Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Harnessing peatland rewetting for effective biochar-based carbon dioxide removal. [PDF]
BiocharRhymes JM +4 more
europepmc +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Short segment coronal plane stability screws in retrograde nailing of proximal femoral shaft fractures: a technical trick and case series. [PDF]
OTA IntMoon TJ, Adelstein J, Napora JK.
europepmc +1 more source
Fiscal Policy as a Stabilization Instrument [PDF]
, 2014 This paper investigates the role of the fiscal authority in the case in which a negative shock hits the economic system. We analyze the several kinds of behavior that the fiscal authority can adopt during a crisis and show how the various approaches impact upon the effectiveness of fiscal policy. In general, there are two approaches: a) Adopt a neutral
openaire
Comparison of Design Strategies for Promotion of β‐Peptide 14‐Helix Stability in Water
, 2008 Esther Vaz +4 more
openalex +2 more sources
Stability Guarantees for Translational Thrust-Propelled Vehicles Dynamics Through NMPC Designs
, 2020 Ngoc Thinh Nguyen +2 more
openalex +2 more sources
Obstructions to 𝒵-Stability for Unital Simple C*-Algebras [PDF]
, 2000 Guihua Gong, Xinhui Jiang, Hongbing Su
openalex +1 more source
Genetic Variability, Correlation, Path Coefficient and Stability Analysis for Yield and its Attributing Traits in Summer Green Gram [Vigna radiata (L.) Wilczek] Accessions [PDF]
, 2020 V. K. Desai +3 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source