Results 11 to 20 of about 3,660,966 (235)

The Coronavirus Nucleocapsid Is a Multifunctional Protein [PDF]

Viruses, 2014
The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly ...
Ruth McBride, Marjorie van Zyl, Burtram C. Fielding   +2 more
doaj   +8 more sources

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

Acta Pharmaceutica Sinica B, 2020
The outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus continually lead to worldwide human infections and deaths. Currently, there is no specific viral protein-targeted therapeutics.
Sisi Kang, Mei Yang, Zhongsi Hong, Liping Zhang, Zhaoxia Huang, Xiaoxue Chen, Suhua He, Ziliang Zhou, Zhechong Zhou, Qiuyue Chen, Yan Yan, Changsheng Zhang, Hong Shan, Shoudeng Chen   +13 more
doaj   +3 more sources

Crimean-Congo hemorrhagic fever virus nucleocapsid protein has dual RNA binding modes. [PDF]

PLoS ONE, 2017
Crimean Congo hemorrhagic fever, a zoonotic viral disease, has high mortality rate in humans. There is currently no vaccine for Crimean Congo hemorrhagic fever virus (CCHFV) and chemical interventions are limited.
Subbiah Jeeva, Sean Pador, Brittany Voss, Safder Saieed Ganaie, Mohammad Ayoub Mir   +4 more
doaj   +2 more sources

Oligomerization of Uukuniemi virus nucleocapsid protein [PDF]

Virology Journal, 2010
Background Uukuniemi virus (UUKV) belongs to the Phlebovirus genus in the family Bunyaviridae. As a non-pathogenic virus for humans UUKV has served as a safe model bunyavirus in a number of studies addressing fundamental questions such as organization ...
Katz Anna, Freiberg Alexander N, Backström Vera, Schulz Axel R, Mateos Angelo, Holm Liisa, Pettersson Ralf F, Vaheri Antti, Flick Ramon, Plyusnin Alexander   +9 more
doaj   +4 more sources

Nucleocapsid protein as early diagnostic marker for SARS [PDF]

Emerging Infectious Diseases, 2004
Serum samples from 317 patients with severe acute respiratory syndrome (SARS) were tested for the nucleocapsid (N) protein of SARS-associated coronavirus, with sensitivities of 94% and 78% for the first 5 days and 6-10 days after onset, respectively. The
Yin, K, Feng, CS, Cheng, VCC, Biao Di, Kai Yin, Wang, Y, Di, B, Che, XY, Vincent C.C. Cheng, Hao, W, Chang-Sen Feng, Wan, ZY, Kwok-Yung Yuen, Yadi Wang, Xu, YC, Patrick C.Y. Woo, Zhuo-Yue Wan, Xiao-Yan Che, Yuen, KY, Yin-Chao Xu, Wei Hao   +20 more
core   +5 more sources

The nucleocapsid protein of human coronavirus NL63.

PLoS ONE, 2015
Human coronavirus (HCoV) NL63 was first described in 2004 and is associated with respiratory tract disease of varying severity. At the genetic and structural level, HCoV-NL63 is similar to other members of the Coronavirinae subfamily, especially human ...
Kaja Zuwała, Anna Golda, Wojciech Kabala, Michał Burmistrz, Michal Zdzalik, Paulina Nowak, Sylwia Kedracka-Krok, Mirosław Zarebski, Jerzy Dobrucki, Dominik Florek, Sławomir Zeglen, Jacek Wojarski, Jan Potempa, Grzegorz Dubin, Krzysztof Pyrc   +14 more
doaj   +4 more sources

SARS-CoV-2 nucleocapsid protein forms complexes with soluble complement regulatory proteins that can bind to the virion [PDF]

Scientific Reports
The SARS-CoV-2 nucleocapsid protein has been detected in the plasma of COVID-19 patients, and its levels in the plasma correlate with the severity of the disease. It is also an immunomodulatory protein, triggering the release of proinflammatory cytokines.
Jakub Víglaský, Katarína Bhide, Lea Talpasova, Ľubica Fialová, Mangesh Bhide   +4 more
doaj   +2 more sources

Nucleocapsid Assembly of Baculoviruses

Viruses, 2019
The baculovirus nucleocapsid is formed through a rod-like capsid encapsulating a genomic DNA molecule of 80~180 kbp. The viral capsid is a large oligomer composed of many copies of various protein subunits.
Shuling Zhao, Guanghui He, Yiheng Yang, Changyong Liang   +3 more
doaj   +2 more sources

Purification and Inhibitor Screening of the Full-Length SARS-CoV-2 Nucleocapsid Protein [PDF]

Molecules
Severe acute respiratory syndrome coronavirus 2 has undergone several mutations since 2020, and novel variants continue to emerge to this day. The immune escape ability of the emerging mutants is enhanced and results in robust transmissibility.
Chen Chen, Zhengfu Zhang, Qiao Zheng, Yingshun Zhou, Shujun Zhang   +4 more
doaj   +2 more sources

SARS-CoV-2 Nucleocapsid Protein Has DNA-Melting and Strand-Annealing Activities With Different Properties From SARS-CoV-2 Nsp13

Frontiers in Microbiology, 2022
Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world and has had a devastating impact on health and economy. The biochemical characterization of SARS-CoV-2 proteins is important for drug design
Bo Zhang, Yan Xie, Zhaoling Lan, Dayu Li, Junjie Tian, Qintao Zhang, Hongji Tian, Jiali Yang, Xinnan Zhou, Shuyi Qiu, Keyu Lu, Yang Liu, Yang Liu   +12 more
doaj   +1 more source