect of WIN55,212-2 in paraoxon induced neurotoxicity inPC12 cells and the role of the N-methyl-D-aspartate (NMDA) receptor were ...
Hedayat Sahraei, Farideh Bahrami, Soheil Sadri, Leila Golmanesh, Mansoureh Hashemi   +4 more
doaj  

Cellular prion protein and NMDA receptor modulation: protecting against excitotoxicity

Frontiers in Cell and Developmental Biology, 2014
Although it is well established that misfolding of the cellular prion protein (PrPC) into the beta-sheet-rich, aggregated scrapie conformation (PrPSc) causes a variety of transmissible spongiform encephalopathies (TSEs), the physiological roles of PrPC ...
Stefanie A.G. Black, Stefanie A.G. Black, Peter K. Stys, Peter K. Stys, Gerald W. Zamponi, Gerald W. Zamponi, Shigeki eTsutsui, Shigeki eTsutsui   +7 more
doaj   +1 more source

Differential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior [PDF]

, 2001
Stimuli paired with primary rewards can acquire emotional valence and the ability to elicit automatic, Pavlovian approach responses that have been shown to be mediated by the nucleus accumbens. The present experiment investigated the effects of infusions
Rudolf N. Cardinal, Di Ciano, Patricia, Patricia Di Ciano, Cowell, Rosemary A., Rosie A. Cowell, Barry J. Everitt, Cardinal, Rudolf N., Simon J. Little, Little, Simon J., Everitt, Barry J.   +9 more
core   +1 more source