Results 101 to 110 of about 77,307 (222)

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Survey on differential estimators for 3d point clouds

Computer Graphics Forum, EarlyView.
Abstract Recent advancements in 3D scanning technologies, including LiDAR and photogrammetry, have enabled the precise digital replication of real‐world objects. These methods are widely used in fields such as GIS, robotics, and cultural heritage. However, the point clouds generated by such scans are often noisy and unstructured, posing challenges for ...
Léo Arnal–Anger, Thibault Lejemble, David Coeurjolly, Loïc Barthe, Nicolas Mellado   +4 more
wiley   +1 more source

Enhanced pre-clinical assessment of total knee replacement using computational modelling with experimental corroboration & probabilistic applications

, 2009
Demand for Total Knee Replacement (TKR) surgery is high and rising; not just in numbers of procedures, but in the diversity of patient demographics and increase of expectations.
Strickland, Anthony Michael
core  

Evaluating Encodings for Bivariate Edges in Adjacency Matrices

Computer Graphics Forum, EarlyView.
Abstract We present the first empirical evaluation of techniques for encoding distributions of quantitative edge values within adjacency matrices. In many real‐world networks, edges represent not a single value but a set of measurements. While adjacency matrices preserve structural clarity, their compact cells limit the simultaneous display of multiple
J. Acosta‐Hernández, A. Lex, T. He
wiley   +1 more source

Modelling and solution methods for stochastic optimisation

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.In this thesis we consider two research problems, namely, (i) language constructs for modelling stochastic programming (SP) problems and (ii) solution ...
Zverovich, Victor
core  

Management Implications of Mesopelagic Forage Fisheries for Bigeye Tuna Stocks

Fisheries Management and Ecology, EarlyView.
ABSTRACT Many large marine predators forage on mesopelagic fish stocks, including commercially valuable tunas. The mesopelagic is under increasing interest for commercial exploitation, given its large biomass with potential to supply fishmeal for aquaculture feed or fish oil.
Ciara Willis, Di Jin, Melina Kourantidou, Simon R. Thorrold   +3 more
wiley   +1 more source

A Monomial Chaos Approach for Efficient Uncertainty Quantification in Computational Fluid Dynamics

, 2006
A monomial chaos approach is proposed for efficient uncertainty quantification in nonlinear computational problems. Propagating uncertainty through nonlinear equations can still be computationally intensive for existing uncertainty quantification methods.
Bijl, H., Witteveen, J.A.S. (author), Witteveen, J.A.S., Bijl, H. (author)   +3 more
core  

Exact and metaheuristic approaches to minimizing makespan in parallel machine scheduling with conflicting jobs

International Transactions in Operational Research, EarlyView.
Abstract We address the scheduling conflicting jobs on parallel identical machines problem with makespan minimization, a classical and computationally challenging variant of parallel machine scheduling. We develop and evaluate three distinct solution methodologies: a novel constraint programming (CP) formulation, and two metaheuristics: a multi ...
Roberto Maria Rosati, Dinh Quy Ta, Minh Hoàng Hà, Andrea Schaerf   +3 more
wiley   +1 more source

Constitution and function of intergenic genome regions in cultivated versus annual wild soybean in China

Journal of Integrative Plant Biology, EarlyView.
Three‐case restricted two‐stage multi‐locus multi‐allele genome‐wide association study identified main‐effect genes and detected the regulatory effects of intergenic loci on genes, enabling comprehensive dissection of the genic‐intergenic genetic system for quantitative traits and providing a strategy for studying their genetic basis.
Xiaoshuai Hao, Xinyang Hu, Yongpeng Pan, Qi Zhang, Ran Ou, Fenfen Jiang, Fangdong Liu, Jiaoping Zhang, Wubin Wang, Guangnan Xing, Junyi Gai, Jianbo He   +11 more
wiley   +1 more source

Preschool Duration, Family Background and Long‐Term Outcomes: Evidence From the Expansion of École Maternelle in France

Oxford Bulletin of Economics and Statistics, EarlyView.
ABSTRACT This paper analyses the long‐term effects of preschool education in France. We focus on the effect of preschool duration on educational attainment and labour market earnings in adulthood. Building on an old tradition of free and universal pre‐primary education, France implemented in the late 1960s a large‐scale expansion of preschooling ...
Francesco Andreoli, Arnaud Lefranc, Vincenzo Prete   +2 more
wiley   +1 more source