Results 171 to 180 of about 1,660,729 (286)

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Two-Step Ligand-Directed Covalent Fluorescent Labeling of the Adenosine A₁-Receptor That Maintains Its Orthosteric Binding Site's Availability to Bind Ligands. [PDF]

J Med Chem
Lin CY, Platt S, Goulding J, Briddon SJ, Kindon ND, Harwood CR, Lai CW, Kellam B, Hill SJ.   +8 more
europepmc   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

The Signaling Pathways Involved in the Anticonvulsive Effects of the Adenosine A₁ Receptor. [PDF]

Int J Mol Sci, 2020
Spanoghe J, Larsen LE, Craey E, Manzella S, Van Dycke A, Boon P, Raedt R.   +6 more
europepmc   +1 more source

Adenosine A1 receptor (ADORA1 ) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

β-Lapachone Exerts Hypnotic Effects via Adenosine A₁ Receptor in Mice. [PDF]

Biomol Ther (Seoul)
Lee DH, Jee HJ, Jung YS.
europepmc   +1 more source

The adenosine A1 receptor agonist WAG 994 suppresses acute kainic acid-induced status epilepticus in vivo. [PDF]

Neuropharmacology, 2020
Klaft ZJ, Duerrwald LM, Gerevich Z, Dulla CG.   +3 more
europepmc   +1 more source

Adenosine A₁ receptor is dispensable for hepatocyte glucose metabolism and insulin sensitivity. [PDF]

Biochem Pharmacol, 2021
Jain S, Barella LF, Wess J, Reitman ML, Jacobson KA.   +4 more
europepmc   +1 more source

Allosteric Modulators of the A1 Adenosine receptor

, 2011
The present invention provides compounds active as allosteric modulators of the A1 adenosine receptor and, thus, may be employed for the treatment of conditions mediated by the A1 adenosine receptor, such as treatment of pain, in particular chronic pain
ROMAGNOLI, Romeo, BARALDI, Pier Giovanni, A. R. Moorman   +2 more
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