Results 1 to 10 of about 105,644 (246)

Antibody Response Profile in COVID-19 Infection in Healthcare Workers: Insights from a Study at a Reference Laboratory [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: The Coronavirus Disease 2019 (COVID-19) pandemic has imposed an unprecedented burden on our healthcare system. Serological testing for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) antibodies serves as useful marker for ...
Trupti Shetty, Anupa Dixit, Amar Dasgupta , Vineeth Nair, Heena Satam, Aditi Arora, Sanjay Arora   +6 more
doaj   +1 more source

Immunoinformatics Approach for Epitope Mapping of Immunogenic Regions (N, F and H Gene) of Small Ruminant Morbillivirus and Its Comparative Analysis with Standard Vaccinal Strains for Effective Vaccine Development

Vaccines, 2022
Background: Outbreaks of small ruminant morbillivirus (SRMV) are regularly occurring in Pakistan despite vaccine availability. This study was designed to identify substitutions within the immunogenic structural and functional regions of the nucleocapsid,
Muhammad Hasaan Aziz, Muhammad Zubair Shabbir, Muhammad Muddassir Ali, Zian Asif, Muhammad Usman Ijaz   +4 more
doaj   +1 more source

Enhancement of IL-6 Production Induced by SARS-CoV-2 Nucleocapsid Protein and Bangladeshi COVID-19 Patients’ Sera

Viruses, 2023
Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by severe acute respiratory syndrome coronavirus 2 that can have detrimental effects on multiple organs and accelerate patient mortality.
Abu Hasan, Rummana Rahim, Emi E. Nakayama, Kazuko Uno, Nazmul Hasan, Mizanur Rahman, Tatsuo Shioda   +6 more
doaj   +1 more source

Comparison of RT-qPCR results of different gene targets for SARS-CoV-2 in asymptomatic individuals during COVID-19 pandemic

The EuroBiotech Journal, 2021
A reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) is regarded as the most sensitive method available and is being used for screening procedure for all incoming passengers to Northern Cyprus for SARS-CoV-2.
Tuncel Gulten, Ergoren Mahmut Cerkez, Baddal Buket, Tulay Pinar, Arikan Ayse, Guler Emrah, Ozverel Cenk Serhan, Kaya Suer H., Sayan Murat, Sanlidag Tamer,   +10 more
doaj   +1 more source

Serological Testing for COVID-19, Immunological Surveillance, and Exploration of Protective Antibodies

Frontiers in Immunology, 2021
Serological testing is a powerful tool in epidemiological studies for understanding viral circulation and assessing the effectiveness of virus control measures, as is the case of SARS-CoV-2, the pathogenic agent of COVID-19.
Luis A. Peroni, Jessica M. Toscaro, Jessica M. Toscaro, Camila Canateli, Celisa C. C. Tonoli, Renata R. de Olivera, Celso E. Benedetti, Lais D. Coimbra, Alexandre Borin Pereira, Rafael E. Marques, José L. Proença-Modena, José L. Proença-Modena, Gabriel C. Lima, Gabriel C. Lima, Renata Viana, Jessica B. Borges, Hui Tzu Lin-Wang, Cely S. Abboud, Carlos Gun, Kleber G. Franchini, Kleber G. Franchini, Marcio C. Bajgelman, Marcio C. Bajgelman, Marcio C. Bajgelman   +23 more
doaj   +1 more source

A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin-Containing Protein (VCP/p97) as an Essential Host Factor for Flavivirus Uncoating

mBio, 2020
While the basic mechanisms of flavivirus entry and fusion are understood, little is known about the postfusion events that precede RNA replication, such as nucleocapsid disassembly. We describe here a sensitive, conditionally replication-defective yellow
Harish N. Ramanathan, Shuo Zhang, Florian Douam, Katrina B. Mar, Jinhong Chang, Priscilla L. Yang, John W. Schoggins, Alexander Ploss, Brett D. Lindenbach   +8 more
doaj   +1 more source

Recombinant COVID-19 vaccine based on recombinant RBD/Nucleoprotein and saponin adjuvant induces long-lasting neutralizing antibodies and cellular immunity

Frontiers in Immunology, 2022
SARS-CoV-2 has caused a global pandemic, infecting millions of people. An effective preventive vaccine against this virus is urgently needed. Here, we designed and developed a novel formulated recombinant receptor-binding domain (RBD) nucleocapsid (N ...
Amir Ghaemi, Parisa Roshani Asl, Hedieh Zargaran, Delaram Ahmadi, Asim Ali Hashimi, Elahe Abdolalipour, Sahar Bathaeian, Seyed Mohammad Miri   +7 more
doaj   +1 more source

Evolution of SARS-CoV-2 Envelope, Membrane, Nucleocapsid, and Spike Structural Proteins from the Beginning of the Pandemic to September 2020: A Global and Regional Approach by Epidemiological Week

Viruses, 2021
Monitoring acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genetic diversity and emerging mutations in this ongoing pandemic is crucial for understanding its evolution and assuring the performance of diagnostic tests, vaccines, and therapies ...
Paloma Troyano-Hernáez, Roberto Reinosa, África Holguín   +2 more
doaj   +1 more source

Virological Correlates of IgM–IgG Patterns of Response to SARS-CoV-2 Infection According to Targeted Antigens

Viruses, 2021
The virological meaning of the different patterns of serology in COVID-19 has been little examined in clinical settings. Asymptomatic subjects with IgM-spike (S) and IgG-nucleocapsid (N) determinations by chemiluminescence were studied for SARS-CoV-2 ...
Pablo Barreiro, Francisco Javier Candel, Juan Carlos Sanz, Jesús San Román, María del Mar Carretero, Marta Pérez-Abeledo, Belén Ramos, José Manuel Viñuela-Prieto, Jesús Canora, Francisco Javier Martínez-Peromingo, Antonio Zapatero   +10 more
doaj   +1 more source

Overview of the Nucleic-Acid Binding Properties of the HIV-1 Nucleocapsid Protein in Its Different Maturation States

Viruses, 2020
HIV-1 Gag polyprotein orchestrates the assembly of viral particles. Its C-terminus consists of the nucleocapsid (NC) domain that interacts with nucleic acids, and p1 and p6, two unstructured regions, p6 containing the motifs to bind ALIX, the cellular ...
Assia Mouhand, Marco Pasi, Marjorie Catala, Loussiné Zargarian, Anissa Belfetmi, Pierre Barraud, Olivier Mauffret, Carine Tisné   +7 more
doaj   +1 more source