Computer-aided discovery of anti-HIV agents. [PDF]
Bioorg Med Chem, 2016 A review is provided on efforts in our laboratory over the last decade to discover anti-HIV agents. The work has focused on computer-aided design and synthesis of non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs) with collaborative efforts on biological assaying and protein crystallography.
Jorgensen WL.
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G-Quadruplex Forming Oligonucleotides as Anti-HIV Agents [PDF]
Molecules, 2015 Domenica Musumeci +2 more
exaly +2 more sources
Cyclotides as natural anti‐HIV agents [PDF]
Peptide Science, 2008 AbstractCyclotides are disulfide rich macrocyclic plant peptides that are defined by their unique topology in which a head‐to‐tail cyclized backbone is knotted by the interlocking arrangement of three disulfide bonds. This cyclic cystine knot motif gives the cyclotides exceptional resistance to thermal, chemical, or enzymatic degradation.
Ireland, David C. +4 more
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Electrochemistry of anti-HIV agents
Electrochemistry Communications, 2000 Square wave voltammetry has been used to study the electrochemical behaviour of anti-HIV drugs in aqueous solutions. The oxidation reaction of Carbovir (1) at a Pt microelectrode occurs at 1.12 V versus SCE and the peak current is proportional to the concentration. An electroanalytical technique for the determination of trace concentrations of Carbovir
S.C. Lemoult +3 more
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Clinical use of anti-HIV agents
Folia Pharmacologica Japonica, 2007 現在の抗HIV療法は，カクテル療法と言われるように3剤以上の多剤併用で行うことが基本である．国内で承認されている抗HIV薬は，その作用機序から，逆転写酵素阻害薬とプロテアーゼ阻害薬に分類され，逆転写酵素阻害薬は更に，核酸系と非核酸系とに分かれる．一般的には，非核酸系逆転写酵素阻害薬か，または，プロテアーゼ阻害薬をキードラッグとして，それに，2剤の核酸系逆転写酵素阻害薬を組み合わせて投与する．それぞれの薬剤の作用機序，特性，副作用を認識し，相互作用を考慮しつつ，組み合わせて投与することとなる．副作用は，同じ作用機序の薬剤に一般的に見られるものと，薬剤特異的なものがあり，注意が必要である．既に承認されている抗HIV薬の組み合わせのみではコントロール不良な多剤耐性HIVを持つ症例もあり ...
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Recent Progress in Synthesis, POM Analyses and SAR of Coumarin-Hybrids as Potential Anti-HIV Agents-A Mini Review. [PDF]
Pharmaceuticals (Basel), 2023 Suleiman M +8 more
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Discovery of an L-like Configuration for 3'-Fluoro-5'-norcarbonucleoside Phosphonates as Potent Anti-HIV Agents. [PDF]
ChemMedChem, 2022 Geant PY +4 more
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Non-clinical considerations for supporting accelerated inclusion of pregnant women in pre-licensure clinical trials with anti-HIV agents. [PDF]
J Int AIDS Soc, 2022 Greupink R +4 more
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Small Molecules of Natural Origin as Potential Anti-HIV Agents: A Computational Approach. [PDF]
Life (Basel), 2021 Crisan L, Bora A.
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Probing GFP Chromophore Analogs as Anti-HIV Agents Targeting LTR-III G-Quadruplex. [PDF]
Biomolecules, 2021 Ryazantsev DY +13 more
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