Results 61 to 70 of about 447,015 (283)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Bulletin de l'Institut Français d'Études Andines, 2013 We analyzed two archaeological sites occupied during the fifteenth century A.D., located in the Hualfín Valley (Catamarca. Argentina). Excavations in these sites provided evidence of massive fires.
María Celeste Valencia +1 more
doaj +1 more source
The Mississippian fin de siècle in the middle Cumberland region of Tennessee [PDF]
, 2018 Bayesian chronological modeling is used to investigate the chronology for a large-scale human depopulation event during the Mississippian period (AD 1000–1600) known as the Vacant Quarter phenomenon.
Cobb, Charles R., Krus, Anthony M.
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Holistic assessment of call centre performance
IET Networks, 2017 In modern call centres 60–70% of the operational costs come in the form of the human agents who take the calls. Ensuring that the call centre operates at lowest cost and maximum efficiency involves a trade‐off of the cost of agents against lost revenue ...
Edward A. Smith, John A. Schormans
doaj +1 more source
Effectively Preserving Philadelphia's Workforce Housing Stock [PDF]
, 2009 Compares home repair costs with the consequences of residential abandonment. Calls for expanded Basic Systems Repair Programs and deferred loans to help those unable to afford repairs, code enforcement, targeted and integrated funding, and ...
Karen Black
core
The Dynamic Effects of Subconscious Goal Pursuit on Resource Allocation, Task Performance, and Goal Abandonment [PDF]
, 2015 We test two potential boundary conditions for the effects of subconscious goals—the nature of the goal that is activated (achievement vs. underachievement) and conscious goal striving. Subconscious achievement goals increase the amount of time devoted to
Bell, Bradford S, Sitzmann, Traci
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Wellhead Tieback Technology for Shallow Sea Well under Integrated Exploration-development Strategy
Shiyou jixie, 2018 According to relevant laws and regulations, at the end of well life, the exploratory well will either be permanently abandoned or temporary abandoned. The permanent abandonment requirement is stricter than the temporary abandonment.
Huo Hongbo +6 more
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