Results 271 to 280 of about 995,911 (334)

Metal-Free Photoinduced Hydrogen Atom Transfer for Direct Thiolation of Hydridic α‑C(sp³)-H of Ethers. [PDF]

ACS Omega
Karr A, Picazo E.
europepmc   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Filamentous multiscale characterization of the cultivation of Actinomadura namibiensis pellets for model-based prediction of labyrinthopeptin A1 biosynthesis. [PDF]

Microb Cell Fact
Liu Q, Kozanecka ZJ, Liu J, Dohnt K, Krull R, Böl M.   +5 more
europepmc   +1 more source

Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids. [PDF]

Mol Cancer
Sexton-Oates A, Mathian É, Candeli N, Lim Y, Voegele C, Di Genova A, Mangé L, Li Z, van Weert T, Kalson L, Delhomme TM, Hillen LM, Blázquez-Encinas R, Gonzalez-Perez A, Morrison ML, Lauricella E, Mangiante L, Bonheme L, Moonen L, Absenger G, Altmuller J, Degletagne C, Brustugun OT, Cahais V, Centonze G, Chabrier A, Cuenin C, Damiola F, de Montpréville VT, Deleuze JF, Dingemans AC, Fadel É, Gadot N, Ghantous A, Graziano P, Hofman P, Hofman V, Ibáñez-Costa A, Lacomme S, Lopez-Bigas N, Lund-Iversen M, Milione M, Muscarella LA, Pedraza-Arevalo S, Perrin C, Planchard G, Popper H, Roz L, Sparaneo A, Buikhuisen W, van den Berg J, Tesselaar M, Kim J, Speel EJM, Tabone-Eglinger S, Walter T, Wright GM, Castaño JP, Chalabreysse L, Chen L, Caux C, Volante M, Girard N, Vignaud JM, Conde E, Mansuet-Lupo A, Brcic L, Pelosi G, Papotti MG, Lantuejoul S, Derks J, Dayton T, Alcala N, Foll M, Fernandez-Cuesta L.   +74 more
europepmc   +1 more source

Pulmonary Histoplasmosis, Taiwan, 1997-2024. [PDF]

Emerg Infect Dis
Liang CW, Hsieh CY, Lin SY.
europepmc   +1 more source

The climate change dilemma of ski destinations: adaptation becomes maladaptation. [PDF]

Front Sports Act Living
Li C, Huang TT, Zheng JR.
europepmc   +1 more source

Lyophilizable Thermostable Nano-Aluminum Adjuvant and Combinations Induced Robust Antigen-Specific Humoral and Cellular Immunity in Mice. [PDF]

Adv Healthc Mater
Zhou J, Bian L, Zhao X, Cui L, Li D, Xu J, Shi M, Li G, Wang X, Zeng J, Xing L, Sun B, Jiang C, Chen Y, Zhang Y.   +14 more
europepmc   +1 more source

A distal anterior cerebral artery aneurysm arising from the middle of three A2 branches treated by stent-assisted coiling: a case report. [PDF]

Front Surg
Guo H, Zhang N, Wang Y, Wang B, Li Y, Yang X.   +5 more
europepmc   +1 more source