Results 31 to 40 of about 4,116,626 (248)

Nucleocapsid-Independent Specific Viral RNA Packaging via Viral Envelope Protein and Viral RNA Signal [PDF]

Journal of Virology, 2003
ABSTRACT For any of the enveloped RNA viruses studied to date, recognition of a specific RNA packaging signal by the virus's nucleocapsid (N) protein is the first step described in the process of viral RNA packaging. In the murine coronavirus a selective interaction between the viral transmembrane envelope protein M and the viral
Narayanan, K, Chen, CJ, Maeda, J, Makino, S   +3 more
openaire   +2 more sources

Trimeric Hantavirus Nucleocapsid Protein Binds Specifically to the Viral RNA Panhandle [PDF]

Journal of Virology, 2004
ABSTRACT Hantaviruses are tripartite negative-sense RNA viruses and members of the Bunyaviridae family. The nucleocapsid (N) protein is encoded by the smallest of the three genome segments (S). N protein is the principal structural component of the viral capsid and is central to the hantavirus replication ...
M A, Mir, A T, Panganiban
openaire   +2 more sources

Functional analysis of the orthobunyavirus nucleocapsid (N) protein [PDF]

, 2008
Bunyamwera virus (BUNV) is the prototype of the family Bunyaviridae. It has a tripartite genome consisting of negative sense RNA segments called large (L), medium (M) and small (S). The S segment encodes the nucleocapsid protein (N) of 233 amino acids.
Eifan, Saleh A.
core   +2 more sources

Interaction of the Influenza A Virus Nucleocapsid Protein with the Viral RNA Polymerase Potentiates Unprimed Viral RNA Replication [PDF]

Journal of Virology, 2009
ABSTRACT The influenza A virus polymerase transcribes and replicates the eight virion RNA (vRNA) segments. Transcription is initiated with capped RNA primers excised from cellular pre-mRNAs by the intrinsic endonuclease of the viral polymerase.
Laura L, Newcomb, Rei-Lin, Kuo, Qiaozhen, Ye, Yunyun, Jiang, Yizhi Jane, Tao, Robert M, Krug   +5 more
openaire   +2 more sources

Identification of (20R)-protopanaxadiol from Panax ginseng as a novel anti-SARS-CoV-2 compound. [PDF]

FEBS Open Bio
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Takeda M, Maezono N, Uchikoshi R, Kato N, Ikeda M.   +4 more
europepmc   +2 more sources

Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication [PDF]

Science Signaling, 2022
Multiple coronaviruses have emerged independently in the past 20 years that cause lethal human diseases. Although vaccine development targeting these viruses has been accelerated substantially, there remain patients requiring treatment who cannot be vaccinated or who experience breakthrough infections.
Tomer M. Yaron, Brook E. Heaton, Tyler M. Levy, Jared L. Johnson, Tristan X. Jordan, Benjamin M. Cohen, Alexander Kerelsky, Ting-Yu Lin, Katarina M. Liberatore, Danielle K. Bulaon, Samantha J. Van Nest, Nikos Koundouros, Edward R. Kastenhuber, Marisa N. Mercadante, Kripa Shobana-Ganesh, Long He, Robert E. Schwartz, Shuibing Chen, Harel Weinstein, Olivier Elemento, Elena Piskounova, Benjamin E. Nilsson-Payant, Gina Lee, Joseph D. Trimarco, Kaitlyn N. Burke, Cait E. Hamele, Ryan R. Chaparian, Alfred T. Harding, Aleksandra Tata, Xinyu Zhu, Purushothama Rao Tata, Clare M. Smith, Anthony P. Possemato, Sasha L. Tkachev, Peter V. Hornbeck, Sean A. Beausoleil, Shankara K. Anand, François Aguet, Gad Getz, Andrew D. Davidson, Kate Heesom, Maia Kavanagh-Williamson, David A. Matthews, Benjamin R. tenOever, Lewis C. Cantley, John Blenis, Nicholas S. Heaton   +46 more
openaire   +3 more sources

Helicoverpa armigera nucleopolyhedrovirus occlusion-derived virus-associated protein, HA100, affects oral infectivity in vivo but not virus replication in vitro [PDF]

, 2011
ORF100 (ha100) of Helicoverpa armigera nucleopolyhedrovirus (HearNPV) has been reported as one of the unique genes of group II alphabaculoviruses encoding a protein located in the occlusion-derived virus (ODV) envelope and nucleocapsid.
Xushi Xu, Luo, S., Just M. Vlak, Fei Deng, Xu, X., Wang, H., Vlak, J.M., Deng, F., Zhang, Y., Yanfang Zhang, Marcel Westenberg, Sijiani Luo, Westenberg, M., Hu, Z., Hualin Wang, Zhihong Hu   +15 more
core   +1 more source

SARS-CoV-2 genomes from Saudi Arabia implicate nucleocapsid mutations in host response and increased viral load [PDF]

, 2021
Monitoring SARS-CoV-2 spread and evolution through genome sequencing is essential in handling the COVID-19 pandemic. Here, we sequenced 892 SARS-CoV-2 genomes collected from patients in Saudi Arabia from March to August 2020. We show that two consecutive
Mahmoud, Ahmed, Alsomali, Afrah, Almontashiri, Naif, Ooi, Amanda, Zhang, Huoming, Al-Omari, Awad, Hala, Sharif, Volz, Eric, Hashem, Anwar M, Mfarrej, Sara, Salunke, Rahul Pandurang, Perumal, Sadhasivam, Salih, Samer, Hashem, Anwar M., Alahmadi, Abdulaziz, Nugmanova, Raushan, Rajan, Issaac, Alofi, Fadwa, Mourier, Tobias, Naeem, Raeece, Salunke, Rahul P, Khogeer, Asim, Pain, Arnab, Rached, Fathia Ben, Douvropoulou, Olga, Moraga, Paula, Salunke, Rahul P., Al Mutair, Abbas, Dageeg, Abdullah, Guan, Qingtian, Esau, Luke, Shuaib, Muhammad, Shamsan, Abbas, Ooi, Amanda Siok Lee, Ben Rached, Fathia, Taha, Jumana, Khotani, Nashwa, Jorgensen, David, Alhamss, Abdelrahman, Alquthami, Khaled, Subudhi, Amit Kumar, Subudhi, Amit, Eric Volz, Sadhasivam Perumal, Asim Khogeer, Olga Douvropoulou, Jumana Taha, Anwar M. Hashem, Fathia Ben Rached, Luke Esau, Raeece Naeem, Huoming Zhang, Tobias Mourier, Khaled Alquthami, David Jorgensen, Abdelrahman Alhamss, Ahmed Mahmoud, Fadwa Alofi, Awad Al-Omari, Samer Salih, Qingtian Guan, Abbas Shamsan, Sara Mfarrej, Raushan Nugmanova, Abbas Al Mutair, Abdullah Dageeg, Sharif Hala, Amit Kumar Subudhi, Afrah Alsomali, Rahul P. Salunke, Naif Almontashiri, Abdulaziz Alahmadi, Amanda Ooi, Nashwa Khotani, Issaac Rajan, Paula Moraga, Arnab Pain, Muhammad Shuaib   +77 more
core   +1 more source

The Nucleocapsid Protein of Coronaviruses Acts as a Viral Suppressor of RNA Silencing in Mammalian Cells [PDF]

Journal of Virology, 2015
ABSTRACT RNA interference (RNAi) is a process of eukaryotic posttranscriptional gene silencing that functions in antiviral immunity in plants, nematodes, and insects. However, recent studies provided strong supports that RNAi also plays a role in antiviral mechanism in mammalian cells. To combat RNAi-mediated antiviral responses,
Lei, Cui, Haiying, Wang, Yanxi, Ji, Jie, Yang, Shan, Xu, Xingyu, Huang, Zidao, Wang, Lei, Qin, Po, Tien, Xi, Zhou, Deyin, Guo, Yu, Chen   +11 more
openaire   +2 more sources

Epstein–Barr virus tegument protein BGLF2 in exosomes released from virus-producing cells facilitates de novo infection

Cell Communication and Signaling, 2022
Background Viruses must adapt to the environment of their host cells to establish infection and persist. Diverse mammalian cells, including virus-infected cells, release extracellular vesicles such as exosomes containing proteins and miRNAs, and use ...
Yoshitaka Sato, Masahiro Yaguchi, Yusuke Okuno, Hanako Ishimaru, Ken Sagou, Somi Ozaki, Takeshi Suzuki, Tomoki Inagaki, Miki Umeda, Takahiro Watanabe, Masahiro Fujimuro, Takayuki Murata, Hiroshi Kimura   +12 more
doaj   +1 more source