Results 1 to 10 of about 197,485 (282)

Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models [PDF]

eLife
Parkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which is difficult to treat effectively. This study explores the therapeutic potential of targeting the A13 region, a heterogeneous region
Linda H Kim, Adam Lognon, Sandeep Sharma, Michelle A Tran, Cecilia Badenhorst, Taylor Chomiak, Stephanie Tam, Claire McPherson, Todd E Stang, Shane EA Eaton, Zelma HT Kiss, Patrick J Whelan   +11 more
doaj   +2 more sources

Curcumin analog A13 alleviates oxidative stress by activating Nrf2/ARE pathway and ameliorates fibrosis in the myocardium of high-fat-diet and streptozotocin-induced diabetic rats

Diabetology and Metabolic Syndrome, 2020
Background Diabetes mellitus is an important risk factor for cardiomyopathy. Increasing oxidative stress may be one of the main factors of diabetic cardiomyopathy.
Yan-Rong Li, Guorong Chen
exaly   +2 more sources

Introduction of Interpolation and Extrapolation Model in Lanczos-type Algorithms A13/B6 and A13/B13 to Enhance their Stability [PDF]

Journal of Mathematical and Fundamental Sciences, 2018
A new method to treat the inherent instability of Lanczos-type algorithms is introduced. It enables us to capture the properties of the sequence of iterates generated by a Lanczos-type algorithm by interpolating on this sequence of points.
Maharani, Abdellah Salhi, Rifka Amelia Suharto   +2 more
doaj   +4 more sources

The intensification of anticancer activity of LFM-A13 by erythropoietin as a possible option for inhibition of breast cancer

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Recombinant human erythropoietin (Epo) is an effective and convenient treatment for cancer-related anaemia. In our study for the first time, we evaluated the effect of simultaneous use of Epo and Bruton’s tyrosine kinase (BTK) inhibitor LFM-A13 on the ...
Dariusz Rozkiewicz, Justyna M Hermanowicz, Anna Tankiewicz-Kwedlo   +2 more
exaly   +2 more sources

Optimization and induction effect evaluation of complex inducer of Aquilaria sinensis based on factorial design [PDF]

Scientific Reports
Agarwood is a kind of valuable traditional Chinese medicine. However, natural agarwood has a long formation cycle and is in short supply. Herein, the complex inducer of artificial agarwood was screened and optimised based on design of experiments (DoE ...
Qiuyue Ding, Baoyi Qin, Shimin Deng, Jie Chen, Ziwei Liu, Weiping Zhou, Xiaoying Chen, Weimin Zhang, Xin Zhou, Xiaoxia Gao   +9 more
doaj   +2 more sources

Curcumin and its analog alleviate diabetes-induced damages by regulating inflammation and oxidative stress in brain of diabetic rats

Diabetology & Metabolic Syndrome, 2021
Background Diabetic encephalopathy is a severe diabetes complication with cognitive dysfunction and neuropsychiatric disability. The mechanisms underlying diabetic encephalopathy is believed to be relevant with oxidative stress, vascular amylin ...
Chengfeng Miao, Hanbin Chen, Yulian Li, Ying Guo, Feifei Xu, Qi Chen, Yanyan Zhang, Mengjun Hu, Guorong Chen   +8 more
doaj   +1 more source

Design, synthesis, and biological evaluation of potent FAK-degrading PROTACs

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
FAK mediated tumour cell migration, invasion, survival, proliferation and regulation of tumour stem cells through its kinase-dependent enzymatic functions and kinase-independent scaffolding functions. At present, the development of FAK PROTACs has become
Qiaohua Qin, Ruifeng Wang, Qinglin Fu, Guoqi Zhang, Tianxiao Wu, Nian Liu, Ruicheng Lv, Wenbo Yin, Yin Sun, Yixiang Sun, Dongmei Zhao, Maosheng Cheng   +11 more
doaj   +1 more source

Comparative Adsorptive Removal of Phosphate and Nitrate from Wastewater Using Biochar-MgAl LDH Nanocomposites: Coexisting Anions Effect and Mechanistic Studies

Nanomaterials, 2020
In this study, date-palm biochar MgAl-augmented double-layered hydroxide (biochar−MgAl−LDH) nanocomposite was synthesized, characterized, and used for enhancing the removal of phosphate and nitrate pollutants from wastewater.
Omar Alagha, Mohammad Saood Manzar, Mukarram Zubair, Ismail Anil, Nuhu Dalhat Mu’azu, Aleem Qureshi   +5 more
doaj   +1 more source

Synthesis and Biological Evaluation of Novel Synthetic Indolone Derivatives as Anti-Tumor Agents Targeting p53-MDM2 and p53-MDMX

Molecules, 2022
A series of novel indolone derivatives were synthesized and evaluated for their binding affinities toward MDM2 and MDMX. Some compounds showed potent MDM2 and moderate MDMX activities.
Yali Wang, Bo Ji, Zhongshui Cheng, Lianghui Zhang, Yingying Cheng, Yingying Li, Jin Ren, Wenbo Liu, Yuanyuan Ma   +8 more
doaj   +1 more source

Histone-induced thrombotic thrombocytopenic purpura in adamts13−/− zebrafish depends on von Willebrand factor

Haematologica, 2020
Thrombotic thrombocytopenic purpura (TTP) is caused by severe deficiency of ADAMTS13 (A13), a plasma metalloprotease that cleaves endothelium-derived von Willebrand factor (VWF).
Liang Zheng, Mohammad S. Abdelgawwad, Di Zhang, Leimeng Xu, Shi Wei, Wenjing Cao, X. Long Zheng   +6 more
doaj   +1 more source