Alphavirus Nucleocapsid Packaging and Assembly [PDF]
Viruses, 2018 Alphavirus nucleocapsids are assembled in the cytoplasm of infected cells from 240 copies of the capsid protein and the approximately 11 kb positive strand genomic RNA. However, the challenge of how the capsid specifically selects its RNA package and assembles around it has remained an elusive one to solve.
Adriano Mendes, Richard J. Kuhn
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The A, B, Cs of Herpesvirus Capsids
Viruses, 2015 Assembly of herpesvirus nucleocapsids shares significant similarities with the assembly of tailed dsDNA bacteriophages; however, important differences exist.
Ritesh Tandon +2 more
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SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production
Viruses, 2020 SARS-CoV-2 is highly pathogenic in humans and poses a great threat to public health worldwide. Clinical data shows a disturbed type I interferon (IFN) response during the virus infection.
Keli Chen +8 more
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Non-Natural Linker Configuration in 2,6-Dipeptidyl-Anthraquinones Enhances the Inhibition of TAR RNA Binding/Annealing Activities by HIV-1 NC and Tat Proteins [PDF]
, 2018 The HIV-1 nucleocapsid (NC) protein represents an excellent molecular target for the development of antiretrovirals by virtue of its well-characterized chaperone activities, which play pivotal roles in essential steps of the viral life cycle. Our ongoing
Caliendo, Giuseppe +16 more
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Characterization of severe fever with thrombocytopenia syndrome in rural regions of Zhejiang, China. [PDF]
, 2014 Severe fever with thrombocytopenia syndrome virus (SFTSV) infections have recently been found in rural regions of Zhejiang. A severe fever with thrombocytopenia syndrome (SFTS) surveillance and sero-epidemiological investigation was conducted in the ...
feng, Cen +9 more
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Coronavirus Nucleocapsid Protein [PDF]
, 1998 The coronavirus nucleocapsid protein (N) is involved in encapsidation and packaging of viral RNA. In this study we investigated the ability of the bovine coronavirus (BCV) N protein to interact with RNA. Histidine-tagged BCV N (his-N) protein was expressed in bacteria.
R, Cologna, B G, Hogue
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The Coronavirus Nucleocapsid Protein [PDF]
, 1995 The nucleocapsid (N) proteins of coronaviruses, as with most enveloped viruses, have received less attention than the surface glycoproteins and generally have been perceived to be of lesser concern. Interest in this class of proteins, however, has been stimulated in recent years by such diverse developments as the recognition of the importance of RNA ...
Laude, Hubert, Masters, S.P.
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Form-determining functions in Sindbis virus nucleocapsids: nucleosomelike organization of the nucleocapsid [PDF]
Journal of Virology, 1989 Purified intact Sindbis virus nucleocapsids were treated at different pH values or with various concentrations of divalent cations, cation chelators, salt, or formamide. The resulting structures were examined by velocity sedimentation, electron microscopy, and protein-protein cross-linking.
K M, Coombs, D T, Brown
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Potential Drug Candidates in Clinical Trials for the Treatment of Covid-19: An Updated Overview
Orbital: The Electronic Journal of Chemistry, 2021 The coronavirus (SARS-CoV-2) emerged in December 2019 in Wuhan, China and by the end of April 2020, it spread to more than 200 countries worldwide. Particularly the USA, Brazil, Spain, Italy, France, Germany, UK, Turkey, Iran, and Russia were the most ...
Osmar Ignacio Ayala Cáceres +6 more
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The respiratory syncytial virus nucleoprotein–RNA complex forms a left-handed helical nucleocapsid [PDF]
, 2013 Respiratory Syncytial Virus (RSV) is an important human pathogen. Its nucleocapsid (NC), which comprises the negative sense RNA viral genome coated by the viral nucleoprotein N, is a critical assembly that serves as template for both mRNA synthesis and ...
Bhella +10 more
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