Results 31 to 40 of about 895,970 (238)

Gürcü Rüyası Partisi: “Yabancı Ajan” Yasa Tasarısının AB ile İlişkiler Kapsamında Değerlendirilmesi

Akademik İncelemeler Dergisi
Küresel düzenin “soğuk” büyük güçlerinden olan SSCB 1991’de resmen dağıldığında siyaset bilimi akademisi, post komünist devletlerde başlayan demokratikleşme sürecinin heyecanıyla liberal siyasetin zaferini ilan ettiler.
Seda Kaya Karabulut
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Comparative Study on Antibacterial Efficacy, Hydroxyapatite Crystal, Fluoride Release and Microleakage in Bioactive Restorative Materials

Journal of Pharmacy and Bioallied Sciences
Background: The newer concept of A-BA is gaining more and more attention as newer smart dental material helps in rebuilding demineralized dentin. Aim: To evaluate ABE, HA-CG, FR, and ML in BA restorative material.
Sonali Waghmode, Ranu S. Ingole, Savita Hadakar, Prajakta Gaikwad, Ajay Kumar Dogra, Suman Gulia   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Arap Baharı Sonrası Avrupa Birliği'nin Yeni Komşuluk Politikasi

Mukaddime, 2018
Özet Orta Doğu ve Kuzey Afrika’da 2010 yılında ortaya çıkan halk isyan dalgaları, AB’nin Güney Akdeniz ülkeleriyle ilişkilerini komşuluk politikası bağlamında yeniden düzenlemesine neden olmuştur.
Zelal Başak Kızılkan
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Exposure to CuO Nanoparticles Mediates NFκB Activation and Enhances Amyloid Precursor Protein Expression

Biomedicines, 2020
Amyloid precursor protein (APP) is directly related to Aβ amyloidosis—a hallmark of Alzheimer’s disease (AD). However, the impact of environmental factors upon APP biology and Aβ amyloid pathology have not been well studied.
Xiaoyang Mou, Alexander Pilozzi, Breeya Tailor, Jing Yi, Catherine Cahill, Jack Rogers, Xudong Huang   +6 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

United Nations Convention on Law of Sea as a Mixed Treaty of EU: A headache for Turkey?

Ankara Avrupa Çalışmaları Dergisi, 2013
Avrupa Birliği tarafından akdedilmiş uluslararası anlaşmalar ve andlaşmalar acquis communautaire yani AB müktesebatının bir parçasını teşkil etmektedir.
Ulas Gündüzler
doaj   +1 more source