Results 111 to 120 of about 50,121 (202)

Decoding neuronal vulnerability: Multidimensional analysis of D1R‐ and D2R‐ medium‐sized spiny neurons in Huntington's disease

Brain Pathology, EarlyView.
D1R and D2R MSNs show distinct responses to Huntington's pathology. G&T‐sequencing of pre‐symptomatic MSNs reveals global LINE‐1 downregulation. While D1R‐MSNs display early transcriptomic changes (OXPHOS/translation upregulation) and reduced mutant huntingtin aggregation, D2R‐MSNs exhibit higher nuclear mHTT accumulation and greater CAG somatic ...
Guendalina Bergonzoni, Miguel Pellegrini, Aurora Savino, Martina Lazioli, Sarah Geurs, Lorenzo Graziani, Denise Ferrarini, Solaleh Khoramian Tusi, Esaria Oliver, Jarne Geurts, Sara Vinciguerra, Michele Tebaldi, Takshashila Tripathi, Isabella Pesce, Valeria Poli, Alessandro Romanel, Rosario Moratalla, Thierry Voet, Jasmin Morandell, Remo Sanges, Vanessa C. Wheeler, Erik Dassi, Marta Biagioli   +22 more
wiley   +1 more source

Caracterização de união por solda de tôpo em barras CA-50 com eletrodos revestidos [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Mecânica.Há grande necessidade da execução de emendas por solda de topo na construção civil utilizando o processo a arco elétrico
Alonso, Marcelo de Barros
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Liquid Biopsy and Multi‐Cancer Early Detection Tests for Cancer Screening: A Scoping Review

Clinical Genetics, EarlyView.
There is a large body of evidence on liquid biopsy and multi‐cancer detection tests for cancer screening. Most studies addressed test performance outcomes, while fewer addressed clinical outcomes, implementation, and cost‐effectiveness. No studies evaluated cancer mortality.
Tessa Robinson, Marian Saab, Lily Thao Nguyen, Pooja Kochar, Olivia Meggetto, Jill Tinmouth, Meghan J. Walker   +6 more
wiley   +1 more source

Desenvolvimento de insertos de aços rápidos sinterizados AISI T15 para usinagem [PDF]

, 2000
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro TecnológicoDesenvolvimento de um inserto, ângulos e quebra-cavacos, de aço rápido sinterizado da classe T15, para usinagem.
Friedrich, Delmonte Nunes
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Coagulopathy as initial manifestation of concomitant celiac disease and cystic fibrosis: a case report

Journal of Medical Case Reports, 2011
Introduction Celiac disease and cystic fibrosis have many common manifestations, such as malabsorption, steatorrhea and growth failure, and were for many years recognized as one clinical entity.
Zdraveska Nikolina, Kostovski Aco
doaj   +1 more source

Efficient exact formulations for the flexible job shop scheduling with flexible maintenance

International Transactions in Operational Research, EarlyView.
Abstract In modern manufacturing systems, integrating preventive maintenance into production scheduling is essential to ensure operational efficiency and equipment reliability. This paper addresses the flexible job shop scheduling problem under machine unavailability constraints caused by non‐fixed maintenance tasks.
Tom Perroux, Taha Arbaoui, Leila Merghem Boulahia, Khaled Hadj‐Hamou, Jean‐Dominique Regazzoni   +4 more
wiley   +1 more source

Estudo microestrutural e de resistência a corrosão por picadas dum aço inoxidável duplex vazado

, 2003
Estágio realizado na Ferespe - Fundição de Ferro e Aço, LdaRelatório de estágio curricular da LEMM 2002 ...
Silva, Joana Sofia Cruz Leal da
core   +1 more source

Method of meal delivery influences estimates of postprandial metabolism and alkaline tide in a benthic fish

Journal of Fish Biology, EarlyView.
Abstract Intragastric gavage is widely used in studies of digestive physiology to deliver standardised meals, yet it remains unclear whether it elicits postprandial metabolic and acid–base responses comparable to voluntary feeding. Here, we tested whether the method of meal delivery affects the magnitude and timing of the postprandial rise in metabolic
Junlin Chen, Barrett W. Wolfe, Harriet R. Goodrich   +2 more
wiley   +1 more source

An Electronic Health Record “Nudge” to Reduce Antipsychotic Medication Prescribing for Primary Care Patients With Dementia: A Pragmatic RCT

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background We hypothesized that an electronic health record (EHR) alert grounded in behavioral science could reduce new antipsychotic medication prescriptions for older adults with dementia. Methods We conducted a pragmatic clinical trial at a large academic health system, randomizing providers to receive the alert (intervention) or not ...
Catherine A. Sarkisian, Chad Wes Villaflores, Anne M. Walling, Sitaram S. Vangala, Eric M. Cheng, Suzanne Bliven Shu, Ajaya Pillai, Grace Y. Cheng, Noah Goldstein, John Mafi   +9 more
wiley   +1 more source

Avaliação eletroquimica da resistencia a corrosão do aço ABNT 4140 nitretado por plasma [PDF]

, 1993
Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas.A corrosão de materiais metálicos representa um dos maiores problemas do mundo moderno.
Mittelstadt, Friedrich Georg
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