Results 31 to 40 of about 79,219 (253)

Nucleocapsid Structure of Negative Strand RNA Virus [PDF]

, 2020
Negative strand RNA viruses (NSVs) include many important human pathogens, such as influenza virus, Ebola virus, and rabies virus. One of the unique characteristics that NSVs share is the assembly of the nucleocapsid and its role in viral RNA synthesis ...
Ming Luo, James Ross Terrell, Shelby Ashlyn Mcmanus   +2 more
core   +1 more source

Helicoverpa armigera nucleopolyhedrovirus occlusion-derived virus-associated protein, HA100, affects oral infectivity in vivo but not virus replication in vitro [PDF]

, 2011
ORF100 (ha100) of Helicoverpa armigera nucleopolyhedrovirus (HearNPV) has been reported as one of the unique genes of group II alphabaculoviruses encoding a protein located in the occlusion-derived virus (ODV) envelope and nucleocapsid.
Xushi Xu, Luo, S., Just M. Vlak, Fei Deng, Xu, X., Wang, H., Vlak, J.M., Deng, F., Zhang, Y., Yanfang Zhang, Marcel Westenberg, Sijiani Luo, Westenberg, M., Hu, Z., Hualin Wang, Zhihong Hu   +15 more
core   +1 more source

Alphavirus Nucleocapsid Packaging and Assembly [PDF]

Viruses, 2018
Alphavirus nucleocapsids are assembled in the cytoplasm of infected cells from 240 copies of the capsid protein and the approximately 11 kb positive strand genomic RNA. However, the challenge of how the capsid specifically selects its RNA package and assembles around it has remained an elusive one to solve.
Adriano Mendes, Richard J. Kuhn
openaire   +3 more sources

Hantavirus Nucleocapsid Protein Oligomerization [PDF]

Journal of Virology, 2001
ABSTRACT Hantaviruses are enveloped, negative-strand RNA viruses which can be lethal to humans, causing either a hemorrhagic fever with renal syndrome or a hantaviral pulmonary syndrome. The viral genomes consist of three RNA segments: the L segment encodes the viral polymerase, the M segment encodes the viral surface glycoproteins G1 and G2,
A, Alfadhli, Z, Love, B, Arvidson, J, Seeds, J, Willey, E, Barklis   +5 more
openaire   +2 more sources

Assembly and transport of filovirus nucleocapsids

PLOS Pathogens, 2022
Filovirus-infected cells are characterized by typical cytoplasmic inclusion bodies (IBs) located in the perinuclear region. The formation of these IBs is induced mainly by the accumulation of the filoviral nucleoprotein NP, which recruits the other nucleocapsid proteins, the polymerase co-factor VP35, the polymerase L, the transcription factor VP30 and
Olga Dolnik, Stephan Becker
openaire   +3 more sources

Au(iii) compounds as HIV nucleocapsid protein (NCp7)–nucleic acid antagonists [PDF]

, 2017
The HIV nucleocapsid NCp7-SL2 RNA interaction is interrupted in the presence of a formally substitution-inert gold(dien)-nucleobase/N-heterocycle AuN4 compound where the N-heterocycle serves the dual purposes of a template for "non-covalent" molecular ...
Fabris, Daniele, Spell, Sarah R, Mangrum, John B, Peterson, Erica J, Ptak, Roger, Farrell, Nicholas P   +5 more
core   +1 more source

Drug Repurposing Commonly Against Dengue Virus Capsid and SARS-CoV-2 Nucleocapsid: An in Silico Approach [PDF]

, 2020
In the middle of SARS-CoV-2 pandemic, dengue virus (DENV) is giving a silent warning as the season approaches nearer. There is no specific antiviral against DENV for use in the clinics.
Rupesh, Roy, UPASANA, RAY, Debica, Mukherjee   +2 more
core   +1 more source

Improved control of SARS-CoV-2 by treatment with nucleocapsid-specific monoclonal antibody [PDF]

, 2022
The SARS-CoV-2 spike protein is the main antigen in all approved COVID-19 vaccines and is also the only target for monoclonal antibody therapies. Immune responses to other viral antigens are generated after SARS-CoV-2 infection, but their contribution to
Michelle Richner, Dangi, Tanushree, Pablo Penaloza-MacMaster, Igor J. Koralnik, Young Rock Chung, Visvabharathy, Lavanya, Richner, Michelle C., Bentley, Kirsten, Lavanya Visvabharathy, Richner, Justin M., Richner, Michelle, Penaloza-MacMaster, Pablo, Richard J. Stanton, Chung, Young Rock, Kirsten Bentley, Class, Jacob, Stanton, Richard J., Sarah Sanchez, Sanchez, Sarah, Koralnik, Igor J., Tanushree Dangi, Justin M. Richner, Jacob Class   +22 more
core   +1 more source

Potential Drug Candidates in Clinical Trials for the Treatment of Covid-19: An Updated Overview

Orbital: The Electronic Journal of Chemistry, 2021
The coronavirus (SARS-CoV-2) emerged in December 2019 in Wuhan, China and by the end of April 2020, it spread to more than 200 countries worldwide. Particularly the USA, Brazil, Spain, Italy, France, Germany, UK, Turkey, Iran, and Russia were the most ...
Osmar Ignacio Ayala Cáceres, Fernanda Timóteo, Kristiane Fanti Del Pino Santos, Rafael Rodrigo Piva Vasconcelos, Marco Antonio Utrera Martines, Juliana Jorge, Haroon ur Rashid   +6 more
doaj   +1 more source

Function of a retrotransposon nucleocapsid protein [PDF]

RNA Biology, 2010
Long terminal repeat (LTR) retrotransposons are not only the ancient predecessors of retroviruses, but they constitute significant fractions of the genomes of many eukaryotic species. Studies of their structure and function are motivated by opportunities to gain insight into common functions of retroviruses and retrotransposons, diverse mechanisms of ...
Sandmeyer, Suzanne B, Clemens, Kristina A   +1 more
openaire   +4 more sources