Results 11 to 20 of about 451,745 (342)

Approved HIV reverse transcriptase inhibitors in the past decade [PDF]

Acta Pharmaceutica Sinica B, 2022
HIV reverse transcriptase (RT) inhibitors are the important components of highly active antiretroviral therapies (HAARTs) for anti-HIV treatment and pre-exposure prophylaxis in clinical practice.
Guangdi Li, Yali Wang, Erik De Clercq
doaj   +3 more sources

HIV nucleoside reverse transcriptase inhibitors.

European Journal of Medicinal Chemistry, 2022
More than 40 years into the pandemic, HIV remains a global burden and as of now, there is no cure in sight. Fortunately, highly active antiretroviral therapy (HAART) has been developed to manage and suppress HIV infection.
F. Amblard, Dharmeshkumar Patel, E. Michailidis, S. Coats, M. Kasthuri, N. Biteau, Zahira Tber, M. Ehteshami, R. Schinazi   +8 more
semanticscholar   +3 more sources

Reverse transcriptase inhibitors diminish systemic proinflammatory responses to bacterial pathogens [PDF]

mBio
Bacterial infections can induce exuberant immune responses that can damage host tissues. Previously, we demonstrated that systemic Escherichia coli infection in mice causes tissue damage in the liver. This liver necrosis is associated with the expression
Karthik Hullahalli, Katherine G. Dailey, Ryan Acbay, Masataka Suzuki, George I. Balazs, Matthew K. Waldor   +5 more
doaj   +2 more sources

Focus on Chirality of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors [PDF]

Molecules, 2016
Chiral HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are of great interest since one enantiomer is often more potent than the corresponding counterpart against the HIV-1 wild type (WT) and the HIV-1 drug resistant mutant strains.
Valeria Famiglini, Romano Silvestri
doaj   +4 more sources

In vitro and ex vivo inhibition of human telomerase by anti-HIV nucleoside reverse transcriptase inhibitors (NRTIs) but not by non-NRTIs.

PLoS ONE, 2012
Telomerase is a specialized reverse transcriptase responsible for the de novo synthesis of telomeric DNA repeats. In addition to its established reverse transcriptase and terminal transferase activities, recent reports have revealed unexpected cellular ...
Kyle R Hukezalie, Naresh R Thumati, Hélène C F Côté, Judy M Y Wong   +3 more
doaj   +2 more sources

Avoiding Drug Resistance in HIV Reverse Transcriptase.

Chemical Reviews, 2021
HIV reverse transcriptase (RT) is an enzyme that plays a major role in the replication cycle of HIV and has been a key target of anti-HIV drug development efforts.
Maria E. Cilento, K. Kirby, S. Sarafianos   +2 more
semanticscholar   +3 more sources

Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome

New England Journal of Medicine, 2018
ART for the Aicardi–Goutieres Syndrome The genetic encephalopathy Aicardi–Goutieres syndrome is thought to be due to misidentification of self-derived nucleic acids and the induction of a type I in...
Gillian I. Rice, C. Meyzer, N. Bouazza, M. Hully, N. Boddaert, Michaela Semeraro, Leo A H Zeef, Flore Rozenberg, V. Bondet, D. Duffy, A. Llibre, J. Baek, Mame N Sambe, Elodie Henry, V. Jolaine, C. Barnerias, Magalie Barth, Alexandre Bélot, C. Cances, F. Debray, D. Doummar, M. Frémond, Naoki Kitabayashi, A. Lepelley, V. Levrat, I. Melki, Pierre Meyer, Marie-Christine Nouguès, F. Renaldo, M. Rodero, D. Rodriguez, A. Roubertie, L. Seabra, C. Uggenti, H. Abdoul, J. Treluyer, I. Desguerre, Stéphane Blanche, Y. Crow   +38 more
semanticscholar   +3 more sources

HTLV-1 reverse transcriptase homology model provides structural basis for sensitivity to existing nucleoside/nucleotide reverse transcriptase inhibitors [PDF]

Virology Journal
The human T-lymphotropic virus type 1 (HTLV-1) infects millions of people globally and is endemic to various resource-limited regions. Infections persist for life and are associated with increased susceptibility to opportunistic infections and severe ...
Nicolas Tardiota, Noushin Jaberolansar, Julia A. Lackenby, Keith J. Chappell, Jake S. O’Donnell   +4 more
doaj   +2 more sources

Proposal of pharmacophore model for HIV reverse transcriptase inhibitors: Combined mutational effect analysis, molecular dynamics, molecular docking and pharmacophore modeling study [PDF]

International Journal of Immunopathology and Pharmacology
Objectives: Antiretroviral therapy (ART) efficacy is jeopardized by the emergence of drug resistance mutations in HIV, compromising treatment effectiveness.
Azzeddine Annan, Noureddine Raiss, Sanae Lemrabet, Nezha Elomari, El Harti Elmir, Abdelkarim Filali-Maltouf, Leila Medraoui, Hicham Oumzil   +7 more
doaj   +2 more sources

Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors.

Journal of Medicinal Chemistry, 2022
Currently, HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a major component of the highly active anti-retroviral therapy (HAART) regimen.
Zhao Wang, S. Cherukupalli, Minghui Xie, Wenbo Wang, Xiangyi Jiang, Ruifang Jia, C. Pannecouque, E. De Clercq, Dongwei Kang, P. Zhan, Xinyong Liu   +10 more
semanticscholar   +1 more source