Results 21 to 30 of about 41,419 (260)
Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance Dissemination of chemical information throughout the cell is a fundamental biological process with clinical relevance. Pathological changes in local signaling enzyme activity are linked to diseases, including schizophrenia, Alzheimer’s disease, cardiac arrhythmias, and seizures.
F. Donelson Smith +14 more
openaire +4 more sources
A dynamic interface between ubiquitylation and cAMP signaling
Frontiers in Pharmacology, 2015 Phosphorylation waves drive the propagation of signals generated in response to hormones and growth factors in target cells. cAMP is an ancient second messenger implicated in key biological functions. In mammals, most of the effects elicited by cAMP are
Laura eRinaldi +3 more
doaj +1 more source
RACK1 regulates neural development
Neural Regeneration Research, 2017 Receptor for activated C kinase 1 (RACK1) is an evolutionarily conserved scaffolding protein within the tryptophan-aspartate (WD) repeat family of proteins.
Leah Kershner, Kristy Welshhans
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 With the ability to switch between proliferative and contractile phenotype, airway smooth muscle (ASM) cells can contribute to the progression of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), in which airway obstruction
Hoeke A. Baarsma +13 more
doaj +1 more source
High Concentrations of Atmospheric Ammonia Induce Alterations in the Hepatic Proteome of Broilers (Gallus gallus): An iTRAQ-Based Quantitative Proteomic Analysis. [PDF]
PLoS ONE, 2015 With the development of the poultry industry, ammonia, as a main contaminant in the air, is causing increasing problems with broiler health. To date, most studies of ammonia toxicity have focused on the nervous system and the gastrointestinal tract in ...
Jize Zhang +5 more
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Detection and characterization of protein interactions in vivo by a simple live-cell imaging method. [PDF]
PLoS ONE, 2013 Over the last decades there has been an explosion of new methodologies to study protein complexes. However, most of the approaches currently used are based on in vitro assays (e.g.
Oriol Gallego +5 more
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Frontiers in Medicine, 2022 PurposeKeratoconus (KC) is a corneal ectasia characterized by structural changes, resulting in progressive thinning and biomechanical weakening that can lead to worsening visual acuity due to irregular astigmatism. Corneal collagen Crosslinking (CXL) and
Nahia Goñi +9 more
doaj +1 more source
eLife, 2018 We use the myotendinous junction of Drosophila flight muscles to explore why many integrin associated proteins (IAPs) are needed and how their function is coordinated.
Hannah J Green +3 more
doaj +1 more source
HMMerThread: detecting remote, functional conserved domains in entire genomes by combining relaxed sequence-database searches with fold recognition. [PDF]
PLoS ONE, 2011 Conserved domains in proteins are one of the major sources of functional information for experimental design and genome-level annotation. Though search tools for conserved domain databases such as Hidden Markov Models (HMMs) are sensitive in detecting ...
Charles Richard Bradshaw +4 more
doaj +1 more source
Neurobiology of Disease, 2019 Recent work shows Fragile X Mental Retardation Protein (FMRP) drives the translation of very large proteins (>2000 aa) mediating neurodevelopment.
James C. Sears +2 more
doaj +1 more source