Effectiveness of the Fungal Metabolite 3-O-Methylfunicone towards Canine Coronavirus in a Canine Fibrosarcoma Cell Line (A72) [PDF]
Antibiotics, 2022 Canine coronavirus (CCoV), an alphacoronavirus, may cause self-limiting enteric disease in dogs, especially in puppies. The noteworthy plasticity of coronaviruses (CoVs) occurs through mutation and recombination processes, which sometimes generate new ...
Claudia Cerracchio +8 more
doaj +5 more sources
Potassium bicarbonate and D-ribose effects on A72 canine and HTB-126 human cancer cell line proliferation in vitro [PDF]
Cancer Cell International, 2011 Background The synergic action of KHCO3 and D-ribose is tested on A72 and HTB-126 cell lines proliferation using K:D-Rib solution. Altered Na+/K+ ATPase expression and activity were shown in patients with cancer.
Bussolati Simona +4 more
doaj +4 more sources
In Vitro Evaluation of Antiviral Activities of Funicone-like Compounds Vermistatin and Penisimplicissin against Canine Coronavirus Infection [PDF]
Antibiotics, 2023 Recent studies have demonstrated that 3-O-methylfunicone (OMF), a fungal secondary metabolite from Talaromyces pinophilus belonging to the class of funicone-like compounds, has antiviral activity against canine coronaviruses (CCoV), which causes ...
Claudia Cerracchio +8 more
doaj +2 more sources
Canine Coronavirus Activates Aryl Hydrocarbon Receptor during In Vitro Infection [PDF]
Viruses, 2022 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that interacts with substrates, including microbial metabolites.
Claudia Cerracchio +3 more
doaj +2 more sources
Harziachalasins A–G, polycyclic-fused cytochalasins from the endophytic fungus Trichoderma harzianum MLJ-4 with HIV latency reversal activity [PDF]
Natural Products and BioprospectingSeven new polycyclic-fused cytochalasins (CYTs), harziachalasins A–G (1–7), together with three known analogues (8–10) were isolated from the solid culture of the endophytic fungus Trichoderma harzianum MLJ-4, which was originally isolated from the ...
Yan-Jiang Zhang +10 more
doaj +2 more sources
In Vitro Evaluation of Aryl Hydrocarbon Receptor Involvement in Feline Coronavirus Infection [PDF]
VirusesFeline coronavirus (FCoV) is an alphacoronavirus (αCoV) that causes moderate or chronic asymptomatic infection in cats. However, in a single infected cat, FCoV can modify its cellular tropism by acquiring the ability to infect macrophages, resulting in ...
Luca Del Sorbo +15 more
doaj +2 more sources
Involvement of formyl peptide receptor 2 in canine coronavirus infection: in vitro and in Silico approaches [PDF]
Virology JournalCanine coronavirus type II (CCoV-II), an alphacoronavirus, is responsible for mild enteritis, especially in puppies, but due to its plasticity, it can also cause serious diseases in humans.
Rosa Giugliano +11 more
doaj +2 more sources
Bio-Protocol, 2017 The main obstacle to eradicating HIV-1 from patients is post-integration latency (Finzi et al., 1999). Antiretroviral treatments target only actively replicating virus, while latent infections that have low or no transcriptional activity remain untreated
Daniela Boehm, Melanie Ott
doaj +6 more sources
A72 INFLUENCE OF THE MICROBIOME ON DENDRITIC CELL FUNCTION [PDF]
J Can Assoc GastroenterolAbstract Background The intestinal microbiome educates the immune system, in part through signaling in antigen- presenting cells including dendritic cells (DCs). Germ-free mice exhibit DC deficiency, migration impairment, and priming dysfunction, implying a relationship between microbiota and DC ...
Miller, W L +4 more
europepmc +2 more sources
Molecular stability of a vaccine strain of Canine coronavirus after serial passages in A72 cells
Brazilian Journal of Veterinary Research and Animal Science, 2017 O Coronavírus canino (CCoV) ocorre como tipos I e II e infecta cães, levando principalmente a enterite, apesar do tipo II já ter sido associado à infecção generalizada e altamente letal. Uma vacina de CCoV-II inativada produzida em células caninas A72 é disponível mundialmente e largamente utilizada, apesar da sua estabilidade molecular após passagens ...
Barros, Iracema Nunes de +3 more
openaire +5 more sources