Results 101 to 110 of about 995,911 (334)
The journal of prevention of Alzheimer's disease, 2018 ObjectivesWe previously reported the therapeutic potential of Bifidobacterium breve A1 (B. breve A1) for preventing cognitive impairment in Alzheimer’s disease model mice, which suggested that supplementation of the probiotics could be an effective ...
Yodai Kobayashi +5 more
semanticscholar +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease—From Brain Starch to Bench and Bedside
Diagnostics, 2017 Alzheimer’s disease is the most common cause of dementia. Over the last three decades, research has advanced dramatically and provided a detailed understanding of the molecular events underlying the pathogenesis of Alzheimer’s disease.
Matthias Pawlowski +2 more
doaj +1 more source
MAGE-A1 in lung adenocarcinoma as a promising target of chimeric antigen receptor T cells
Journal of Hematology & Oncology, 2019 BackgroundCancer/testis antigens (CTAs) are a special type of tumor antigen and are believed to act as potential targets for cancer immunotherapy.MethodsIn this study, we first screened a rational CTA MAGE-A1 for lung adenocarcinoma (LUAD) and explored ...
Yuan Mao +15 more
semanticscholar +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
International Journal of Information Management Data InsightsThis study aims to extend the Stimulus-Organism-Responses (SOR) model by investigating the influence of AI-related stimulus, particularly ChatGPT adoption in entrepreneurship, on individuals’ cognitive organism (e.g., digital entrepreneurial identity ...
Cong Doanh Duong +5 more
doaj +1 more source
Cell Cycle, 2018 In the present study, a patient-derived orthotopic xenograft (PDOX) model of recurrent cisplatinum (CDDP)-resistant metastatic osteosarcoma was treated with Salmonella typhimurium A1-R (S.
K. Igarashi +22 more
semanticscholar +1 more source
, 2018 AIMS: Ring annuloplasty is the gold standard of surgical repair in degenerative mitral valve disease. However, prosthetic annuloplasty has some drawbacks and potential hazards.
Grimaldi F1 +10 more
core
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Un vasospasme fatal compliquant une hémorragie méningée grave
The Pan African Medical Journal, 2015 Il s'agit d'une patiente de 70 ans, diabétique sous insulinothérapie, admise aux urgences en troubles de conscience. Le scanner cérébral à son admission a montré une hémorragie méningée grade IV de WFNS grade 4 de Fisher avec inondation ventriculaire et ...
Soumaya Touzani, Mohammed Khatouf
doaj +1 more source