Results 11 to 20 of about 197,522 (210)

Synthesis and Biological Evaluation of Novel Synthetic Indolone Derivatives as Anti-Tumor Agents Targeting p53-MDM2 and p53-MDMX

open access: yesMolecules, 2022
A series of novel indolone derivatives were synthesized and evaluated for their binding affinities toward MDM2 and MDMX. Some compounds showed potent MDM2 and moderate MDMX activities.
Yali Wang   +8 more
doaj   +1 more source

Histone-induced thrombotic thrombocytopenic purpura in adamts13−/− zebrafish depends on von Willebrand factor

open access: yesHaematologica, 2020
Thrombotic thrombocytopenic purpura (TTP) is caused by severe deficiency of ADAMTS13 (A13), a plasma metalloprotease that cleaves endothelium-derived von Willebrand factor (VWF).
Liang Zheng   +6 more
doaj   +1 more source

Parasporin A13-2 of Bacillus thuringiensis Isolates from the Papaloapan Region (Mexico) Induce a Cytotoxic Effect by Late Apoptosis against Breast Cancer Cells

open access: yesToxins, 2021
The protein A13-2 was obtained from Bacillus thuringiensis strains isolated from the Papaloapan watershed region (Oaxaca, Mexico). The cytotoxic activity of parasporal inclusions was studied against breast cancer cell line (MCF-7) and normal cell (human ...
Diego Becker Borin   +9 more
doaj   +1 more source

Involvement of A13 dopaminergic neurons located in the zona incerta in nociceptive processing: a fiber photometry study

open access: yesMolecular Brain, 2020
The roles of serotonergic and noradrenergic signaling in nociceptive processing in the central nervous system are well known. However, dopaminergic signaling is also relevant to various physical functions, including nociception.
Shunpei Moriya   +6 more
doaj   +1 more source

Magnetic Mg-Fe/LDH Intercalated Activated Carbon Composites for Nitrate and Phosphate Removal from Wastewater: Insight into Behavior and Mechanisms

open access: yesNanomaterials, 2020
This experimental work focused on the synthesis, characterization, and testing of a unique, magnetically separable, and eco-friendly adsorbent composite material for the advanced treatment and efficient removal of nitrate and phosphate pollutants from ...
Omar Alagha   +5 more
doaj   +1 more source

Molecular and functional characterization of Schistosoma japonicum annexin A13

open access: yesVeterinary Research, 2023
Schistosomiasis is a neglected tropical disease that affects humans and animals in tropical and subtropical regions worldwide. Schistosome eggs are responsible for the pathogenesis and transmission of schistosomiasis, thus reducing egg production is ...
Haoran Zhong   +11 more
doaj   +1 more source

Enriched environment downregulates macrophage migration inhibitory factor and increases parvalbumin in the brain following experimental stroke

open access: yesNeurobiology of Disease, 2011
Housing rodents in an enriched environment (EE) following experimental stroke enhances neurological recovery. Understanding the underlying neural cues may provide the basis for improving stroke rehabilitation.
Ana R. Inácio   +2 more
doaj   +1 more source

Migration Flows through the Lens of Human Resource Ageing

open access: yesBusiness Systems Research, 2022
Background: Ageing and shrinking of the European population influence the shrinking of central places and the hinterland of cities in a spatial structure. Migration also influences the shrinking or growing of spatial units.
Drobne Samo, Bogataj Marija
doaj   +1 more source

Two-loop beta functions of the Sine-Gordon model [PDF]

open access: yes, 2000
We recalculate the two-loop beta functions in the two-dimensional Sine-Gordon model in a two-parameter expansion around the asymptotically free point. Our results agree with those of Amit et al., J. Phys.
Amit D J   +5 more
core   +2 more sources

Symmetries of the Hirota Difference Equation [PDF]

open access: yes, 2017
Continuous symmetries of the Hirota difference equation, commuting with shifts of independent variables, are derived by means of the dressing procedure. Action of these symmetries on the dependent variables of the equation is presented.
Pogrebkov, Andrei K.
core   +3 more sources

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