Results 31 to 40 of about 41,419 (260)

A-kinase anchoring proteins: scaffolding proteins in the heart

American Journal of Physiology-Heart and Circulatory Physiology, 2011
The pleiotropic cyclic nucleotide cAMP is the primary second messenger responsible for autonomic regulation of cardiac inotropy, chronotropy, and lusitropy. Under conditions of prolonged catecholaminergic stimulation, cAMP also contributes to the induction of both cardiac myocyte hypertrophy and apoptosis.
Diviani Dario, Dodge-Kafka Kimberly L, Li Jinliang, Kapiloff Michael S   +3 more
openaire   +4 more sources

Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton

Cell Reports
Summary: Ubiquitination is an essential regulator of cell division. The kinase Polo-like kinase 1 (PLK1) promotes protein degradation at G2/M phase through the E3 ubiquitin ligase Skp1-Cul1-F box (SCF)βTrCP.
Ryan D. Mouery, Kimberly Lukasik, Carolyn Hsu, Thomas Bonacci, Derek L. Bolhuis, Xianxi Wang, C. Allie Mills, E. Drew Toomer, Owen G. Canterbury, Kevin C. Robertson, Timothy B. Branigan, Nicholas G. Brown, Laura E. Herring, Stephanie L. Gupton, Michael J. Emanuele   +14 more
doaj   +1 more source

Regulation of the U3-, U8-, and U13snoRNA Expression by the DEAD Box Proteins Ddx5/Ddx17 with Consequences for Cell Proliferation and Survival

Non-Coding RNA, 2016
Small nucleolar RNAs (snoRNAs) in cooperation with their associated proteins (snoRNPs) contribute to the maturation of ribosomal RNA, transfer RNA, and other transcripts. Most snoRNPs mediate chemical base modifications of their RNA substrates, and a few
Hala Ismael, Simone Altmeyer, Hans Stahl
doaj   +1 more source

A-Kinase Anchoring Protein Targeting of Protein Kinase A and Regulation of HERG Channels [PDF]

Journal of Membrane Biology, 2008
Adrenergic stimulation of the heart initiates a signaling cascade in cardiac myocytes that increases the concentration of cAMP. Although cAMP elevation may occur over a large area of a target-organ cell, its effects are often more restricted due to local concentration of its main effector, protein kinase A (PKA), through A-kinase anchoring proteins ...
Li, Yan, Sroubek, Jakub, Krishnan, Yamini, McDonald, Thomas V.   +3 more
openaire   +2 more sources

IgaA negatively regulates the Rcs Phosphorelay via contact with the RcsD Phosphotransfer Protein.

PLoS Genetics, 2020
Two-component systems and phosphorelays play central roles in the ability of bacteria to rapidly respond to changing environments. In E. coli and related enterobacteria, the complex Rcs phosphorelay is a critical player in the bacterial response to ...
Erin A Wall, Nadim Majdalani, Susan Gottesman   +2 more
doaj   +1 more source

Encapsulating Cas9 into extracellular vesicles by protein myristoylation

Journal of Extracellular Vesicles, 2022
CRISPR/Cas9 genome editing is a very promising avenue for the treatment of a variety of genetic diseases. However, it is still very challenging to encapsulate CRISPR/Cas9 machinery for delivery.
Joseph Andrew Whitley, Sungjin Kim, Lei Lou, Chenming Ye, Omar Awad Alsaidan, Essilvo Sulejmani, Jingwen Cai, Ellison Gerona Desrochers, Zanna Beharry, Catherine Bowes Rickman, Mikael Klingeborn, Yutao Liu, Zhong‐Ru Xie, Houjian Cai   +13 more
doaj   +1 more source

A‐kinase anchoring proteins as potential drug targets [PDF]

British Journal of Pharmacology, 2012
A‐kinase anchoring proteins (AKAPs) crucially contribute to the spatial and temporal control of cellular signalling. They directly interact with a variety of protein binding partners and cellular constituents, thereby directing pools of signalling components to defined locales.
Jessica, Tröger, Marie C, Moutty, Philipp, Skroblin, Enno, Klussmann   +3 more
openaire   +2 more sources

PKA, PKC, and AKAP localization in and around the neuromuscular junction

BMC Neuroscience, 2001
Background One mechanism that directs the action of the second messengers, cAMP and diacylglycerol, is the compartmentalization of protein kinase A (PKA) and protein kinase C (PKC). A-kinase anchoring proteins (AKAPs) can recruit both enzymes to specific
Newton Alexandra, Smith Donelson, Violin Jonathan D, Barraclough David M, Deerinck Thomas J, Martone Maryann, Yao Virginia J, Humphries Kenneth, Huang Lily, Wang Lin, Perkins Guy A, Scott John D, Taylor Susan S, Ellisman Mark H   +13 more
doaj   +1 more source

A-Kinase Anchoring Proteins That Regulate Cardiac Remodeling [PDF]

Journal of Cardiovascular Pharmacology, 2011
In response to injury or stress, the adult heart undergoes maladaptive changes, collectively defined as pathological cardiac remodeling. Here, we focus on the role of A-kinase anchoring proteins (AKAPs) in 3 main areas associated with cardiac remodeling and the progression of heart failure: excitation-contraction coupling, sarcomeric regulation, and ...
Graeme K, Carnegie, Brian T, Burmeister
openaire   +2 more sources

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source