Results 21 to 30 of about 4,116,626 (248)

Proteins of Newcastle Disease Virus and of the Viral Nucleocapsid [PDF]

Journal of Virology, 1969
Newcastle disease virus was found to contain three major proteins. The structure unit of the viral nucleocapsid appears to be monomeric and to consist of a single large protein of an approximate molecular weight of 62,000.
I, Bikel, P H, Duesberg
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Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity. [PDF]

Cell Rep
Yang Z, Johnson BA, Meliopoulos VA, Ju X, Zhang P, Hughes MP, Wu J, Koreski KP, Clary JE, Chang TC, Wu G, Hixon J, Duffner J, Wong K, Lemieux R, Lokugamage KG, Alvarado RE, Crocquet-Valdes PA, Walker DH, Plante KS, Plante JA, Weaver SC, Kim HJ, Meyers R, Schultz-Cherry S, Ding Q, Menachery VD, Taylor JP.   +27 more
europepmc   +2 more sources

Interactions between coronavirus nucleocapsid protein and viral RNAs: implications for viral transcription [PDF]

Journal of Virology, 1988
The interaction of the mouse hepatitis virus (MHV) nucleocapsid protein (N) and viral RNA was examined. Monoclonal antibody specific for N protein coimmunoprecipitated MHV genomic RNA as well as all six MHV subgenomic mRNAs found in MHV-infected cells. In contrast, monoclonal antibodies to the MHV E2 or E1 envelope glycoproteins, an anti-I-A monoclonal
R S, Baric, G W, Nelson, J O, Fleming, R J, Deans, J G, Keck, N, Casteel, S A, Stohlman   +6 more
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Structural Insight Into the SARS-CoV-2 Nucleocapsid Protein C-Terminal Domain Reveals a Novel Recognition Mechanism for Viral Transcriptional Regulatory Sequences

Frontiers in Chemistry, 2021
Coronavirus disease 2019 (COVID-19) has caused massive disruptions to society and the economy, and the transcriptional regulatory mechanisms behind the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are poorly understood.
Mei Yang, Mei Yang, Suhua He, Xiaoxue Chen, Zhaoxia Huang, Ziliang Zhou, Zhechong Zhou, Qiuyue Chen, Shoudeng Chen, Shoudeng Chen, Sisi Kang, Sisi Kang   +11 more
doaj   +1 more source

Role of nucleocapsid protein of hantaviruses in intracellular traffic of viral glycoproteins [PDF]

Virus Research, 2013
To understand the role of nucleocapsid protein (NP) of hantaviruses in viral assembly, the effect of NP on intracellular traffic of viral glycoproteins Gn and Gc was investigated. Double staining of viral and host proteins in Hantaan virus (HTNV)-infected Vero E6 cells showed that Gn and Gc were localized to cis-Golgi, in which virus particles are ...
Shimizu, Kenta, Yoshimatsu, Kumiko, Koma, Takaaki, Yasuda, Shumpei P., Arikawa, Jiro   +4 more
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Nucleocapsid proteins: roles beyond viral RNA packaging [PDF]

WIREs RNA, 2016
Viral nucleocapsid proteins (NCs) enwrap the RNA genomes of viruses to form NC–RNA complexes, which act as a template and are essential for viral replication and transcription. Beyond packaging viral RNA, NCs also play important roles in virus replication, transcription, assembly, and budding by interacting with viral and host cellular proteins ...
Binbin, Ding, Yali, Qin, Mingzhou, Chen
openaire   +2 more sources

Simultaneous membrane and RNA binding by tick-borne encephalitis virus capsid protein.

PLoS Pathogens, 2023
Tick-borne encephalitis virus is an enveloped, pathogenic, RNA virus in the family Flaviviridae, genus Flavivirus. Viral particles are formed when the nucleocapsid, consisting of an RNA genome and multiple copies of the capsid protein, buds through the ...
Lauri Ilmari Aurelius Pulkkinen, Sarah Victoria Barrass, Marie Lindgren, Hudson Pace, Anna K Överby, Maria Anastasina, Marta Bally, Richard Lundmark, Sarah Jane Butcher   +8 more
doaj   +1 more source

Mutational analysis of Rift Valley fever phlebovirus nucleocapsid protein indicates novel conserved, functional amino acids. [PDF]

PLoS Neglected Tropical Diseases, 2017
Rift Valley fever phlebovirus (RVFV; Phenuiviridae, Phlebovirus) is an important mosquito-borne pathogen of both humans and ruminants. The RVFV genome is composed of tripartite, single stranded, negative or ambisense RNAs.
Timothy J Mottram, Ping Li, Isabelle Dietrich, Xiaohong Shi, Benjamin Brennan, Margus Varjak, Alain Kohl   +6 more
doaj   +1 more source

Nucleocapsid as a next-generation COVID-19 vaccine candidate

International Journal of Infectious Diseases, 2022
Multiple new variants of the SARS-CoV-2 virus have emerged globally, due to viral mutation. The majority of COVID-19 vaccines contain SARS-CoV-2 spike protein, which is susceptible to mutation. It is known that protection against COVID-19 after two doses
Bryan Oronsky, Christopher Larson, Scott Caroen, Farah Hedjran, Ana Sanchez, Elena Prokopenko, Tony Reid   +6 more
doaj   +1 more source

Sensitive and Specific Immunohistochemistry Protocol for Nucleocapsid Protein from All Common SARS-CoV-2 Virus Strains in Formalin-Fixed, Paraffin Embedded Tissues

Methods and Protocols, 2021
Human coronavirus disease 2019 (COVID-19) is a life-threatening and highly contagious disease caused by coronavirus SARS-CoV-2. Sensitive and specific detection of SARS-CoV-2 viral proteins in tissues and cells of COVID-19 patients will support ...
Yunguang Sun, Linna Ge, Sameer S. Udhane, John F. Langenheim, Mary J. Rau, Mollie D. Patton, Alexander J. Gallan, Juan C. Felix, Hallgeir Rui   +8 more
doaj   +1 more source