Antibody Screening Results for Anti-Nucleocapsid Antibodies Towards the Development of a SARS-CoV-2 Nucleocapsid Protein Antigen Detecting Lateral Flow Assay [PDF]
, 2021 The global COVID-19 pandemic has created an urgent demand for large numbers of inexpensive, accurate, rapid, point-of-care diagnostic tests. Analyte-based assays are suitably inexpensive and can be rapidly mass-produced, but for sufficiently accurate ...
David, S. Boyle +18 more
core +2 more sources
Identification of (20R)-protopanaxadiol from Panax ginseng as a novel anti-SARS-CoV-2 compound. [PDF]
FEBS Open BioWe established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Takeda M +4 more
europepmc +2 more sources
Increased anti-nucleocapsid secretory IgA and consumption of complement component 3 in post-COVID syndrome patients. [PDF]
Front ImmunolAuthor contributions ZH: Conceptualization, Formal analysis, Funding acquisition, Investigation, Visualization, Writing – review & editing. WY: Conceptualization, Formal analysis, Funding acquisition, Investigation, Visualization, Writing – review ...
Hai Z +13 more
europepmc +2 more sources
SARS-CoV-2 Nucleocapsid Assembly Inhibitors: Repurposing Antiviral and Antimicrobial Drugs Targeting Nucleocapsid-RNA Interaction [PDF]
, 2020 SARS-CoV-2 pandemic has become a serious concern due to high transmission of this virus and unavailability of any definitive drugs yet in clinics. While novel antivirals are under investigation stage, scientists are also rigorously trying to use drug ...
UPASANA, RAY, Debica, Mukherjee
core +1 more source
Pathogens, 2021 The SARS-CoV-2 nucleocapsid protein (N) binds a single-stranded viral RNA genome to form a helical ribonucleoprotein complex that is packaged into virion particles. N is relatively conserved among coronaviruses and consists of the N-terminal domain (NTD)
Da Di +4 more
doaj +1 more source
Specific Recognition of a Stem-Loop RNA Structure by the Alphavirus Capsid Protein
Viruses, 2021 Alphaviruses are small enveloped viruses with positive-sense RNA genomes. During infection, the alphavirus capsid protein (Cp) selectively packages and assembles with the viral genomic RNA to form the nucleocapsid core, a process critical to the ...
Rebecca S. Brown +2 more
doaj +1 more source
Viruses, 2021 A growing number of studies indicate that mRNAs and long ncRNAs can affect protein populations by assembling dynamic ribonucleoprotein (RNP) granules.
Sébastien Lyonnais +17 more
doaj +1 more source
Viruses, 2022 The Human Immunodeficiency Virus-1 (HIV-1) nucleocapsid protein (NC) as a mature protein or as a domain of the Gag precursor plays important roles in the early and late phases of the infection. To better understand its roles, we searched for new cellular
Nedal Taha +7 more
doaj +1 more source
Functional analysis of the orthobunyavirus nucleocapsid (N) protein [PDF]
, 2008 Bunyamwera virus (BUNV) is the prototype of the family Bunyaviridae. It has a tripartite genome consisting of negative sense RNA segments called large (L), medium (M) and small (S). The S segment encodes the nucleocapsid protein (N) of 233 amino acids.
Eifan, Saleh A.
core +2 more sources
Time-Resolved Fluorescence Investigation of the Human Immunodeficiency Virus Type 1 Nucleocapsid Protein: Influence of the Binding of Nucleic Acids [PDF]
, 1999 Depending on the HIV-1 isolate, MN or BH10, the nucleocapsid protein, NCp7, corresponds to a 55- or 71-amino acid length product, respectively. The MN NCp7 contains a single Trp residue at position 37 in the distal zinc finger motif, and the BH10 NCp7 ...
Piemont, Etienne +13 more
core +1 more source