Results 351 to 360 of about 268,148 (374)

Intrahippocampal LPS injections reduce Aβ load in APP+PS1 transgenic mice

Neurobiology of Aging, 2001
Multiple lines of evidence indicate that inflammatory processes are involved in the pathogenesis of Alzheimer's disease. Lipopolysaccharide (LPS) is widely used to induce inflammation in experimental systems. Consequently we injected LPS or saline intrahippocampally in 11 and 16 months old APP+PS1 transgenic mice to induce brain inflammation, then used
G, DiCarlo, D, Wilcock, D, Henderson, M, Gordon, D, Morgan   +4 more
openaire   +2 more sources

Chemotactic-like receptors and Aβ peptide induced responses in Alzheimer's Disease

Neurobiology of Aging, 2000
Evidence suggests that beta-amyloid (Abeta) has chemokine-like properties and may act through formyl chemotactic receptors (FPR) to induce pathophysiologically important functional changes in Alzheimer's disease (AD) microglia. We have shown that Abeta 1-42, fibrillar Abeta 1-40, and Abeta 25-35 potentiate the release of interleukin-1beta (IL-1beta ...
D, Lorton, J, Schaller, A, Lala, E, De Nardin   +3 more
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Glial activation in Alzheimer's disease: the role of Aβ and its associated proteins

Neurobiology of Aging, 2001
A common feature of Alzheimer's disease (AD) pathology is the abundance of reactive astrocytes and activated microglia in close proximity to neuritic plaques containing amyloid-beta protein (Abeta). The relationship between glial activation and neurodegeneration remains unclear, although several cytokines and inflammatory mediators produced by ...
L, Meda, P, Baron, G, Scarlato
openaire   +2 more sources

Regulation of amyloid precursor protein processing by Aβ in human glioma cells

Neurobiology of Aging, 2000
Amyloid precursor protein (APP) is cleaved to neurotoxic/proinflammatory amyloid beta protein (Abeta) or to the neuroprotective secreted alpha-APPs. A balance in APP metabolism may influence the outcome between toxicity and protection to central nervous system (CNS) neurons in Alzheimer's disease. Treatment of U-373 MG astrocytoma cells with aggregated
C D, Carlson, D L, Czilli, B D, Gitter
openaire   +2 more sources

Vascular and parenchymal Aβ deposition in the aging dog: correlation with behavior

Neurobiology of Aging, 2000
The behavior of 25 dogs was indirectly assessed by a formal questionnaire (evaluation of Age-Related Cognitive and Affective Disorders-ARCAD), filled out by the owner. The density of diffuse and vascular deposits was evaluated using four anti-Abeta peptide antibodies, in four temporal areas.
, Colle M-A, , Hauw J-J, F, Crespeau, T, Uchihara, H, Akiyama, F, Checler, P, Pageat, C, Duykaerts   +7 more
openaire   +2 more sources

Phenolic anti-inflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology

Neurobiology of Aging, 2001
Both oxidative damage and inflammation have been implicated in age-related neurodegenerative diseases including Alzheimer's Disease (AD). The yellow curry spice, curcumin, has both antioxidant and anti-inflammatory activities which confer significant protection against neurotoxic and genotoxic agents.
S A, Frautschy, W, Hu, P, Kim, S A, Miller, T, Chu, M E, Harris-White, G M, Cole   +6 more
openaire   +2 more sources

A New Structural Model of Aβ₄₀ Fibrils

Journal of the American Chemical Society, 2011
The amyloid fibrils of beta-amyloid (Aβ) peptides play important roles in the pathology of Alzheimer's disease. Comprehensive solid-state NMR (SSNMR) structural studies on uniformly isotope-labeled Aβ assemblies have been hampered for a long time by sample heterogeneity and low spectral resolution.
BERTINI, IVANO, GONNELLI, LEONARDO, LUCHINAT, CLAUDIO, MAO, JIAFEI, NESI, ANTONELLA   +4 more
openaire   +3 more sources

Protective Effect of Edaravone Against Aβ25-35-Induced Mitochondrial Oxidative Damage in SH-SY5Y Cells

Cellular and Molecular Biology, 2017
Amyloid-β (Aβ)-induced oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). Recent studies show that Aβ accumulation may lead to mitochondrial oxidative damage. In the present study, we investigated the protective effect of edaravone on mitochondrial damage in SH-SY5Y cells treated with Aβ25-35.
G-L, Zhang, L, Zhang, Y-Y, Guo, Z-L, Ma, H-Y, Wang, T, Li, J, Liu, Y, Du, L, Yao, T-T, Li, J-M, Du   +10 more
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The relationship between the variations in Gγ and Aγ promotors and the Hereditary Persistence of Fetal Hemoglobin (HPFH)

Cellular and Molecular Biology, 2018
In the present study, sixty-two samples that have 1.5% and upper level of fetal hemoglobin (HbF), were examined to investigate the relationship between HbF level and non-deletional mutations in both Gγ (G gamma) globin (HBG2) and Aγ (A gamma) globin (HBG1) genes.
Muhsin, Aydin, Eyyup, Rencuzogullari, Ayse, Dalyan, Suleyman, Bayram, Ahmet, Genc   +4 more
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Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Science, 1996
K. Hsiao, P. Chapman, S. Nilsen, C. Eckman, Y. Harigaya, S. Younkin, Fusheng Yang, G. Cole   +7 more
semanticscholar   +1 more source