Results 151 to 160 of about 5,128,829 (242)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Epigenetic clocks of biological aging and cognitively healthy longevity: the Women's Health Initiative Memory Study. [PDF]

J Gerontol A Biol Sci Med Sci
LaCroix AZ, Zhang B, Nguyen S, Resnick SM, Ferrucci L, Horvath S, Lu AT, Espeland MA, Rapp SR, Beckman K, Nievergelt C, Maihofer AX, McEvoy LK, Shadyab AH.   +13 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Dosimetric Outcomes of Definitive Radiation Therapy to Anal Squamous Cell Carcinoma in a Single Institution Using Volumetric Modulated Arc Therapy Evaluated Against Australian and International Treatment Planning Guidelines. [PDF]

J Med Radiat Sci
Alshamrani F, Hsieh M, Karl A, Chamberlain L, Greenham S, Goodworth J, Wood M, Shakespeare T, Le T, Tahir AM.   +9 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Body Mass Index and Mortality Among Hospitalized Patients with a COPD-Coded Diagnosis in MIMIC-IV. [PDF]

Int J Chron Obstruct Pulmon Dis
Liu Z, Jing C, Ma X, Bi Z, Zhang W.
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Radioembolization for Colorectal Liver Metastases: Indications and Outcomes. [PDF]

J Gastrointest Cancer
Reddy S, Wu X, Rodwell N, Khan A, Navuluri R, Shaffer V, Fidelman N, Yu Q.   +7 more
europepmc   +1 more source