G-Quadruplex Forming Oligonucleotides as Anti-HIV Agents [PDF]
Molecules, 2015 Though a variety of different non-canonical nucleic acids conformations have been recognized, G-quadruplex structures are probably the structural motifs most commonly found within known oligonucleotide-based aptamers.
Domenica Musumeci +2 more
doaj +4 more sources
Recent Progress in Synthesis, POM Analyses and SAR of Coumarin-Hybrids as Potential Anti-HIV Agents—A Mini Review [PDF]
Pharmaceuticals, 2023 The human immunodeficiency virus (HIV) is the primary cause of acquired immune deficiency syndrome (AIDS), one of the deadliest pandemic diseases. Various mechanisms and procedures have been pursued to synthesise several anti-HIV agents, but due to the ...
Mustapha Suleiman +8 more
doaj +2 more sources
Computer-aided discovery of anti-HIV agents. [PDF]
Bioorg Med Chem, 2016 A review is provided on efforts in our laboratory over the last decade to discover anti-HIV agents. The work has focused on computer-aided design and synthesis of non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs) with collaborative efforts on biological assaying and protein crystallography.
Jorgensen WL.
europepmc +4 more sources
Potential Anti-HIV Agents from Marine Resources: An Overview
Marine Drugs, 2010 Human immunodeficiency virus (HIV) infection causes acquired immune deficiency syndrome (AIDS) and is a global public health issue. Anti-HIV therapy involving chemical drugs has improved the life quality of HIV/AIDS patients.
Thanh-Sang Vo, Se-Kwon Kim
doaj +3 more sources
Tuberculosis-associated IRIS in a young non-HIV patient undergoing TNF-α blockade for ankylosis spondylitis: a rare case report from Italy [PDF]
Journal of Clinical Tuberculosis and Other Mycobacterial DiseasesPatients receiving anti-TNF-α therapy are at increased risk of developing tuberculosis (TB). While immune reconstitution inflammatory syndrome (IRIS) is classically associated with HIV-infected individuals initiating antiretroviral therapy, it has also ...
Enrico Perugini +10 more
doaj +2 more sources
Natural Products as Anti-HIV Agents and Role in HIV-Associated Neurocognitive Disorders (HAND): A Brief Overview [PDF]
Frontiers in Microbiology, 2016 As the threat of Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) persists to rise, effective drug treatments are required to treat the infected people.
Kesava Rao Venkata Kurapati +4 more
doaj +2 more sources
Cyclotides as natural anti‐HIV agents [PDF]
Peptide Science, 2008 AbstractCyclotides are disulfide rich macrocyclic plant peptides that are defined by their unique topology in which a head‐to‐tail cyclized backbone is knotted by the interlocking arrangement of three disulfide bonds. This cyclic cystine knot motif gives the cyclotides exceptional resistance to thermal, chemical, or enzymatic degradation.
Ireland, David C. +4 more
openaire +5 more sources
Severe psoriatic arthritis in an HIV/AIDS patient treated with several TNF blockers switching: a case-based review [PDF]
Infectious Diseases and Tropical Medicine, 2022 OBJECTIVE: This case-based review aims to describe the clinical findings, treatment, and outcome of an HIV/AIDS patient with psoriatic arthritis (PsA) who received four anti-TNF agents and review case reports concerning this rare clinical association ...
J. Carvalho, C. Rodrigues
doaj +1 more source
Structure-Activity Relationships of Synthetic Coumarins as HIV-1 Inhibitors
Bioinorganic Chemistry and Applications, 2006 HIV/AIDS pandemics is a serious threat to health and development of mankind, and searching for effective anti-HIV agents remains actual. Considerable progress has been made in recent years in the field of drug development against HIV.
I. Kostova +3 more
doaj +2 more sources
A cocktail of thermally stable, chemically synthesized capture agents for the efficient detection of anti-gp41 antibodies from human sera. [PDF]
PLoS ONE, 2013 We report on a method to improve in vitro diagnostic assays that detect immune response, with specific application to HIV-1. The inherent polyclonal diversity of the humoral immune response was addressed by using sequential in situ click chemistry to ...
Jessica A Pfeilsticker +7 more
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