Results 11 to 20 of about 150,878 (257)

A cocktail of thermally stable, chemically synthesized capture agents for the efficient detection of anti-gp41 antibodies from human sera. [PDF]

PLoS ONE, 2013
We report on a method to improve in vitro diagnostic assays that detect immune response, with specific application to HIV-1. The inherent polyclonal diversity of the humoral immune response was addressed by using sequential in situ click chemistry to ...
Jessica A Pfeilsticker, Aiko Umeda, Blake Farrow, Connie L Hsueh, Kaycie M Deyle, Jocelyn T Kim, Bert T Lai, James R Heath   +7 more
doaj   +1 more source

The Anti-HIV Actions of 7- and 10-Substituted Camptothecins

Molecules, 2009
Camptothecin (CPT), a traditional anti-tumor drug, has been shown to possess anti-HIV-1 activity. To increase the antiviral potency, the anti-HIV activities of two CPT derivatives, 10-hydroxy-CPT and 7-hydroxymethyl-CPT, were evaluated in vitro.
Yu-Ye Li, Shi-Wu Chen, Liu-Meng Yang, Rui-Rui Wang, Wei Pang, Yong-Tang Zheng   +5 more
doaj   +1 more source

The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice.

PLoS ONE, 2020
The immune checkpoint programmed cell death protein 1 (PD-1) plays a major role in T cell exhaustion in cancer and chronic HIV infection. The inhibitor of apoptosis protein antagonist Debio 1143 (D1143) enhances tumor cell death and synergizes with anti ...
Michael Bobardt, Joseph Kuo, Udayan Chatterji, Norbert Wiedemann, Gregoire Vuagniaux, Philippe Gallay   +5 more
doaj   +1 more source

Oropharyngeal Candidosis in HIV-Infected Patients—An Update

Frontiers in Microbiology, 2018
Oropharyngeal candidosis (OPC) is an opportunistic fungal infection that is commonly found in HIV-infected patients, even in the twenty-first century. Candida albicans is the main pathogen, but other Candida species have been isolated.
Shankargouda Patil, Barnali Majumdar, Sachin C. Sarode, Gargi S. Sarode, Kamran H. Awan   +4 more
doaj   +1 more source

Antiviral and ROS scavenging potential of Carica papaya Linn and Psidium guajava leaves extract against HIV-1 infection

BMC Complementary Medicine and Therapies, 2023
Antiretroviral therapy is the only treatment option for HIV-infected patients; however, it has certain drawbacks in terms of developing multiple toxic side effects.
Pratiksha Jadaun, Prachibahen Shah, R. Harshithkumar, Madhukar S. Said, Shubhangi P. Bhoite, Sowmya Bokuri, Selvan Ravindran, Neetu Mishra, Anupam Mukherjee   +8 more
doaj   +1 more source

Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators

Molecules, 2022
The AIDS pandemic is still of importance. HIV-1 and HIV-2 are the causative agents of this pandemic, and in the absence of a viable vaccine, drugs are continually required to provide quality of life for infected patients.
Xujie Zhang, Lin Sun, Shujing Xu, Xiaoyu Shao, Ziyi Li, Dang Ding, Xiangyi Jiang, Shujie Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan   +13 more
doaj   +1 more source

Waking Up the Sleepers: HIV Latency and Reactivation

Journal of the Formosan Medical Association, 2008
In a patient infected with HIV-1, the presence of latently infected cells from which the virus can be reactivated and rekindle HIV infection in the patient necessitates lifelong administration of antiretroviral treatment.
Hoi Ping Mok, Andrew Lever
doaj   +1 more source

Small-Molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins

Biomolecules, 2021
The capsid of human immunodeficiency virus type 1 (HIV-1) is a shell that encloses viral RNA and is highly conserved among many strains of the virus. It forms a conical structure by assembling oligomers of capsid (CA) proteins. CA dysfunction is expected
Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Masayuki Fujino, Masaki Kurakami, Sayaka Boku, Miyuki Nakayama, Moemi Kaneko, Nami Ohashi, Osamu Kotani, Tsutomu Murakami, Hironori Sato, Hirokazu Tamamura   +12 more
doaj   +1 more source

Otolaryngologic manifestations in HIV disease: clinical aspects and treatment Manifestações otorrinolaringológicas na infecção pelo HIV: aspectos clínicos e terapêuticos

Brazilian Journal of Otorhinolaryngology, 2011
HIV is a pandemic infection with cases notified in almost all countries. The reported prevalence of symptoms in the head and neck is about 80%; otolaryngologists may be the first physician to see such patients.
Fernanda Alves Sanjar, Barbara Elvina Ulisses Parente Queiroz, Ivan Dieb Miziara   +2 more
doaj   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source