Results 141 to 150 of about 41,373 (300)

Design, synthesis and activity evaluation of tetrahydroisoquinoline‐based programmed cell death ligand 1 inhibitors

open access: yesSmart Molecules, EarlyView.
Based on a 3D‐quantitative structure‐activity relationship pharmacophore model, structural optimization of Y6 yielded Y7f. Mechanistic studies revealed that Y7f acted as a programmed death receptor 1/programmed cell death ligand 1 (PD‐L1) interaction inhibitor by inducing PD‐L1 dimerization. Y7f restored T‐cell function.
Menglin Yu   +15 more
wiley   +1 more source

BayesianKAN: A reaction condition optimization framework integrating Kolmogorov‐Arnold network and Bayesian optimization

open access: yesSmart Molecules, EarlyView.
A novel BayesianKAN framework integrates Kolmogorov‐Arnold networks with Bayesian optimization to efficiently navigate complex factor spaces, accelerating the discovery of optimal reaction conditions for chemical synthesis. Abstract Efficient optimization of chemical reaction conditions is crucial for enhancing reaction yield and selectivity, yet ...
Juntao Wang   +5 more
wiley   +1 more source

The Pink Tax: Price Discrimination, Product Differentiation, and Gender‐Based Pricing in Consumer Packaged Goods

open access: yesSouthern Economic Journal, EarlyView.
ABSTRACT This paper examines the economic mechanisms underlying persistent price gaps between products marketed to women and men, which is often referred to as the “Pink Tax.” Using NielsenIQ scanner data on toothbrushes, we provide evidence of gendered price differentials and analyze two mechanisms central to the literature: gender‐based price ...
Rong Zhang, Yu Yvette Zhang
wiley   +1 more source

Stresses in Above‐Ground Storage Tanks Subjected to Flood‐Borne Debris Impact

open access: yesSafety Science and Technology, EarlyView.
This study investigates the stresses induced in above‐ground storage tanks by flood‐borne debris, specifically steel pipes and wood poles. Findings demonstrate that debris impacts across the examined velocity range generate stresses within safe limits, not exceeding the yield stress threshold.
Sabarethinam Kameshwar   +2 more
wiley   +1 more source

Implementing Sustainable Talent Management in a Mission‐Driven SME: The Roles of Organizational Signaling and Managerial Agency

open access: yesThunderbird International Business Review, EarlyView.
ABSTRACT In response to triple‐bottom‐line sustainability challenges facing the global business environment, organizations increasingly incorporate sustainability principles into their HRM practices, including talent management (TM). This becomes especially challenging for small and medium‐sized enterprises (SMEs).
Kousay Abid, Thomas Garavan
wiley   +1 more source

Credit‐Driven Adaptive Grouping for Refined Cooperative Multi‐Agent Reinforcement Learning

open access: yesCAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Policy heterogeneity is crucial for achieving sophisticated coordination in complex collaborative tasks, which has emerged as one of the key challenges in multi‐agent reinforcement learning (MARL) in recent years. Notably, the grouping paradigm has made remarkable progress in addressing policy heterogeneity.
Yirui Liu   +6 more
wiley   +1 more source

A13 & B13 Breathing Easier [PDF]

open access: yesQuality Management in Health Care, 1993
Stephen R. Russell, Betsy L. Ross
openaire   +1 more source

Werner Hensellek und Peter Schilling, Vorarbeiten zu einem Augustinus-Lexikon. A13 = De Vera religione. Werksindex

open access: yes, 1983
Verheijen Luc. Werner Hensellek und Peter Schilling, Vorarbeiten zu einem Augustinus-Lexikon. A13 = De Vera religione. Werksindex. In: L'antiquité classique, Tome 52, 1983. pp.
Verheijen, Luc
core  

Fault‐Tolerant Fuzzy Boundary Control for Nonlinear Distributed Parameter Systems Under Limited Measurements and Markovian Failures

open access: yesCAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT This paper proposes a boundary control method for nonlinear distributed parameter systems (DPSs) with limited boundary measurements (BMs), as typically encountered in networked cyber‐physical processes with spatially distributed dynamics such as thermal and biomedical diffusion systems.
Yanlin Li   +5 more
wiley   +1 more source

Unlocking citizen participation: Network characteristics, sense of power, and place attachment as key factors in regional settings

open access: yesAustralian Journal of Public Administration, EarlyView.
Abstract This article analyses key factors related to citizen participation in place governance processes. We study how network characteristics (ties and trust), sense of power (ability to influence outcomes), and affective characteristics such as bond with place (place attachment) relate to resource‐intensive and resource‐extensive citizen ...
Laura Ripoll González   +3 more
wiley   +1 more source

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