Results 51 to 60 of about 4,116,626 (248)

Inhibition of glycogen synthase kinase-3-beta (GSK3β) blocks nucleocapsid phosphorylation and SARS-CoV-2 replication

Molecular Biomedicine, 2022
GSK3β has been proposed to have an essential role in Coronaviridae infections. Screening of a targeted library of GSK3β inhibitors against both SARS-CoV-2 and HCoV-229E to identify broad-spectrum anti-Coronaviridae inhibitors resulted in the ...
Tirosh Shapira, Selvarani Vimalanathan, Celine Rens, Virginia Pichler, Sandra Peña-Díaz, Grace Jordana, William Rees, Dirk F. H. Winkler, Iqbal Sarai, Theodore Steiner, François Jean, Steven Pelech, Yossef Av-Gay   +12 more
doaj   +1 more source

SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA [PDF]

, 2020
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes COVID-19, a pandemic that seriously threatens global health. SARS-CoV-2 propagates by packaging its RNA genome into membrane enclosures in host cells.
Amanda Jack, Luke S. Ferro, Michael J. Trnka, Eddie Wehri, Amrut Nadgir, Xammy Nguyenla, Katelyn Costa, Sarah Stanley, Julia Schaletzky, Ahmet Yildiz   +9 more
openaire   +4 more sources

The inhibitory effect of the hepatitis B virus singly-spliced RNA-encoded p21.5 protein on HBV nucleocapsid formation. [PDF]

PLoS ONE, 2015
Hepatitis B virus (HBV) is the smallest DNA virus and the major cause of acute and chronic hepatitis. The 3.2 kb HBV viral genome generates four major species of unspliced viral transcript as well as several alternatively spliced RNAs.
Yi-Ling Wang, Gan-Guang Liou, Chao-Hsiung Lin, Mong-Liang Chen, Tzer-Min Kuo, Kuen-Nan Tsai, Chien-Choao Huang, Ya-Ling Chen, Li-Rung Huang, Yu-Chi Chou, Chungming Chang   +10 more
doaj   +1 more source

PREHOST: Host prediction of coronaviridae family using machine learning

Heliyon, 2023
Coronavirus, a zoonotic virus capable of transmitting infections from animals to humans, emerged as a pandemic recently. In such circumstances, it is essential to understand the virus's origin.
Anusha Chaturvedi, Kushal Borkar, U Deva Priyakumar, P.K. Vinod   +3 more
doaj   +1 more source

Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism [PDF]

, 2013
Schmallenberg virus (SBV) is a newly emerged orthobunyavirus (family Bunyaviridae) that has caused severe disease in the offspring of farm animals across Europe.
Richard M. Elliott, Böttcher, Bettina, Li, P., Dong, H., Li, Ping, Dong, Changjiang, Dong, Haohao, Elliott, R., Boettcher, Bettina, Elliott, Richard M., Bottcher, B., Haohao Dong, Bettina Böttcher, Ping Li, Elliott, Richard M, Dong, C., Changjiang Dong   +16 more
core   +1 more source

Nucleocapsid formation and RNA synthesis of Marburg virus is dependent on two coiled coil motifs in the nucleoprotein

Virology Journal, 2007
The nucleoprotein (NP) of Marburg virus (MARV) is responsible for the encapsidation of viral genomic RNA and the formation of the helical nucleocapsid precursors that accumulate in intracellular inclusions in infected cells.
Lander Angelika, Möller Peggy, DiCarlo Andrea, Kolesnikova Larissa, Becker Stephan   +4 more
doaj   +1 more source

SARS-CoV-2 spike and nucleocapsid proteins fail to activate human dendritic cells or γδ T cells.

PLoS ONE, 2022
γδ T cells are thought to contribute to immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the mechanisms by which they are activated by the virus are unknown. Using flow cytometry, we investigated if the two most abundant
Kiran Singh, Sita Cogan, Stefan Elekes, Dearbhla M Murphy, Sinead Cummins, Rory Curran, Zaneta Najda, Margaret R Dunne, Gráinne Jameson, Siobhan Gargan, Seamus Martin, Aideen Long, Derek G Doherty   +12 more
doaj   +1 more source

Viral evolution identifies a regulatory interface between paramyxovirus polymerase complex and nucleocapsid that controls replication dynamics

, 2020
International audienceA protein interface between paramyxovirus polymerase and nucleocapsid is involved in regulating viral replication ...
Richard K. Plemper, Robert M. Cox, Julien Sourimant, Sourimant, Julien, Thakkar, Vidhi, Vidhi D. Thakkar, Plemper, Richard, Cox, Robert   +7 more
core   +1 more source

The Interaction between tRNA(Lys) 3 and the primer activation signal deciphered by NMR spectroscopy. [PDF]

PLoS ONE, 2013
The initiation of reverse transcription of the human immunodeficiency virus type 1 (HIV-1) requires the opening of the three-dimensional structure of the primer tRNA(Lys) 3 for its annealing to the viral RNA at the primer binding site (PBS).
Dona Sleiman, Pierre Barraud, Franck Brachet, Carine Tisne   +3 more
doaj   +1 more source

The Sendai Virus Matrix Protein Appears to be Recruited in the Cytoplasm by the Viral Nucleocapsid to function in Viral Assembly and Budding

Journal of General Virology, 1994
The matrix (M) protein is viewed as the regulator of paramyxovirus particle assembly and budding. Accordingly it was observed to be mutated, and/or decreased in amount, in cases where virus particle production was significantly reduced. Here, a non-productive [non-defective and defective interfering (DI)] Sendai virus infection of COS cells is ...
Stricker R, Mottet G, Roux L
openaire   +3 more sources