Results 11 to 20 of about 242,381 (303)

Safety of antiretrovirals in pregnacy [PDF]

Vojnosanitetski Pregled, 2011
nema
Dragović Gordana, Grbović Leposava, Jevtović Đorđe, Anđelić Spaso, Vasić Bojan, Lukić Relja   +5 more
doaj   +1 more source

The Anti-HIV Actions of 7- and 10-Substituted Camptothecins

Molecules, 2009
Camptothecin (CPT), a traditional anti-tumor drug, has been shown to possess anti-HIV-1 activity. To increase the antiviral potency, the anti-HIV activities of two CPT derivatives, 10-hydroxy-CPT and 7-hydroxymethyl-CPT, were evaluated in vitro.
Yu-Ye Li, Shi-Wu Chen, Liu-Meng Yang, Rui-Rui Wang, Wei Pang, Yong-Tang Zheng   +5 more
doaj   +1 more source

AtriplaR/anti-TB Combination in TB/HIV Patients. Drug in Focus. [PDF]

, 2011
Co-administration of anti-tuberculosis and antiretroviral therapy is often inevitable in high-burden countries where tuberculosis is the most common opportunistic infection associated with HIV/AIDS. Concurrent use of rifampicin and several antiretroviral
Semvua Hadija H, Kibiki, Gibson S, Hadija H Semvua, Gibson S Kibiki, Semvua, Hadija H, Kibiki Gibson S   +5 more
core   +1 more source

The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice.

PLoS ONE, 2020
The immune checkpoint programmed cell death protein 1 (PD-1) plays a major role in T cell exhaustion in cancer and chronic HIV infection. The inhibitor of apoptosis protein antagonist Debio 1143 (D1143) enhances tumor cell death and synergizes with anti ...
Michael Bobardt, Joseph Kuo, Udayan Chatterji, Norbert Wiedemann, Gregoire Vuagniaux, Philippe Gallay   +5 more
doaj   +1 more source

Anti-HIV therapy: pipeline approaches and future directions [PDF]

, 2011
Human immunodeficiency virus (HIV), with about 30 million deaths and double infections (in developing countries), is an open challenge today for global scientists.
Lavkush Dwivedi, Mansi Shrivastava
core   +2 more sources

Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants. [PDF]

, 2006
BACKGROUND: Heterosexual intercourse remains the major route of HIV-1 transmission worldwide, with almost 5 million new infections occurring each year.
Wallace, GS, Mesquita Pedro MM, Fletcher, PS, Fletcher Patricia S, Patricia S Fletcher, Wallace Gregory S, Mesquita, PM, Pedro MM Mesquita, Robin J Shattock, Shattock Robin J, Gregory S Wallace, Shattock, RJ   +11 more
core   +1 more source

Oropharyngeal Candidosis in HIV-Infected Patients—An Update

Frontiers in Microbiology, 2018
Oropharyngeal candidosis (OPC) is an opportunistic fungal infection that is commonly found in HIV-infected patients, even in the twenty-first century. Candida albicans is the main pathogen, but other Candida species have been isolated.
Shankargouda Patil, Barnali Majumdar, Sachin C. Sarode, Gargi S. Sarode, Kamran H. Awan   +4 more
doaj   +1 more source

Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators

Molecules, 2022
The AIDS pandemic is still of importance. HIV-1 and HIV-2 are the causative agents of this pandemic, and in the absence of a viable vaccine, drugs are continually required to provide quality of life for infected patients.
Xujie Zhang, Lin Sun, Shujing Xu, Xiaoyu Shao, Ziyi Li, Dang Ding, Xiangyi Jiang, Shujie Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan   +13 more
doaj   +1 more source

Antiviral and ROS scavenging potential of Carica papaya Linn and Psidium guajava leaves extract against HIV-1 infection

BMC Complementary Medicine and Therapies, 2023
Antiretroviral therapy is the only treatment option for HIV-infected patients; however, it has certain drawbacks in terms of developing multiple toxic side effects.
Pratiksha Jadaun, Prachibahen Shah, R. Harshithkumar, Madhukar S. Said, Shubhangi P. Bhoite, Sowmya Bokuri, Selvan Ravindran, Neetu Mishra, Anupam Mukherjee   +8 more
doaj   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source