Results 41 to 50 of about 114,424 (204)

Potentiation of glycine-gated NR1/NR3A NMDA receptors relieves Ca2+-dependent outward rectification

, 2010
Glycine has diverse functions within the mammalian central nervous system. It inhibits postsynaptic neurons via strychnine-sensitive glycine receptors (GlyRs) and enhances neuronal excitation through co-activation of N-methyl-D-aspartate (NMDA) receptors.
Betz, H., Christian Madry, Geiger, Jörg R. P., Bodo Laube, Betz, Heinrich, Jörg Geiger, Laube, B., Madry, Christian, Madry, C., Geiger, J., Laube, Bodo, Heinrich Betz   +11 more
core   +1 more source

NMDA-receptor activation but not ion flux is required for amyloid-beta induced synaptic depression. [PDF]

PLoS ONE, 2013
Alzheimer disease is characterized by a gradual decrease of synaptic function and, ultimately, by neuronal loss. There is considerable evidence supporting the involvement of oligomeric amyloid-beta (Aβ) in the etiology of Alzheimer's disease ...
Albert Tamburri, Anthony Dudilot, Sara Licea, Catherine Bourgeois, Jannic Boehm   +4 more
doaj   +1 more source

NMDA receptor inhibition increases, synchronizes, and stabilizes the collective pancreatic beta cell activity: Insights through multilayer network analysis.

PLoS Computational Biology, 2021
NMDA receptors promote repolarization in pancreatic beta cells and thereby reduce glucose-stimulated insulin secretion. Therefore, NMDA receptors are a potential therapeutic target for diabetes.
Marko Šterk, Lidija Križančić Bombek, Maša Skelin Klemen, Marjan Slak Rupnik, Marko Marhl, Andraž Stožer, Marko Gosak   +6 more
doaj   +1 more source

Anti-NMDA Receptor Encephalitis

, 2021
Anti N-methyl-D-aspartate receptor (NMDA)receptor encephalitis is one of the most common type of auto immune encephalitis. Its diagnosis is often delayed due to initial clinical presentation with psychiatric clinical features.
Hassan, Muhammad, Khattak, Neelma Naz, Waqar, Zaid, Rajput, Haris Majid, Athar, Iqra, Badshah, Mazhar   +5 more
core   +1 more source

Functional Proteins Involved in Regulation of Intracellular Ca2+ for Drug Development: Desensitization of N-Methyl-D-aspartate Receptor Channels

Journal of Pharmacological Sciences, 2005
N-Methyl-D-aspartate (NMDA) receptors are a principal subtype of excitatory ligand-gated ion channels with crucial roles in a variety of physiological and pathological processes in the mammalian central nervous system (CNS).
Noritaka Nakamichi, Yukio Yoneda
doaj   +1 more source

Comparative analyses of rodent and human brain in ageing and disease using novel NMDAR-2B selective probes [PDF]

, 2007
The NMDA subtype of excitatory ionotropic glutamate receptors is a hetero-oligomeric ligand-gated ion channel. Molecular cloning techniques have identified three types of NMDA receptor subunits, the NR 1, NR2A-D, and NR3A-B. NR2B-containing receptors are
Sheahan, Rebecca Louise
core  

Enhanced synaptic long-term potentiation in the anterior cingulate cortex of adult wild mice as compared with that in laboratory mice

Molecular Brain, 2009
Activation of N-methyl D-aspartate (NMDA) receptor is important for learning, memory and persistent pain. Genetic enhancement of NMDA receptor function by overexpressing NR2B subunit significantly enhances hippocampal long-term potentiation (LTP ...
Zhao Ming-Gao, Toyoda Hiroki, Wang Yu-Kun, Zhuo Min   +3 more
doaj   +1 more source

Activation of NMDA receptors in brain endothelial cells increases transcellular permeability

Fluids and Barriers of the CNS, 2022
Neurovascular coupling is a precise mechanism that induces increased blood flow to activated brain regions, thereby providing oxygen and glucose.
Kyu-Sung Kim, Min Tae Jeon, Eun Seon Kim, Chan Hee Lee, Do-Geun Kim   +4 more
doaj   +1 more source

Unconventional NMDA Receptor Signaling [PDF]

The Journal of Neuroscience, 2017
In the classical view, NMDA receptors (NMDARs) are stably expressed at the postsynaptic membrane, where they act via Ca2+to signal coincidence detection in Hebbian plasticity. More recently, it has been established that NMDAR-mediated transmission can be dynamically regulated by neural activity.
Kim Dore, Ivar S. Stein, Jennifer A. Brock, Pablo E. Castillo, Karen Zito, P. Jesper Sjöström   +5 more
openaire   +4 more sources

NMDA receptor in depression

, 2023
Depresija je jedan od najčešćih mentalnih poremećaja i predstavlja vodeći uzrok invaliditeta u svijetu. Karakteriziraju ju intenzivna tuga, gubitak interesa za uobičajene aktivnosti, osjećaj bespomoćnosti i bezvrijednosti, umanjen apetit, gubitak ...
Odobašić, Ena
core   +2 more sources