Mitochondrial a Kinase Anchor Proteins in Cardiovascular Health and Disease: A Review Article on Behalf of the Working Group on Cellular and Molecular Biology of the Heart of the Italian Society of Cardiology [PDF]
International Journal of Molecular Sciences, 2022 Gabriele G Schiattarella +2 more
exaly +2 more sources
A-kinase-anchoring proteins [PDF]
Journal of Cell Science, 2004 Highly organized molecular complexes determine the precise location and timing of the signal transduction events that occur downstream of cell surface receptor activation ([Pawson and Nash, 2003][1]). One set of scaffolding molecules that organize such complexes is a family of proteins known as A-
Lorene K, Langeberg, John D, Scott
openaire +2 more sources
Protein Kinase A Anchoring [PDF]
Journal of Biological Chemistry, 1997 Specificity is perhaps the most enigmatic property of hormonemediated signaling pathways, especially when one considers that more than 30 hormones employ the ubiquitous second messengers, Ca, phospholipid, or cAMP, to relay messages from the cell membrane to intracellular effectors.
M L, Dell'Acqua, J D, Scott
openaire +2 more sources
A-Kinase Anchoring Proteins [PDF]
Circulation, 2010 The heart is a sophisticated organ that continuously pumps blood to ensure that oxygen and nutrients reach the brain, other organs, and peripheral tissue. The right side of the heart pumps blood to the lungs, where oxygen is taken up and carbon dioxide is removed.
John D, Scott, Luis F, Santana
openaire +2 more sources
A-kinase anchoring proteins take shape [PDF]
Current Opinion in Cell Biology, 2007 A-kinase anchoring proteins (AKAPs) are signaling scaffolds that contribute to various aspects of cAMP signaling. They do this by tethering protein kinase-A to specific subcellular sites, thereby focusing its activity toward relevant substrates.
Darren L, Beene, John D, Scott
openaire +2 more sources
Anchoring proteins encounter mitotic kinases [PDF]
Cell Cycle, 2013 Defective progression of cells through mitosis permits an accumulation of genetic defects that lead to aneuploidy. Cells in a state of aneuploidy acquire mutations that eventually cause their transformation from normal cells into cancer.1 Recent evidence suggests that perturbing the spatial and temporal pattern of cell division can enhance such ...
Canton, David A., Scott, John D.
openaire +2 more sources
Cypher/ZASP Is a Novel A-kinase Anchoring Protein [PDF]
Journal of Biological Chemistry, 2013 PKA signaling is important for the post-translational modification of proteins, especially those in cardiomyocytes involved in cardiac excitation-contraction coupling. PKA activity is spatially and temporally regulated through compartmentalization by protein kinase A anchoring proteins.
Lin, Changsong +13 more
openaire +4 more sources
Lessons from LIMK1 enzymology and their impact on inhibitor design [PDF]
, 2019 LIM domain kinase 1 (LIMK1) is a key regulator of actin dynamics. It is thereby a potential therapeutic target for the prevention of fragile X syndrome and amyotrophic lateral sclerosis.
Beltrami, A +10 more
core +2 more sources
Stimulation of a glycosyl-phosphatidylinositol-specific phospholipase by insulin and the sulfonylurea, glimepiride, in rat adipocytes depends on increased glucose transport [PDF]
, 1994 . Lipoprotein lipase (LPL) and glycolipidanchored cAMP-binding ectoprotein (Gcel) are modified by glycosyl-phosphatidylinositol (GPI) in rat adipocytes, however, the linkage is potentially unstable. Incubation of the cells with either insulin (0.1-30 nM)
Bandlow, Wolfhard +3 more
core +3 more sources
Animal cell cytokinesis: the role of dynamic changes in the plasma membrane proteome and lipidome [PDF]
, 2016 In animal cells, cytokinesis is characterised by the formation of the mitotic spindle that signals the assembly of an actomyosin ring between the spindle poles.
Gould, Gwyn W.
core +2 more sources