Results 51 to 60 of about 5,075,322 (256)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

abs

, 2022
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openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Kerr-Schild metrics revisited II. The complete vacuum solution

, 2002
The complete solution of Einstein's gravitational equations with a vacuum-vacuum Kerr-Schild pencil of metrics $g_{ab}+V l_al_b$ is obtained. Our result generalizes the solution of the Kerr-Schild problem with a flat metric $g_{ab}$ (represented by the ...
László Á. Gergely, Thompson A. H., Zoltán Perjés   +2 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Exposure to CuO Nanoparticles Mediates NFκB Activation and Enhances Amyloid Precursor Protein Expression

Biomedicines, 2020
Amyloid precursor protein (APP) is directly related to Aβ amyloidosis—a hallmark of Alzheimer’s disease (AD). However, the impact of environmental factors upon APP biology and Aβ amyloid pathology have not been well studied.
Xiaoyang Mou, Alexander Pilozzi, Breeya Tailor, Jing Yi, Catherine Cahill, Jack Rogers, Xudong Huang   +6 more
doaj   +1 more source

Temperature dependence and anisotropy of the bulk upper critical field H_c2 of MgB_2

, 2002
The bulk upper critical field H_{c2}(T) of superconducting MgB_2 and its anisotropy are established by analyzing experimental data on the temperature and magnetic field dependences of the ab-plane thermal conductivity of a single-crystalline sample in ...
Jun, J., Karpinski, J., Kazakov, S. M., Ott, H. R., Sologubenko, A. V.   +4 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Avrupa Birliği Uyum Sürecinde Bölgesel Kalkınma Politikaları: Bölgesel Kalkınma Ajansları ve Türkiye Uygulaması

Akademik İncelemeler Dergisi, 2014
1974’te Avrupa Bölgesel Kalkınma Fonlarının oluşturulmasından sonra zaman içerisinde şekillenen AB bölgesel politikaları 1990 sonrasında AB üyeliği için başvuruda bulunan ülkeler için üyelik öncesi uyum sürecinde ilerleme kaydedilmesi gereken ...
Aziz Tuncer, Bilal Eryılmaz
doaj  

Media Ownership Concentration and Pluralism In The European Union: An Assessment Within The Framework Of EMFA

Erciyes İletişim Dergisi
Media ownership concentration threatens media freedom and pluralism by enabling economic and political influence over editorial decisions and information flow.
Canan Özcan, Vedat Çakır
doaj   +1 more source