Results 31 to 40 of about 114,928,473 (245)

Generation of an arrhythmogenic right ventricular cardiomyopathy-patient-derived iPS cell line with PKP2 and AKAP9 mutation (MUNIi022-A)

Stem Cell Research
We have established an iPSC cell line carrying mutations in Plakophillin 2 (PKP2) and the A-kinase anchor protein 9 (AKAP9). Plakophilin 2 is an important protein of desmosomes, facilitating cell attachment and tissue strength.
Deborah Beckerová, Anezka Polachova, Petra Komorníková, Martin Pesl, Eva Makaturová, Blanka Robešová, Tamara Jankovičová, Jitka Kadlecová, Hana Poloczkova, Vladimir Rotrekl   +9 more
doaj   +1 more source

Fragile X Mental Retardation Protein positively regulates PKA anchor Rugose and PKA activity to control actin assembly in learning/memory circuitry

Neurobiology of Disease, 2019
Recent work shows Fragile X Mental Retardation Protein (FMRP) drives the translation of very large proteins (>2000 aa) mediating neurodevelopment.
James C. Sears, Woong Jae Choi, Kendal Broadie   +2 more
doaj   +1 more source

Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton

Cell Reports
Summary: Ubiquitination is an essential regulator of cell division. The kinase Polo-like kinase 1 (PLK1) promotes protein degradation at G2/M phase through the E3 ubiquitin ligase Skp1-Cul1-F box (SCF)βTrCP.
Ryan D. Mouery, Kimberly Lukasik, Carolyn Hsu, Thomas Bonacci, Derek L. Bolhuis, Xianxi Wang, C. Allie Mills, E. Drew Toomer, Owen G. Canterbury, Kevin C. Robertson, Timothy B. Branigan, Nicholas G. Brown, Laura E. Herring, Stephanie L. Gupton, Michael J. Emanuele   +14 more
doaj   +1 more source

Regulation of the U3-, U8-, and U13snoRNA Expression by the DEAD Box Proteins Ddx5/Ddx17 with Consequences for Cell Proliferation and Survival

Non-Coding RNA, 2016
Small nucleolar RNAs (snoRNAs) in cooperation with their associated proteins (snoRNPs) contribute to the maturation of ribosomal RNA, transfer RNA, and other transcripts. Most snoRNPs mediate chemical base modifications of their RNA substrates, and a few
Hala Ismael, Simone Altmeyer, Hans Stahl
doaj   +1 more source

Glycosylation can influence topogenesis of membrane proteins and reveals dynamic reorientation of nascent polypeptides within the translocon [PDF]

, 1999
The topology of multispanning membrane proteins in the mammalian endoplasmic reticulum is thought to be dictated primarily by the first hydrophobic sequence.
Martin Spiess, Veit Goder, Goder, V., Spiess, M., Christoph Bieri, Bieri, C.   +5 more
core   +1 more source

Encapsulating Cas9 into extracellular vesicles by protein myristoylation

Journal of Extracellular Vesicles, 2022
CRISPR/Cas9 genome editing is a very promising avenue for the treatment of a variety of genetic diseases. However, it is still very challenging to encapsulate CRISPR/Cas9 machinery for delivery.
Joseph Andrew Whitley, Sungjin Kim, Lei Lou, Chenming Ye, Omar Awad Alsaidan, Essilvo Sulejmani, Jingwen Cai, Ellison Gerona Desrochers, Zanna Beharry, Catherine Bowes Rickman, Mikael Klingeborn, Yutao Liu, Zhong‐Ru Xie, Houjian Cai   +13 more
doaj   +1 more source

IgaA negatively regulates the Rcs Phosphorelay via contact with the RcsD Phosphotransfer Protein.

PLoS Genetics, 2020
Two-component systems and phosphorelays play central roles in the ability of bacteria to rapidly respond to changing environments. In E. coli and related enterobacteria, the complex Rcs phosphorelay is a critical player in the bacterial response to ...
Erin A Wall, Nadim Majdalani, Susan Gottesman   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts [PDF]

, 2004
The endothelins are a family of endothelium-derived peptides that possess a variety of functions, including vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and promotes myofibroblast contraction and migration, hence ...
Abraham, DJ, du Bois, R M, Denton, CP, Black, C M, Chen, YL, Chen, Y L, Chen, Y, Shi-Wen, X., Renzoni, E.A., Denton, C P, Shi-Wen, X, Leask, A., Pearson, J D, Xu, SW, Bou-Gharios, George, du Bois, RM, Xu, S W, Dashwood, M, Denton, C.P., Bou-Gharios, G., Renzoni, E A, Pearson, JD, Chen, Y., Abraham, D.J., Abraham, D J, Renzoni, EA, Black, CM, Dashwood, M., Eastwood, M, Leask, A, Eastwood, M., Black, C.M., Pearson, J., du Bois, R., Bou-Gharios, G   +34 more
core   +1 more source

PKA, PKC, and AKAP localization in and around the neuromuscular junction

BMC Neuroscience, 2001
Background One mechanism that directs the action of the second messengers, cAMP and diacylglycerol, is the compartmentalization of protein kinase A (PKA) and protein kinase C (PKC). A-kinase anchoring proteins (AKAPs) can recruit both enzymes to specific
Newton Alexandra, Smith Donelson, Violin Jonathan D, Barraclough David M, Deerinck Thomas J, Martone Maryann, Yao Virginia J, Humphries Kenneth, Huang Lily, Wang Lin, Perkins Guy A, Scott John D, Taylor Susan S, Ellisman Mark H   +13 more
doaj   +1 more source