Results 31 to 40 of about 82,113 (260)

A-Kinase Anchoring Protein Targeting of Protein Kinase A and Regulation of HERG Channels [PDF]

Journal of Membrane Biology, 2008
Adrenergic stimulation of the heart initiates a signaling cascade in cardiac myocytes that increases the concentration of cAMP. Although cAMP elevation may occur over a large area of a target-organ cell, its effects are often more restricted due to local concentration of its main effector, protein kinase A (PKA), through A-kinase anchoring proteins ...
Li, Yan, Sroubek, Jakub, Krishnan, Yamini, McDonald, Thomas V.   +3 more
openaire   +2 more sources

The hepta-β-glucoside elicitor-binding proteins from legumes represent a putative receptor family [PDF]

, 2000
The ability of legumes to recognize and respond to β-glucan elicitors by synthesizing phytoalexins is consistent with the existence of a membrane-bound β-glucan-binding site.
Ebel, J., Fliegmann, J., Mithöfer, A., Neuhaus-Url, G., Schwarz, H.   +4 more
core   +1 more source

The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex. [PDF]

, 2019
The inner centromere is a region on every mitotic chromosome that enables specific biochemical reactions that underlie properties, such as the maintenance of cohesion, the regulation of kinetochores and the assembly of specialized chromatin, that can ...
A Chakraborty, A Jain, AE Kelly, AG Larson, AM Ainsztein, AR Strom, B Banerjee, B Bolognesi, BG Fuller, BR Sabari, E Niedzialkowska, E Wang, Enrico Gratton, Ewa Niedzialkowska, F Cardarelli, F Sessa, F Wang, Francesco Palomba, J Chen, J Du, JB Woodruff, JG Ruppert, K Jaqaman, KM Sathyan, KS Bloom, L Scipioni, M Delacour-Larose, M Wachsmuth, M Wühr, Michelle A. Digman, ML Hanley, MS Wheelock, P Trivedi, P Trivedi, P. Todd Stukenberg, PDJ Moens, Prasad Trivedi, R Mahen, RCC Hengeveld, S Ambadipudi, S Hauf, S Hindriksen, SC Sampath, SE Rosasco-Nitcher, SF Banani, Shasha Chong, SM Janicki, SP Wheatley, T Hirota, T Tsukahara, UR Klein, VA Beardmore, W Fischle, X Liu, Y Abe, Y Shin, Y Yamagishi, Y Yamagishi   +57 more
core   +2 more sources

Signal recognition particle binds to translating ribosomes before emergence of a signal anchor sequence. [PDF]

, 2017
The bacterial signal recognition particle (SRP) is part of the machinery that targets ribosomes synthesizing membrane proteins to membrane-embedded translocons co-translationally. Recognition of nascent membrane proteins occurs by virtue of a hydrophobic
Holtkamp, W., Mercier, E., Rodnina, M., Wintermeyer, W.   +3 more
core   +2 more sources

A‐kinase anchoring proteins as potential drug targets [PDF]

British Journal of Pharmacology, 2012
A‐kinase anchoring proteins (AKAPs) crucially contribute to the spatial and temporal control of cellular signalling. They directly interact with a variety of protein binding partners and cellular constituents, thereby directing pools of signalling components to defined locales.
Jessica, Tröger, Marie C, Moutty, Philipp, Skroblin, Enno, Klussmann   +3 more
openaire   +2 more sources

A-Kinase Anchoring Proteins That Regulate Cardiac Remodeling [PDF]

Journal of Cardiovascular Pharmacology, 2011
In response to injury or stress, the adult heart undergoes maladaptive changes, collectively defined as pathological cardiac remodeling. Here, we focus on the role of A-kinase anchoring proteins (AKAPs) in 3 main areas associated with cardiac remodeling and the progression of heart failure: excitation-contraction coupling, sarcomeric regulation, and ...
Graeme K, Carnegie, Brian T, Burmeister
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Anchored phosphatases modulate glucose homeostasis. [PDF]

, 2012
Endocrine release of insulin principally controls glucose homeostasis. Nutrient-induced exocytosis of insulin granules from pancreatic β-cells involves ion channels and mobilization of Ca(2+) and cyclic AMP (cAMP) signalling pathways.
Cirulli, Vincenzo, Dell'Acqua, Mark L, Hinke, Simon A, Jimenez-Caliani, Antonio J, Langeberg, Lorene K, Navedo, Manuel F, Nygren, Patrick J, Santana, L Fernando, Scott, John D, Tengholm, Anders, Tian, Geng, Ulman, Allison, Whiting, Jennifer L   +12 more
core   +1 more source