Results 21 to 30 of about 114,928,473 (245)

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome [PDF]

, 2012
Previous work has shown that the protein kinase A (PKA)–regulated phosphodiesterase (PDE) 4D3 binds to A kinase–anchoring proteins (AKAPs). One such protein, AKAP9, localizes to the centrosome.
Stangherlin, A, Surdo, N. C., Terrin, A., Sawa, A., Terrin, A, N. E. Jordanides, A. Stangherlin, Monterisi, S, Mountford, JC, Monterisi, S., A. Terrin, Surdo, NC, Stefania Monterisi, Akira Sawa, Mongillo, M, Jordanides, NE, Alessandra Stangherlin, Koschinski, A, Manuela Zaccolo, Joanne C. Mountford, Nicoletta C. Surdo, Niove E. Jordanides, Jordanides, N..E., Anna Zoccarato, Koschinski, A., Zaccolo, Manuela, MONGILLO, MARCO, Andreas Koschinski, Anna Terrin, M. Zaccolo, Sawa, A, A. Koschinski, A. Zoccarato, Zoccarato, A., Zaccolo, M., A. Sawa, Mountford, J.C., Zoccarato, A, N. C. Surdo, Marco Mongillo, Stangherlin, A., Mongillo, M., S. Monterisi, J. C. Mountford   +43 more
core   +1 more source

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins [PDF]

, 2013
Signaling through G proteins normally involves conformational switching between GTP- and GDP-bound states. Several Rho GTPases are also regulated by RhoGDI binding and sequestering in the cytosol.
Riou, P, Parker, Peter J., O’Reilly, N., George, Roger, Ritu Garg, McColl, Brad, Ganka Bineva, Kjær, S., Svend Kjær, Garg, R, Bineva, G., Thompson, AJ, Reymond, N, Thompson, Andrew J., Philippe Riou, Purkiss, Andrew, Nicola O’Reilly, Parker, Peter J, Brad McColl, Peter J. Parker, Neil Q. McDonald, Parker, Peter J.; id_orcid, O’Reilly, Nicola, Riou, P., Purkiss, A, Parker, PJ, Thompson, A.J., McColl, B, Cain, RJ, Parker, P.J., Kjær, Svend, McColl, B., Andrew Purkiss, O’Reilly, N, Kjær, S, Garg, R., Garg, Ritu, O'Reilly, Nicola, Anne J. Ridley, Cain, Robert J, Robert J. Cain, McDonald, Neil Q, Ridley, Anne J, Bineva, G, Ridley, A.J., Purkiss, Andrew G., Nicolas Reymond, George, R., Thompson, Andrew J, Reymond, N., Reymond, Nicolas, Cain, Robert J., Bineva, Ganka, McDonald, NQ, Riou, Philippe, Andrew J. Thompson, Ridley, AJ, Kjaer, Svend, George, R, Cain, R.J., Ridley, Anne J., Roger George, McDonald, Neil Q.   +62 more
core   +1 more source

RACK1 regulates neural development

Neural Regeneration Research, 2017
Receptor for activated C kinase 1 (RACK1) is an evolutionarily conserved scaffolding protein within the tryptophan-aspartate (WD) repeat family of proteins.
Leah Kershner, Kristy Welshhans
doaj   +1 more source

Disruption of AKAP-PKA Interaction Induces Hypercontractility With Concomitant Increase in Proliferation Markers in Human Airway Smooth Muscle

Frontiers in Cell and Developmental Biology, 2020
With the ability to switch between proliferative and contractile phenotype, airway smooth muscle (ASM) cells can contribute to the progression of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), in which airway obstruction
Hoeke A. Baarsma, Hoeke A. Baarsma, Bing Han, Bing Han, Wilfred J. Poppinga, Wilfred J. Poppinga, Saskia Driessen, Carolina R. S. Elzinga, Andrew J. Halayko, Herman Meurs, Herman Meurs, Harm Maarsingh, Martina Schmidt, Martina Schmidt   +13 more
doaj   +1 more source

High Concentrations of Atmospheric Ammonia Induce Alterations in the Hepatic Proteome of Broilers (Gallus gallus): An iTRAQ-Based Quantitative Proteomic Analysis. [PDF]

PLoS ONE, 2015
With the development of the poultry industry, ammonia, as a main contaminant in the air, is causing increasing problems with broiler health. To date, most studies of ammonia toxicity have focused on the nervous system and the gastrointestinal tract in ...
Jize Zhang, Cong Li, Xiangfang Tang, Qingping Lu, Renna Sa, Hongfu Zhang   +5 more
doaj   +1 more source

Detection and characterization of protein interactions in vivo by a simple live-cell imaging method. [PDF]

PLoS ONE, 2013
Over the last decades there has been an explosion of new methodologies to study protein complexes. However, most of the approaches currently used are based on in vitro assays (e.g.
Oriol Gallego, Tanja Specht, Thorsten Brach, Arun Kumar, Anne-Claude Gavin, Marko Kaksonen   +5 more
doaj   +1 more source

Tear proteome profile in eyes with keratoconus after intracorneal ring segment implantation or corneal crosslinking

Frontiers in Medicine, 2022
PurposeKeratoconus (KC) is a corneal ectasia characterized by structural changes, resulting in progressive thinning and biomechanical weakening that can lead to worsening visual acuity due to irregular astigmatism. Corneal collagen Crosslinking (CXL) and
Nahia Goñi, Nahia Goñi, Itziar Martínez-Soroa, Itziar Martínez-Soroa, Oliver Ibarrondo, Mikel Azkargorta, Felix Elortza, David J. Galarreta, Arantxa Acera, Arantxa Acera   +9 more
doaj   +1 more source

Control of PKA stability and signalling by RING ligase praja2 [PDF]

, 2010
Ligand-mediated activation of G-Protein Coupled Receptors (GPCRs) mobilises compartmentalised pulses of second messengers like cAMP. The main cellular effector of cAMP is Protein Kinase A (PKA) which is assembled as inactive holoenzyme consisting of two ...
Lignitto, Luca
core   +1 more source

Novel functions for integrin-associated proteins revealed by analysis of myofibril attachment in Drosophila

eLife, 2018
We use the myotendinous junction of Drosophila flight muscles to explore why many integrin associated proteins (IAPs) are needed and how their function is coordinated.
Hannah J Green, Annabel GM Griffiths, Jari Ylänne, Nicholas H Brown   +3 more
doaj   +1 more source

HMMerThread: detecting remote, functional conserved domains in entire genomes by combining relaxed sequence-database searches with fold recognition. [PDF]

PLoS ONE, 2011
Conserved domains in proteins are one of the major sources of functional information for experimental design and genome-level annotation. Though search tools for conserved domain databases such as Hidden Markov Models (HMMs) are sensitive in detecting ...
Charles Richard Bradshaw, Vineeth Surendranath, Robert Henschel, Matthias Stefan Mueller, Bianca Hermine Habermann   +4 more
doaj   +1 more source