Results 1 to 10 of about 4,116,626 (248)

Mutations in viral nucleocapsid protein and endoRNase are discovered to associate with COVID19 hospitalization risk. [PDF]

Sci Rep, 2022
Abstract SARS-CoV-2 is spreading worldwide with continuously evolving variants, some of which occur in the Spike protein and appear to increase viral transmissibility. However, variants that cause severe COVID-19 or lead to other breakthroughs have not been well characterized.
Zhao LP, Roychoudhury P, Gilbert P, Schiffer J, Lybrand TP, Payne TH, Randhawa A, Thiebaud S, Mills M, Greninger A, Pyo CW, Wang R, Li R, Thomas A, Norris B, Nelson WC, Jerome KR, Geraghty DE.   +17 more
europepmc   +5 more sources

A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation. [PDF]

Nat Commun, 2021
Abstract Although human antibodies elicited by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein are profoundly boosted upon infection, little is known about the function of N-reactive antibodies. Herein, we isolate and profile a panel of 32 N protein-specific monoclonal antibodies (mAbs) from a
Kang S, Yang M, He S, Wang Y, Chen X, Chen YQ, Hong Z, Liu J, Jiang G, Chen Q, Zhou Z, Zhou Z, Huang Z, Huang X, He H, Zheng W, Liao HX, Xiao F, Shan H, Chen S.   +19 more
europepmc   +5 more sources

Author Correction: Mutations in viral nucleocapsid protein and endoRNase are discovered to associate with COVID19 hospitalization risk. [PDF]

Sci Rep, 2022
Zhao LP, Roychoudhury P, Gilbert P, Schiffer J, Lybrand TP, Payne TH, Randhawa A, Thiebaud S, Mills M, Greninger A, Pyo CW, Wang R, Li R, Thomas A, Norris B, Nelson WC, Jerome KR, Geraghty DE.   +17 more
europepmc   +1 more source

hnRNP K Degrades Viral Nucleocapsid Protein and Induces Type I IFN Production to Inhibit Porcine Epidemic Diarrhea Virus Replication. [PDF]

J Virol, 2022
Qin W, Kong N, Wang C, Dong S, Zhai H, Zhai X, Yang X, Ye C, Ye M, Tong W, Liu C, Yu L, Zheng H, Yu H, Lan D, Zhang W, Tong G, Shan T.   +17 more
europepmc   +1 more source

The viral nucleocapsid protein and the human RNA-binding protein Mex3A promote translation of the Andes orthohantavirus small mRNA. [PDF]

PLoS Pathog, 2021
Vera-Otarola J, Castillo-Vargas E, Angulo J, Barriga FM, Batlle E, Lopez-Lastra M.   +5 more
europepmc   +1 more source

Coronavirus genome packaging and nucleocapsid assembly

Journal of Virology
Coronaviruses are a family of positive-strand RNA viruses that exhibit highly selective packaging of their genomic RNA (gRNA) into assembled virions, despite the presence of a large excess of subgenomic viral RNA species and host RNA in infected cells ...
Paul S. Masters
doaj   +1 more source

TARDBP Inhibits Porcine Epidemic Diarrhea Virus Replication through Degrading Viral Nucleocapsid Protein and Activating Type I Interferon Signaling. [PDF]

J Virol, 2022
Dong S, Kong N, Zhang Y, Li Y, Sun D, Qin W, Zhai H, Zhai X, Yang X, Ye C, Ye M, Liu C, Yu L, Zheng H, Tong W, Yu H, Zhang W, Tong G, Shan T.   +18 more
europepmc   +1 more source

Combined immunization with SARS-CoV-2 spike and SARS-CoV nucleocapsid protects K18-hACE2 mice but increases lung pathology

npj Vaccines
Vaccines against SARS-CoV-2 have targeted the spike protein and have been successful at preventing disease. However, with the emergence of variants, spike-specific vaccines become less effective.
Jaekwan Kim, Alla Kachko, Prabhuanand Selvaraj, David Rotstein, Charles Brandon Stauft, Naveen Rajasagi, Yangqing Zhao, Tony Wang, Marian Major   +8 more
doaj   +1 more source

Direct relationship between protein expression and progeny yield of herpes simplex virus 1

mBio
Although viral protein expression and progeny virus production were independently shown to be highly heterogeneous in individual cells, their direct relationship, analyzed by considering their heterogeneities, has not been investigated to date.
Moeka Nobe, Yuhei Maruzuru, Kosuke Takeshima, Fumio Maeda, Hideo Kusano, Raiki Yoshimura, Takara Nishiyama, Hyeongki Park, Yoshitaka Kozaki, Shingo Iwami, Naoto Koyanagi, Akihisa Kato, Tohru Natsume, Shungo Adachi, Yasushi Kawaguchi   +14 more
doaj   +1 more source

Influences of cyclosporin A and non-immunosuppressive derivatives on cellular cyclophilins and viral nucleocapsid protein during human coronavirus 229E replication. [PDF]

Antiviral Res, 2020
Ma-Lauer Y, Zheng Y, Malešević M, von Brunn B, Fischer G, von Brunn A.   +5 more
europepmc   +1 more source