A Michaelis-Arbuzov-Type Pathway to a Protected 2'-Deoxy-2'-Selenomethyl-Adenosine-3',5'-Phosphoroselenolate Guanosine Dinucleotide for Use in Modified m7G Cap Synthesis. [PDF]
ChemistryHere we report a synthesis of the dinucleotide 4 for a projected future total synthesis of the m7G cap 1. Highlights of the route include: 1) a 3ʹ‐H‐phosphonate/5ʹ‐selenocyanate Michaelis‐Arbuzov coupling to forge the 3ʹ,5ʹ‐phosphoroselenolate; 2) an Amosova reductive selenomethylation to install the 2ʹ‐SeMe; 3) a solid CPR II 5ʹ‐O‐phosphitylation; and
Hale KLE, McCarthy HO, McLaughlin MG.
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Back to the Electrofuture: Named Reactions Powered by Electroorganic Syntheses. [PDF]
ChemSusChemBridging classical named reactions with modern electroorganic chemistry, this review presents how electrochemical strategies can revive and reinterpret historically significant transformations, highlighting their emerging potential as sustainable alternatives in contemporary organic synthesis.
Maiti D, Heo Y, Kang G, Kim M, Choi I.
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Self-Assembly of a Customizable Library of Nickel Trifluoromethylation Catalysts via Selective C─F and C─O Bond Cleavage. [PDF]
Angew Chem Int Ed EnglCarbatranes and anionic pincer ligands were self‐assembled via one‐pot C─F or C─O bond cleavage and the formation of C─O, C─N, or C─C bonds, forming ligand architectures inaccessible by common synthetic methods. This approach allowed to build a customizable library of nickel catalysts for light‐induced C─H bond trifluoromethylation.
Sorvanov A +5 more
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Dynamics of Clinical Manifestations and Social Functioning in Schizophrenia: A Non-interventional Observational Study of Paliperidone Palmitat Dosage Forms [PDF]
Consortium PsychiatricumBACKGROUND: Over the past seven years, the use of long-acting forms of antipsychotic medication has significantly increased in Russia. Specifically, in Moscow, from 2016 to 2021, the proportion of prescribed injectable long-acting antipsychotics had ...
Aleksandr M. Reznik +17 more
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Crystals, 2021 Two polymorphic forms of a conformationally flexible molecule, 5-[(Diphenylphosphoryl)methyl]-4-(prop-2-en-1-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione, were obtained by crystallization and characterized by X-ray diffraction analysis and differential ...
Ivan V. Fedyanin +4 more
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Thymine-Modified Nanocarrier for Doxorubicin Delivery in Glioblastoma Cells
Molecules, 2023 Brain tumor glioblastoma is one of the worst types of cancer. The blood–brain barrier prevents drugs from reaching brain cells and shields glioblastoma from treatment.
Albina Y. Ziganshina +10 more
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Diethyl 1-(N-acetylamino)-1-(diphenylphosphinoyl)-1-phenylmethylphosphonate
Molbank, 2022 Diethyl 1-(N-acetylamino)-1-(diphenylphosphinoyl)-1-phenylmethylphosphonate was synthesized at room temperature, starting from 1-ethoxy derivative of diethyl 1-(N-acetylamino)-1-phenylmethylphosphonate via the corresponding phosphonium salt as a reactive
Anna Kuźnik +2 more
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Beilstein Journal of Organic Chemistry, 2021 A new method for C–N bond transformations into C–P bonds was developed using 1,2,3-triazoles as leaving groups in SNAr–Arbuzov reactions. A series of C6-phosphonated 2-triazolylpurine derivatives was synthesized for the first time, with the isolated ...
Kārlis-Ēriks Kriķis +3 more
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Asymmetrically Substituted s‐Triazine Phosphonates by One‐Step Synthesis
ChemistryOpen, 2023 Asymmetrically substituted s‐triazine phosphonates with up to three different phosphonate groups C3N3RR'R” with R, R’, R”=PO(OR”’) and R”’=for example, methyl, ethyl, isopropyl or n‐butyl are interesting as polymer additives like flame retardants ...
Claudia Vogt +5 more
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FACILITATION OF CHORUS ROLE IN A. N. ARBUZOV’S PARABLE “THE HAPPY DAYS OF AN UNHAPPY MAN” [PDF]
Philology. Theory & Practice, 2018 The article is devoted to the analysis of the facilitated image of the chorus and its functions in the parable “The Happy Days of an Unhappy Man”, which was written by the Soviet playwright A. N. Arbuzov in 1967. It is proved that in the play the playwright simplifies the role of the chorus, facilitates its presence on the stage.
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