Results 91 to 100 of about 25,494 (296)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Culturally-Tailored Smoking Cessation for American Indians: Study protocol for a randomized controlled trial

Trials, 2011
Background Cigarette smoking is the number one cause of preventable death among American Indian and Alaska Natives, AI/ANs. Two out of every five AI/AN will die from tobacco-related diseases if the current smoking rates of AI/ANs (40.8%) persist ...
Shireman Theresa I, Yeh Hung-Wen, Greiner Allen K, Beebe Laura A, Faseru Babalola, Choi Won S, Talawyma Myrietta, Cully Lance, Kaur Baljit, Daley Christine M   +9 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Comparison of Mobilizing and Immobilizing Splints on Hand Motor Function in Stroke Patients: A Randomize Clinical Trial

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2012
<p><strong><em>Background and Objectives:</em></strong><strong> </strong>Among several methods for the treatment of wrist-fingers motor function impairment after stroke, splinting is a method commonly used as ...
M Heydari
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Effects of Recitation of Holy Quran on Anxiety of Women before Cesarean Section: A Randomize Clinical Trial

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2012
<p><strong><em>Background and Objectives:</em> </strong>Anxiety is a kind of agitation and concern stemming from the feeling of threat or hazard in human. It can decrease or increase the understanding ability of individuals.
N Mir Bagher AjorPaz
doaj  

In pursuit of balance : randomization in practice in development field experiments [PDF]

Randomized experiments are increasingly used in development economics, with researchers now facing the question of not just whether to randomize, but how to do so.
Bruhn, Miriam, McKenzie, David
core  

User oriented access to secure biomedical resources through the grid [PDF]

, 2006
The life science domain is typified by heterogeneous data sets that are evolving at an exponential rate. Numerous post-genomic databases and areas of post-genomic life science research have been established and are being actively explored. Whilst many of
Ajayi, O., Jiang, J., Sinnott, R.O., Stell, A.J., Watt, J.   +4 more
core   +3 more sources

Rerandomization to improve covariate balance in experiments

, 2012
Randomized experiments are the "gold standard" for estimating causal effects, yet often in practice, chance imbalances exist in covariate distributions between treatment groups.
Morgan, Kari Lock, Rubin, Donald B.
core   +1 more source