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The SARS-CoV-2 nucleocapsid protein (N) binds a single-stranded viral RNA genome to form a helical ribonucleoprotein complex that is packaged into virion particles. N is relatively conserved among coronaviruses and consists of the N-terminal domain (NTD)
Da Di +4 more
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Specific Recognition of a Stem-Loop RNA Structure by the Alphavirus Capsid Protein
Alphaviruses are small enveloped viruses with positive-sense RNA genomes. During infection, the alphavirus capsid protein (Cp) selectively packages and assembles with the viral genomic RNA to form the nucleocapsid core, a process critical to the ...
Rebecca S. Brown +2 more
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A growing number of studies indicate that mRNAs and long ncRNAs can affect protein populations by assembling dynamic ribonucleoprotein (RNP) granules.
Sébastien Lyonnais +17 more
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The Human Immunodeficiency Virus-1 (HIV-1) nucleocapsid protein (NC) as a mature protein or as a domain of the Gag precursor plays important roles in the early and late phases of the infection. To better understand its roles, we searched for new cellular
Nedal Taha +7 more
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Form-determining functions in Sindbis virus nucleocapsids: nucleosomelike organization of the nucleocapsid [PDF]
Purified intact Sindbis virus nucleocapsids were treated at different pH values or with various concentrations of divalent cations, cation chelators, salt, or formamide. The resulting structures were examined by velocity sedimentation, electron microscopy, and protein-protein cross-linking.
K M, Coombs, D T, Brown
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The Coronavirus Nucleocapsid Protein [PDF]
The nucleocapsid (N) proteins of coronaviruses, as with most enveloped viruses, have received less attention than the surface glycoproteins and generally have been perceived to be of lesser concern. Interest in this class of proteins, however, has been stimulated in recent years by such diverse developments as the recognition of the importance of RNA ...
Laude, Hubert, Masters, S.P.
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Serodominant SARS-CoV-2 Nucleocapsid Peptides Map to Unstructured Protein Regions
The SARS-CoV-2 nucleocapsid (N) protein is highly immunogenic, and anti-N antibodies are commonly used as markers for prior infection. While several studies have examined or predicted the antigenic regions of N, these have lacked consensus and structural
Jacob P. Vandervaart +10 more
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Baculovirus AC102 is a nucleocapsid protein that is crucial for nuclear actin polymerization and nucleocapsid morphogenesis [PDF]
ABSTRACT The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV), the type species of alphabaculoviruses, is an enveloped DNA virus that infects lepidopteran insects and is commonly known as a vector for protein expression and cell transduction.
Hepp, Susan E. +4 more
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The A, B, Cs of Herpesvirus Capsids
Assembly of herpesvirus nucleocapsids shares significant similarities with the assembly of tailed dsDNA bacteriophages; however, important differences exist.
Ritesh Tandon +2 more
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SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production
SARS-CoV-2 is highly pathogenic in humans and poses a great threat to public health worldwide. Clinical data shows a disturbed type I interferon (IFN) response during the virus infection.
Keli Chen +8 more
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