Results 1 to 10 of about 3,660,966 (235)
Simultaneous membrane and RNA binding by tick-borne encephalitis virus capsid protein.
PLoS Pathogens, 2023 Tick-borne encephalitis virus is an enveloped, pathogenic, RNA virus in the family Flaviviridae, genus Flavivirus. Viral particles are formed when the nucleocapsid, consisting of an RNA genome and multiple copies of the capsid protein, buds through the ...
Lauri Ilmari Aurelius Pulkkinen +8 more
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Development of an EBOV MiniG plus system as an advanced tool for anti-Ebola virus drug screening
Heliyon, 2023 The incidence of zoonotic diseases, such as coronavirus disease 2019 and Ebola virus disease, is increasing worldwide. However, drug and vaccine development for zoonotic diseases has been hampered because the experiments involving live viruses are ...
Chi-Ju Hsu +10 more
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Mutational analysis of Rift Valley fever phlebovirus nucleocapsid protein indicates novel conserved, functional amino acids. [PDF]
PLoS Neglected Tropical Diseases, 2017 Rift Valley fever phlebovirus (RVFV; Phenuiviridae, Phlebovirus) is an important mosquito-borne pathogen of both humans and ruminants. The RVFV genome is composed of tripartite, single stranded, negative or ambisense RNAs.
Timothy J Mottram +6 more
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Improved control of SARS-CoV-2 by treatment with a nucleocapsid-specific monoclonal antibody
The Journal of Clinical Investigation, 2022 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main antigen in all approved COVID-19 vaccines and is also the only target for monoclonal antibody (mAb) therapies.
Tanushree Dangi +10 more
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Journal of Immunology Research, 2021 The nucleocapsid protein (NP) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains immunogenic epitopes that can induce cytotoxic T lymphocyte (CTL) against viral infection. This makes the nucleocapsid protein a suitable candidate
Chaiyaporn Kuwentrai +7 more
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Applied Sciences, 2023 The COVID-19 pandemic has underscored the critical need for virus detection methods that are precise, simple, quick, and cost-effective. Electrochemical immunoassay-based methods are a practical solution given their ability to quickly, inexpensively ...
Christopher J. Lambert +7 more
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Diagnostics, 2023 Antibodies against the SARS-CoV-2 nucleocapsid protein are produced by the immune system in response to SARS-CoV-2 infection, but most available vaccines developed to fight the pandemic spread target the SARS-CoV-2 spike protein.
Verena Damiani +10 more
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PLoS ONE, 2022 Current SARS-CoV-2 serological assays generate discrepant results, and the longitudinal characteristics of antibodies targeting various antigens after asymptomatic to mild COVID-19 are yet to be established.
Sebastian Havervall +24 more
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In Silico Analysis of Mutated SARS-CoV-2 N Protein of Java Origin and Human IgG Antibody as a Potential Vaccine Candidate [PDF]
EPJ Web of ConferencesThe high mutation rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) may alter viral protein structures and reduce the effectiveness of vaccines that primarily target the spike (S) protein.
Maylina Mulyo Tjahyani Wenny +3 more
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Molecular Biomedicine, 2022 GSK3β has been proposed to have an essential role in Coronaviridae infections. Screening of a targeted library of GSK3β inhibitors against both SARS-CoV-2 and HCoV-229E to identify broad-spectrum anti-Coronaviridae inhibitors resulted in the ...
Tirosh Shapira +12 more
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