Results 11 to 20 of about 4,116,626 (248)

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

Acta Pharmaceutica Sinica B, 2020
The outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus continually lead to worldwide human infections and deaths. Currently, there is no specific viral protein-targeted therapeutics.
Sisi Kang, Mei Yang, Zhongsi Hong, Liping Zhang, Zhaoxia Huang, Xiaoxue Chen, Suhua He, Ziliang Zhou, Zhechong Zhou, Qiuyue Chen, Yan Yan, Changsheng Zhang, Hong Shan, Shoudeng Chen   +13 more
doaj   +4 more sources

Detection of Anti-Nucleocapsid Antibody in COVID-19 Patients in Bangladesh Is not Correlated with Previous Dengue Infection

Pathogens, 2021
Background: The assessment of antibody responses to severe acute respiratory syndrome coronavirus-2 is potentially confounded by exposures to flaviviruses. The aims of the present research were to determine whether anti-dengue antibodies affect the viral
Simon D. Lytton, Mahmuda Yeasmin, Asish Kumar Ghosh, Md. Rakibul Hassan Bulbul, Md. Maruf Ahmed Molla, Martha Herr, Helmut Duchmann, Md. Mohiuddin Sharif, Tasnim Nafisa, Md. Robed Amin, Nur Hosen, Md. Tanvir Rahman, Sumaiya Islam, Alimul Islam, Abul Khair Mohammad Shamsuzzaman   +14 more
doaj   +2 more sources

Crimean-Congo hemorrhagic fever virus nucleocapsid protein has dual RNA binding modes. [PDF]

PLoS ONE, 2017
Crimean Congo hemorrhagic fever, a zoonotic viral disease, has high mortality rate in humans. There is currently no vaccine for Crimean Congo hemorrhagic fever virus (CCHFV) and chemical interventions are limited.
Subbiah Jeeva, Sean Pador, Brittany Voss, Safder Saieed Ganaie, Mohammad Ayoub Mir   +4 more
doaj   +2 more sources

Nucleocapsid Assembly of Baculoviruses

Viruses, 2019
The baculovirus nucleocapsid is formed through a rod-like capsid encapsulating a genomic DNA molecule of 80~180 kbp. The viral capsid is a large oligomer composed of many copies of various protein subunits.
Shuling Zhao, Guanghui He, Yiheng Yang, Changyong Liang   +3 more
doaj   +2 more sources

Nucleocapsid Structure of Negative Strand RNA Virus

Viruses, 2020
Negative strand RNA viruses (NSVs) include many important human pathogens, such as influenza virus, Ebola virus, and rabies virus. One of the unique characteristics that NSVs share is the assembly of the nucleocapsid and its role in viral RNA synthesis ...
Ming Luo, James Ross Terrell, Shelby Ashlyn Mcmanus   +2 more
doaj   +2 more sources

SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA. [PDF]

PLoS Biology, 2021
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection causes Coronavirus Disease 2019 (COVID-19), a pandemic that seriously threatens global health.
Amanda Jack, Luke S Ferro, Michael J Trnka, Eddie Wehri, Amrut Nadgir, Xammy H Wrynla, Douglas Fox, Katelyn Costa, Sarah Stanley, Julia Schaletzky, Ahmet Yildiz   +10 more
doaj   +3 more sources

The Innate Antiviral Factors APOBEC3G and APOBEC3H Interact with the Nucleocapsids of Human Coronaviruses in an RNA-Dependent Manner [PDF]

Viruses
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) evolution has been marked by the rapid accumulation of mutations, among which cytosine-to-uracil (C-to-U) transitions represent a major proportion of observed genomic changes.
Jordi Exposito Trivino, Alexandra Decloux, Margaux Renier, Théo Massart, Justine Petit, Maxence Collard, Kévin Willemart, Aurélien Sellier, Rodrigue Tesse, Samuel Kindylides, Jean-Claude Twizere, Charles Nicaise, Lionel Tafforeau, Nicolas A. Gillet   +13 more
doaj   +2 more sources

Y-Box Binding Protein 1 Interacts with Dengue Virus Nucleocapsid and Mediates Viral Assembly [PDF]

mBio, 2022
Infection with dengue virus (DENV) induces vast rearrangements of the endoplasmic reticulum, which allows the compartmentalization of viral RNA replication and particle assembly. Both processes occur in concert with viral and cellular proteins.
Mayra Diosa-Toro, Debbie R. Kennedy, Vanessa Chuo, Vsevolod L. Popov, Julien Pompon, Mariano A. Garcia-Blanco   +5 more
doaj   +3 more sources

EGR1 Suppresses Porcine Epidemic Diarrhea Virus Replication by Regulating IRAV To Degrade Viral Nucleocapsid Protein. [PDF]

J Virol, 2021
Wang H, Kong N, Jiao Y, Dong S, Sun D, Chen X, Zheng H, Tong W, Yu H, Yu L, Zhang W, Tong G, Shan T.   +12 more
europepmc   +2 more sources

JNK kinase regulates phosphorylation of HCoV-229E nucleocapsid protein

npj Viruses
Identifying common host factors essential for the replication cycles of human coronaviruses (HCoV) could help uncover potential therapeutic targets. Mitogen-activated protein kinases (MAPKs) regulate critical cellular signaling pathways.
Yannick Brüggemann, Toni Luise Meister, Natalie Heinen, Emely Richter, Saskia Westhoven, Michael Poppe, Mohammed Samer Shaban, Leyla Sirkinti, Maximilian Nocke, Daniel Todt, Stephanie Pfaender, Michael Kracht, Eike Steinmann   +12 more
doaj   +2 more sources