Results 21 to 30 of about 82,632 (214)

Serodominant SARS-CoV-2 Nucleocapsid Peptides Map to Unstructured Protein Regions

Microbiology Spectrum, 2023
The SARS-CoV-2 nucleocapsid (N) protein is highly immunogenic, and anti-N antibodies are commonly used as markers for prior infection. While several studies have examined or predicted the antigenic regions of N, these have lacked consensus and structural
Jacob P. Vandervaart, Nicole L. Inniss, Ted Ling-Hu, George Minasov, Grant Wiersum, Monica Rosas-Lemus, Ludmilla Shuvalova, Chad J. Achenbach, Judd F. Hultquist, Karla J. F. Satchell, Kelly E. R. Bachta   +10 more
doaj   +1 more source

Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization [PDF]

, 2013
All orthobunyaviruses possess three genome segments of single-stranded negative sense RNA that are encapsidated with the virus-encoded nucleocapsid (N) protein to form a ribonucleoprotein (RNP) complex, which is uncharacterized at high resolution.
Stonehouse, N. J., al., Et, Ranson, N. A., Hiscox, JA, Matthews, SV, Walter, C. T., Hiscox, J. A., Fooks, Anthony R., Walter, Cheryl T., Shepherd, DA, Ariza, Antonio, Shepherd, D. A., Elliott, R.M., Fooks, AR, Hiscox, Julian A., Dent, KC, Barr, John N., Edwards, T. A., Tanner, SJ, Dent, Kyle C., Matthews, S. V., Shepherd, D.A., Stonehouse, N.J., Barr, J. N., Dent, K.C., Barr, JN, Stonehouse, NJ, Hiscox, J.A., Tanner, S. J., Edwards, T.A., Stonehouse, Nicola J., Dent, K. C., Luo, Ming, Ashcroft, A.E., Shepherd, Dale A., Green, T. J., Ariza, A, Elliott, RM, Elliott, Richard M., Tanner, S.J., Tanner, Sian J., Ariza, A., Wu, W., Edwards, Thomas A., Matthews, Susan V., Ashcroft, Alison E., Wu, W, Green, Todd J., Green, TJ, Walter, C.T., Fooks, A. R., Fooks, A.R., Luo, M, Ashcroft, A. E., Ranson, Neil A., Luo, M., Walter, CT, Elliott, R. M., Green, T.J., Matthews, S.V., Ranson, N.A., Barr, J.N., Ashcroft, AE, Edwards, TA, Ranson, NA, Wu, Weining   +65 more
core   +1 more source

The A, B, Cs of Herpesvirus Capsids

Viruses, 2015
Assembly of herpesvirus nucleocapsids shares significant similarities with the assembly of tailed dsDNA bacteriophages; however, important differences exist.
Ritesh Tandon, Edward S. Mocarski, James F. Conway   +2 more
doaj   +1 more source

SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production

Viruses, 2020
SARS-CoV-2 is highly pathogenic in humans and poses a great threat to public health worldwide. Clinical data shows a disturbed type I interferon (IFN) response during the virus infection.
Keli Chen, Feng Xiao, Dingwen Hu, Weiwei Ge, Mingfu Tian, Wenbiao Wang, Pan Pan, Kailang Wu, Jianguo Wu   +8 more
doaj   +1 more source

Partial Functional Rescue of Helicoverpa armigera Single Nucleocapsid Nucleopolyhedrovirus Infectivity by Replacement of F Protein with GP64 from Autographa californica Multicapsid Nucleopolyhedrovirus [PDF]

, 2010
Two distinct envelope fusion proteins (EFPs) (GP64 and F) have been identified in members of the Baculoviridae family of viruses. F proteins are found in group II nucleopolyhedroviruses (NPVs) of alphabaculoviruses and in beta- and deltabaculoviruses ...
Feifei Yin, Shu Shen, Just M. Vlak, Fei Deng, Shen, S., Vlak, J.M., Deng, F., Manli Wang, Ying Tan, Yin, F.F., Hu, Z.H., Wang, M.L., Hualin Wang, Zhihong Hu, Tan, Y., Wang, H.L.   +15 more
core   +1 more source

Helicoverpa armigera nucleopolyhedrovirus occlusion-derived virus-associated protein, HA100, affects oral infectivity in vivo but not virus replication in vitro [PDF]

, 2011
ORF100 (ha100) of Helicoverpa armigera nucleopolyhedrovirus (HearNPV) has been reported as one of the unique genes of group II alphabaculoviruses encoding a protein located in the occlusion-derived virus (ODV) envelope and nucleocapsid.
Xushi Xu, Luo, S., Just M. Vlak, Fei Deng, Xu, X., Wang, H., Vlak, J.M., Deng, F., Zhang, Y., Yanfang Zhang, Marcel Westenberg, Sijiani Luo, Westenberg, M., Hu, Z., Hualin Wang, Zhihong Hu   +15 more
core   +1 more source

Evaluation of Diagnostic Performance of Three Indirect Enzyme-Linked Immunosorbent Assays for the Detection of IgG Antibodies to Ebola Virus in Human Sera

Viruses, 2019
Filovirus serological diagnosis and epidemiological investigations are hampered due to the unavailability of validated immunoassays. Diagnostic performance of three indirect enzyme-linked immunosorbent assays (I-ELISA) was evaluated for the detection of ...
Janusz T. Paweska, Naazneen Moolla, Nadia Storm, Veerle Msimang, Ousman Conteh, Jacqueline Weyer, Petrus Jansen van Vuren   +6 more
doaj   +1 more source

Potential Drug Candidates in Clinical Trials for the Treatment of Covid-19: An Updated Overview

Orbital: The Electronic Journal of Chemistry, 2021
The coronavirus (SARS-CoV-2) emerged in December 2019 in Wuhan, China and by the end of April 2020, it spread to more than 200 countries worldwide. Particularly the USA, Brazil, Spain, Italy, France, Germany, UK, Turkey, Iran, and Russia were the most ...
Osmar Ignacio Ayala Cáceres, Fernanda Timóteo, Kristiane Fanti Del Pino Santos, Rafael Rodrigo Piva Vasconcelos, Marco Antonio Utrera Martines, Juliana Jorge, Haroon ur Rashid   +6 more
doaj   +1 more source

Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism [PDF]

, 2013
Schmallenberg virus (SBV) is a newly emerged orthobunyavirus (family Bunyaviridae) that has caused severe disease in the offspring of farm animals across Europe.
Richard M. Elliott, Böttcher, Bettina, Li, P., Dong, H., Li, Ping, Dong, Changjiang, Dong, Haohao, Elliott, R., Boettcher, Bettina, Elliott, Richard M., Bottcher, B., Haohao Dong, Bettina Böttcher, Ping Li, Elliott, Richard M, Dong, C., Changjiang Dong   +16 more
core   +1 more source

Nucleocapsid- and Spike-specific IgG levels in saliva of newly positive, asymptomatic individuals versus prior positive, asymptomatic individuals.

, 2023
Saliva from NewPOS individuals infected with either CoV2US (n = 16) or CoV2Alpha (n = 15), as well as PCRNEG saliva from individuals who had been infected 2–37 weeks prior (PriorPOS, n = 402) with either CoV2US, CoV2Alpha, or a non-VOC, were used to ...
Jose A. Bazan (16859273), Abigail Norris Turner (7344479), Mikkel B. Quam (16859279), Jeff Jahnes (16859270), Alison Norris (2557534), Richard T. Robinson (12289326), Seth A. Faith (566702), Leona W. Ayers (9176825), Marisa Ruane-Foster (12289320), Najmus S. Mahfooz (16859267), Jacob Smith (1844773), Amanda Williams (102745), Marlena R. Merling (16859264), Michael Oglesbee (16859276)   +13 more
core   +1 more source