Results 71 to 80 of about 114,928,473 (245)

Kinase-anchoring proteins and the intracellular targeting of cyclic adenosine monophosphate (cAMP)-dependent protein kinase

, 2007
Kinase anchoring proteins (AKAPs) are a family of structurally diverse multidomain proteins classified solely by their ability to bind cAMP-dependent protein kinase/protein kinase A (PKA).
Alison Jane Davis (7656008)
core   +6 more sources

Loss of Akap1 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure

Frontiers in Physiology, 2018
Left ventricular hypertrophy (LVH) is a major contributor to the development of heart failure (HF). Alterations in cyclic adenosine monophosphate (cAMP)-dependent signaling pathways participate in cardiomyocyte hypertrophy and mitochondrial dysfunction ...
Gabriele G. Schiattarella, Nicola Boccella, Roberta Paolillo, Fabio Cattaneo, Fabio Cattaneo, Valentina Trimarco, Anna Franzone, Anna Franzone, Stefania D’Apice, Giuseppe Giugliano, Laura Rinaldi, Domenica Borzacchiello, Alessandra Gentile, Assunta Lombardi, Antonio Feliciello, Giovanni Esposito, Cinzia Perrino   +16 more
doaj   +1 more source

A guanosine 5′-triphosphate-dependent protein kinase is localized in the outer envelope membrane of pea chloroplasts [PDF]

, 1988
A guanosine 5-triphosphate (GTP)-dependent protein kinase was detected in preparations of outer chloroplast envelope membranes of pea (Pisum sativum L.) chloroplasts.
Soll, Jürgen, Keegstra, Kenneth, Fischer, Irene, Kenneth Keegstra, J�rgen Soll, Irene Fischer   +5 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei : the ethanolamine and choline kinases [PDF]

, 2008
Note related output below contains correction of this paper.Ethanolamine and choline are major components of the trypanosome membrane phospholipids, in the form of GPEtn (glycero-phosphoethanolamine) and GPCho (glycerophosphocholine).
Smith, Terry K., Gibellini, Federica, Smith, Terry K, Hunter, William N., Gibellini, F., Hunter, W. N., Hunter, William N   +6 more
core   +1 more source

An RNA Metabolism and Surveillance Quartet in the Major Histocompatibility Complex

Cells, 2019
At the central region of the mammalian major histocompatibility complex (MHC) is a complement gene cluster that codes for constituents of complement C3 convertases (C2, factor B and C4).
Danlei Zhou, Michalea Lai, Aiqin Luo, Chack-Yung Yu   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

A Kinase Anchor Protein 4 Is Vulnerable to Oxidative Adduction in Male Germ Cells

Frontiers in Cell and Developmental Biology, 2019
Oxidative stress is a leading causative agent in the defective sperm function associated with male infertility. Such stress commonly manifests via the accumulation of pathological levels of the electrophilic aldehyde, 4-hydroxynonenal (4HNE), generated ...
Brett Nixon, Brett Nixon, Ilana R. Bernstein, Ilana R. Bernstein, Shenae L. Cafe, Shenae L. Cafe, Maryse Delehedde, Nicolas Sergeant, Nicolas Sergeant, Amanda L. Anderson, Amanda L. Anderson, Natalie A. Trigg, Natalie A. Trigg, Andrew L. Eamens, Andrew L. Eamens, Tessa Lord, Tessa Lord, Matthew D. Dun, Matthew D. Dun, Geoffry N. De Iuliis, Geoffry N. De Iuliis, Elizabeth G. Bromfield, Elizabeth G. Bromfield, Elizabeth G. Bromfield   +23 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

How protein kinase inhibitors bind to the hinge region of the target protein. [PDF]

Structural Dynamics
The human genome encodes 518 protein kinases which make up one of the most important families of regulatory proteins, catalyzing phosphorylation of hydroxyl-containing amino acids, i.e. tyrosine, serine and threonine [1].
Urszula Derewenda, Steve Scheiner, Zygmunt S Derewenda   +2 more
doaj   +1 more source