Results 11 to 20 of about 105,644 (246)

Recombinant SARS-CoV-2 Nucleocapsid Protein: Expression, Purification, and Its Biochemical Characterization and Utility in Serological Assay Development to Assess Immunological Responses to SARS-CoV-2 Infection

open access: yesPathogens, 2021
The SARS-CoV-2 nucleocapsid protein (N) binds a single-stranded viral RNA genome to form a helical ribonucleoprotein complex that is packaged into virion particles. N is relatively conserved among coronaviruses and consists of the N-terminal domain (NTD)
Da Di   +4 more
doaj   +1 more source

Specific Recognition of a Stem-Loop RNA Structure by the Alphavirus Capsid Protein

open access: yesViruses, 2021
Alphaviruses are small enveloped viruses with positive-sense RNA genomes. During infection, the alphavirus capsid protein (Cp) selectively packages and assembles with the viral genomic RNA to form the nucleocapsid core, a process critical to the ...
Rebecca S. Brown   +2 more
doaj   +1 more source

The HIV-1 Nucleocapsid Regulates Its Own Condensation by Phase-Separated Activity-Enhancing Sequestration of the Viral Protease during Maturation

open access: yesViruses, 2021
A growing number of studies indicate that mRNAs and long ncRNAs can affect protein populations by assembling dynamic ribonucleoprotein (RNP) granules.
Sébastien Lyonnais   +17 more
doaj   +1 more source

Hantavirus Nucleocapsid Protein Oligomerization [PDF]

open access: yesJournal of Virology, 2001
ABSTRACT Hantaviruses are enveloped, negative-strand RNA viruses which can be lethal to humans, causing either a hemorrhagic fever with renal syndrome or a hantaviral pulmonary syndrome. The viral genomes consist of three RNA segments: the L segment encodes the viral polymerase, the M segment encodes the viral surface glycoproteins G1 and G2,
A, Alfadhli   +5 more
openaire   +2 more sources

Helicoverpa armigera nucleopolyhedrovirus occlusion-derived virus-associated protein, HA100, affects oral infectivity in vivo but not virus replication in vitro [PDF]

open access: yes, 2011
ORF100 (ha100) of Helicoverpa armigera nucleopolyhedrovirus (HearNPV) has been reported as one of the unique genes of group II alphabaculoviruses encoding a protein located in the occlusion-derived virus (ODV) envelope and nucleocapsid.
Deng, F.   +7 more
core   +4 more sources

Upstream of N-Ras (Unr/CSDE1) Interacts with NCp7 and Gag, Modulating HIV-1 IRES-Mediated Translation Initiation

open access: yesViruses, 2022
The Human Immunodeficiency Virus-1 (HIV-1) nucleocapsid protein (NC) as a mature protein or as a domain of the Gag precursor plays important roles in the early and late phases of the infection. To better understand its roles, we searched for new cellular
Nedal Taha   +7 more
doaj   +1 more source

Nucleocapsid Assembly of Baculoviruses [PDF]

open access: yesViruses, 2019
The baculovirus nucleocapsid is formed through a rod-like capsid encapsulating a genomic DNA molecule of 80~180 kbp. The viral capsid is a large oligomer composed of many copies of various protein subunits. The assembly of viral capsids is a complex oligomerization process.
Shuling Zhao   +3 more
openaire   +3 more sources

Mechanisms of HIV-1 Nucleocapsid Protein Inhibition by Lysyl-Peptidyl-Anthraquinone Conjugates [PDF]

open access: yes, 2016
The Nucleocapsid protein NCp7 (NC) is a nucleic acid chaperone responsible for essential steps of the HIV-1 life cycle and an attractive candidate for drug development.
Alice Sosic   +12 more
core   +2 more sources

Serodominant SARS-CoV-2 Nucleocapsid Peptides Map to Unstructured Protein Regions

open access: yesMicrobiology Spectrum, 2023
The SARS-CoV-2 nucleocapsid (N) protein is highly immunogenic, and anti-N antibodies are commonly used as markers for prior infection. While several studies have examined or predicted the antigenic regions of N, these have lacked consensus and structural
Jacob P. Vandervaart   +10 more
doaj   +1 more source

Understanding Viral Transmission Behavior via Protein Intrinsic Disorder Prediction: Coronaviruses [PDF]

open access: yes, 2012
Besides being a common threat to farm animals and poultry, coronavirus (CoV) was responsible for the human severe acute respiratory syndrome (SARS) epidemic in 2002-4. However, many aspects of CoV behavior, including modes of its transmission, are yet to
Dunker, A. Keith   +2 more
core   +3 more sources

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