Results 131 to 140 of about 50,370,645 (240)

Influence of CO2 solubilization conditions on dissolution and precipitation in carbonate matrices

The Canadian Journal of Chemical Engineering, EarlyView.
CO2 solubilization temperature controls dissolution and precipitation in carbonate rocks at 60–100 bar. Factorial experiments show lower solubilization temperatures (~5°C) increase dissolution and porosity, while higher temperatures (~20°C) suppress dissolution—guiding subsurface reactive management.
Elivaldo Sapucaia da Silva Jr., Éliton Fontana, Luiz Fernando de Lima Luz Jr.   +2 more
wiley   +1 more source

Multi-objective optimization of light guide column injection molding process using RSM and NSGA‑II with numerical verification. [PDF]

PLoS One
Xu H.
europepmc   +1 more source

Protocol for Reconstituting Adaptor‐Mediated Activation of Full‐Length Kinesin‐1

Cytoskeleton, EarlyView.
ABSTRACT Kinesin‐1 is a member of the kinesin superfamily that plays an essential role in intracellular cargo transport. In the absence of cargo, Kinesin‐1 exhibits low motor activity due to autoinhibition. Multiple studies have demonstrated that adaptor proteins, which link cargos to Kinesin‐1, can activate Kinesin‐1 by releasing the autoinhibition ...
Haruka Masumoto, Kyoko Chiba
wiley   +1 more source

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source

Exposure‐Response Analyses of Datopotamab Deruxtecan (Dato‐DXd), a TROP2‐Directed Antibody‐Drug Conjugate, in Advanced Non‐small Cell Lung Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Exposure‐response analyses supported a favorable benefit‐risk profile of Dato‐DXd at 6 mg/kg Q3W in patients with advanced nonsquamous NSCLC. Datopotamab deruxtecan (Dato‐DXd) is a trophoblast cell‐surface antigen‐2 (TROP2)‐directed antibody‐drug conjugate (ADC) that has demonstrated clinical activity in patients with NSCLC who have received prior ...
Ying Hong, Anna M. Mc Laughlin, Yuzhuo Pan, Sofia Friberg Hietala, Sophie Peigné, Michael Chargualaf, Zoey Tang, Diansong Zhou, Naoyuki Tajima, Malaz Abutarif, Tushar Garimella   +10 more
wiley   +1 more source

Muscular Response in Sleep-Disordered Breathing Patients: New Methods of Assessment and Measurement. [PDF]

Clocks Sleep
Campisi R, Falco I, Iannella G, Maniaci A, Nava M, Bronzetti G, Bianchi D, Cescutti A, Casale M, Moffa A, Bianchini C, Pelucchi S, Bonzagni P, Pang KP, Pierri M, Vicini C.   +15 more
europepmc   +1 more source

CentoNewton, prototypes-présérie 08-100 & production 08-300 [PDF]

Suite aux améliorations découlant du projet de semestre de Grégory Affolter (montage souple sur embase + ajustement actif du span) ainsi que celles portées aux routines d'ajustement laser standard, on a réalisé d'abord des prototypes (testés avec succès ...
Maeder, Thomas
core   +1 more source

Patients with Chronic Inflammatory Diseases Can Experience Higher Exposure of Small Molecule Drugs than Healthy Volunteers: An Analysis of Recently Approved Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Chronic inflammation has long been known to downregulate the activity of certain cytochrome P450 (CYP) enzymes—the main enzymes responsible for the phase I metabolism of many small molecule drugs—potentially leading to higher exposures in patients with chronic inflammatory diseases compared to healthy volunteers. Neglecting this potential difference in
Johannes Tillil, Sathej Gopalakrishnan, Jennifer Dong, Karthik Venkatakrishnan, Charlotte Kloft, Wilhelm Huisinga, Lena Klopp‐Schulze   +6 more
wiley   +1 more source

Readmission Requires Survival and Access: Reframing Global Quality Metrics in Cirrhosis. [PDF]

Liver Int
Shen Y, Yuan J.
europepmc   +1 more source

England, Glaxo Laboratories -- 1959-64 -- OPV Production, International -- letter, 1959-01-08 - 1964-01-08?

, 1959
Letter from Dudgeon, Alastain to Sabin, Albert B.
Dudgeon, Alastain
core