Results 51 to 60 of about 82,113 (260)
MyRIP Anchors Protein Kinase A to the Exocyst Complex [PDF]
Journal of Biological Chemistry, 2007 The movement of signal transduction enzymes in and out of multi-protein complexes coordinates the spatial and temporal resolution of cellular events. Anchoring and scaffolding proteins are key to this process because they sequester protein kinases and phosphatases with a subset of their preferred substrates.
April S, Goehring +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Clonal variation in cell surface display of an H-2 protein lacking a cytoplasmic tail [PDF]
, 1986 Truncated variants of the gene encoding H-2Ld, an integral membrane protein encoded by the major histocompatibility complex, were constructed by in vitro mutagenesis to elucidate the function of charged amino acids found on the cytoplasmic side of the ...
Hood, Leroy E., Zuñiga, Martha C.
core
A Systematic Evaluation of Protein Kinase A–A-Kinase Anchoring Protein Interaction Motifs
Biochemistry, 2014 Protein kinase A (PKA) in vertebrates is localized to specific locations in the cell via A-kinase anchoring proteins (AKAPs). The regulatory subunits of the four PKA isoforms (RIα, RIβ, RIIα, and RIIβ) each form a homodimer, and their dimerization domain interacts with a small helical region present in each of the more than 40 AKAPs reported so far ...
Pepijn P. Burgers +4 more
openaire +4 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
A-kinase anchoring proteins and neuronal signaling mechanisms [PDF]
Genes & Development, 2003 The rapid and reversible phosphorylation of proteins catalyzed by protein kinases and protein phosphatases is a well recognized mechanism of regulation in cells. This bidirectional process is a highly flexible method of influencing cellular activity in response to a variety of incoming stimuli. A physiological role for protein phosphorylation was first
Graeme K, Carnegie, John D, Scott
openaire +2 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Defining the core proteome of the chloroplast envelope membranes [PDF]
, 2013 High-throughput protein localization studies require multiple strategies. Mass spectrometric analysis of defined cellular fractions is one of the complementary approaches to a diverse array of cell biological methods. In recent years, the protein content
Ibrahim, Mohamed +9 more
core +2 more sources
AKAPDB: A-Kinase Anchoring Proteins Database [PDF]
Genomics & Informatics, 2010 Abstract A-kinase-anchoring proteins (AKAPs) are scaffold pro-teins which compartmentalize protein kinase A (PKA, cAMP-dependent protein kinase) and other enzymes to specific subcellular sites. The spatiotemporal control of these enzymes by AKAPs is important for cellular func-tion like cell growth and development etc.
In-Sil Kim +4 more
openaire +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source