Results 1 to 10 of about 38,428 (302)
Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models [PDF]
eLifeParkinson’s disease (PD) is characterized by extensive motor and non-motor dysfunction, including gait disturbance, which is difficult to treat effectively. This study explores the therapeutic potential of targeting the A13 region, a heterogeneous region
Linda H Kim +11 more
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Molecular and functional characterization of Schistosoma japonicum annexin A13
Veterinary Research, 2023 Schistosomiasis is a neglected tropical disease that affects humans and animals in tropical and subtropical regions worldwide. Schistosome eggs are responsible for the pathogenesis and transmission of schistosomiasis, thus reducing egg production is ...
Haoran Zhong +11 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Recombinant human erythropoietin (Epo) is an effective and convenient treatment for cancer-related anaemia. In our study for the first time, we evaluated the effect of simultaneous use of Epo and Bruton’s tyrosine kinase (BTK) inhibitor LFM-A13 on the ...
Justyna Magdalena Hermanowicz +2 more
exaly +3 more sources
Optimization and induction effect evaluation of complex inducer of Aquilaria sinensis based on factorial design [PDF]
Scientific ReportsAgarwood is a kind of valuable traditional Chinese medicine. However, natural agarwood has a long formation cycle and is in short supply. Herein, the complex inducer of artificial agarwood was screened and optimised based on design of experiments (DoE ...
Qiuyue Ding +9 more
doaj +2 more sources
Journal of Mathematical and Fundamental Sciences, 2018 A new method to treat the inherent instability of Lanczos-type algorithms is introduced. It enables us to capture the properties of the sequence of iterates generated by a Lanczos-type algorithm by interpolating on this sequence of points.
Maharani +2 more
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Nanomaterials, 2020 In this study, date-palm biochar MgAl-augmented double-layered hydroxide (biochar−MgAl−LDH) nanocomposite was synthesized, characterized, and used for enhancing the removal of phosphate and nitrate pollutants from wastewater.
Omar Alagha +5 more
doaj +1 more source
Diabetology & Metabolic Syndrome, 2021 Background Diabetic encephalopathy is a severe diabetes complication with cognitive dysfunction and neuropsychiatric disability. The mechanisms underlying diabetic encephalopathy is believed to be relevant with oxidative stress, vascular amylin ...
Chengfeng Miao +8 more
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Design, synthesis, and biological evaluation of potent FAK-degrading PROTACs
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 FAK mediated tumour cell migration, invasion, survival, proliferation and regulation of tumour stem cells through its kinase-dependent enzymatic functions and kinase-independent scaffolding functions. At present, the development of FAK PROTACs has become
Qiaohua Qin +11 more
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Molecules, 2022 A series of novel indolone derivatives were synthesized and evaluated for their binding affinities toward MDM2 and MDMX. Some compounds showed potent MDM2 and moderate MDMX activities.
Yali Wang +8 more
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Haematologica, 2020 Thrombotic thrombocytopenic purpura (TTP) is caused by severe deficiency of ADAMTS13 (A13), a plasma metalloprotease that cleaves endothelium-derived von Willebrand factor (VWF).
Liang Zheng +6 more
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