Results 121 to 130 of about 1,226,263 (282)

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Thermally Induced Creep and Viscoelastic Behavior of Copper Micropillar Arrays

Advanced Science, EarlyView.
Copper micropillar arrays are fabricated by electrodeposition within through‐glass‐via, and their thermally induced time‐dependent deformation is quantified. Nanoindentation creep, EBSD, and TEM reveal a heat‐treatment‐driven transition between grain‐boundary‐mediated deformation and dislocation‐dominated creep, while Kelvin modeling captures ...
Miao Wang, Jihua Zhang, Libin Gao, Hongwei Chen, Wenbo Luo, Wenlei Li, Mingcheng Chen, Mengru Li, Dongbin Wang, Shuang Li, Ting Liu, Xingzhou Cai, Yong Li, Bin Peng, Wanli Zhang   +14 more
wiley   +1 more source

Modelling adrenal steroid profiles to inform monitoring guidance in congenital adrenal hyperplasiaResearch in context

EBioMedicine
Summary: Background: There is no consensus on how to monitor adrenal androgens in Congenital Adrenal Hyperplasia (CAH). Methods: Modelling of serum and salivary steroid profiles in healthy participants and patients with CAH randomised to either standard
Neil R. Lawrence, Jeremy Dawson, Zi-Qiang Lang, Alessandro Prete, Elizabeth S. Baranowski, Lina Schiffer, Angela E. Taylor, Aude Brac de la Perrière, Angelica Lindén Hirschberg, Anders Juul, Deborah P. Merke, John Newell-Price, D. Aled Rees, Nicole Reisch, Nike Stikkelbroeck, Philippe A. Touraine, Nils Krone, Brian Keevil, Gary S. Collins, Wiebke Arlt, Richard J.M. Ross   +20 more
doaj   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Quantum statistical manifolds: the linear growth case

, 2019
A class of vector states on a von Neumann algebra is constructed. These states belong to a deformed exponential family. One specific deformation is considered. It makes the exponential function asymptotically linear.
Naudts, Jan
core  

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

A4 [PDF]

Arthropod Management Tests, 2012
openaire   +1 more source

Carboxypeptidase A4

, 2013
Capitulo en: Rawlings, Neil D.; Salvesen, Guy (eds.). Handbook of Proteolytic Enzymes. 3rd ed. London: Academic Press, 2013, vol. 1, chapter 291, p.1307-1310. ISBN 978-0-12-382219-2.
Fricker, Lloyd D., Gomis-Rüth, F. Xavier   +1 more
openaire   +2 more sources

Models of Neutrino Masses and Mixings: a Progress Report

, 2007
We present some recent developments on model building for neutrino masses and mixings. In particular, we review tri-bimaximal neutrino mixing derived from discrete groups, notably A4. We discuss the problems encountered with extending the symmetry to the
Altarelli, Guido
core   +1 more source

Adhesion‐Related Macrophages Regulate Metabolic Homeostasis Through CAV‐1 Dependency

Advanced Science, EarlyView.
Adipose tissue harbors a distinct macrophage subpopulation, termed adhesion‐related macrophages (ARMs), which stably adhere to adipocytes. In obesity, ARMs represent the major expanding macrophage subset. They acquire material from adipocytes and rely on Caveolin‐1 for sustained lipid handling.
Wanyu Hu, Xiyan Liao, Limin Xie, Xiaoxiao Sun, Luodi Jing, Qin Zeng, Hongwei Jiang, Haowei Zhang, Lei Li, Fanqi Wang, Dandan Wang, Ying Mei, Yujin Din, Jianfeng Song, Wufuer Aini, Hui Zhou, Wanqin Xie, Helong Dai, Wei Liu, Joey Liu, Yan Cheng, Feng Liu, Willa A. Hsueh, Tuo Deng   +23 more
wiley   +1 more source