Reverse transcriptase inhibitors diminish systemic proinflammatory responses to bacterial pathogens. [PDF]
mBioBacterial infections can induce exuberant immune responses that can damage host tissues. Previously, we demonstrated that systemic Escherichia coli infection in mice causes tissue damage in the liver. This liver necrosis is associated with the expression
Hullahalli K +5 more
europepmc +2 more sources
Approved HIV reverse transcriptase inhibitors in the past decade. [PDF]
Acta Pharm Sin B, 2022 HIV reverse transcriptase (RT) inhibitors are the important components of highly active antiretroviral therapies (HAARTs) for anti-HIV treatment and pre-exposure prophylaxis in clinical practice.
Li G, Wang Y, De Clercq E.
europepmc +2 more sources
Investigational reverse transcriptase inhibitors for the treatment of HIV [PDF]
Expert Opinion on Investigational Drugs, 2015 While considerable advances have been made in the development of antiretroviral agents, there is still work to be done. Reverse transcriptase inhibitors are important drugs for the treatment of HIV, and considerable research is currently ongoing to develop new agents and to modify currently existing agents.Herein, the authors discuss both ...
Theodore J Cory +2 more
exaly +3 more sources
HTLV-1 reverse transcriptase homology model provides structural basis for sensitivity to existing nucleoside/nucleotide reverse transcriptase inhibitors. [PDF]
Virol JThe human T-lymphotropic virus type 1 (HTLV-1) infects millions of people globally and is endemic to various resource-limited regions. Infections persist for life and are associated with increased susceptibility to opportunistic infections and severe ...
Tardiota N +4 more
europepmc +2 more sources
Proposal of pharmacophore model for HIV reverse transcriptase inhibitors: Combined mutational effect analysis, molecular dynamics, molecular docking and pharmacophore modeling study. [PDF]
Int J Immunopathol PharmacolObjectives: Antiretroviral therapy (ART) efficacy is jeopardized by the emergence of drug resistance mutations in HIV, compromising treatment effectiveness.
Annan A +7 more
europepmc +2 more sources
Cost-effectiveness of the third-agent class in treatment-naive human immunodeficiency virus-infected patients in Portugal. [PDF]
PLoS ONE, 2012 IntroductionCurrent Portuguese HIV treatment guidelines recommend initiating antiretroviral therapy with a regimen composed of two Nucleoside Reverse Transcriptase Inhibitors plus one Non-nucleoside Reverse Transcriptase Inhibitor (2NRTI+NNRTI) or two ...
Filipa Aragão +2 more
doaj +1 more source
Reverse Transcriptase Inhibitors as Microbicides
Current HIV Research, 2012 The CAPRISA 004 study in South Africa has accelerated the development of vaginal and rectal microbicides containing antiretrovirals that target specific enzymes in the reproduction cycle of HIV, especially reverse transcriptase inhibitors (RTI). In this review we discuss the potential relevance of HIV-1 RTIs as microbicides, focusing in the nucleotide ...
Lewi, P. +7 more
openaire +5 more sources
Capacity of rTth polymerase to detect RNA in the presence of various inhibitors. [PDF]
PLoS ONE, 2018 The full potential of the real-time reverse transcription polymerase chain reaction (RT-PCR) as a rapid and accurate diagnostic method is limited by DNA polymerase inhibitors as well as reverse transcriptase inhibitors which are ubiquitous in clinical ...
Dongyang Cai +4 more
doaj +1 more source
Bangabandhu Sheikh Mujib Medical University Journal, 2016 Retinol molecule was modified to predict the inhibitors of telomerase reverse transcriptase for the treatment of arsenical cancer through in silico study. Telomerase activity is expressed in the cancerous conditions which can be the target for anticancer
Kipchu Tshering, Mir Misbahuddin
doaj +1 more source
Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol. [PDF]
PLoS Pathogens, 2006 Nonnucleoside reverse transcriptase inhibitors (NNRTIs) target HIV-1 reverse transcriptase (RT) by binding to a pocket in RT that is close to, but distinct, from the DNA polymerase active site and prevent the synthesis of viral cDNA.
Anna Figueiredo +5 more
doaj +1 more source