Results 211 to 220 of about 24,586 (301)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz   +8 more
wiley   +1 more source

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar   +6 more
wiley   +1 more source

AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence

open access: yesBritish Journal of Pharmacology, EarlyView.
Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi   +10 more
wiley   +1 more source

<i>Brucella</i> Infections in Camels and Abattoir Workers in the United Arab Emirates: One Health-Based Seroepidemiological and Molecular Insights. [PDF]

open access: yesTransbound Emerg Dis
Ameni G   +16 more
europepmc   +1 more source

How important are within‐occupation task changes for wage growth? Evidence from administrative micro data

open access: yesEconomica, EarlyView.
We examine how changes in task content over time condition occupational wage development. Using survey data from Germany, we document substantial heterogeneity in within‐occupation changes in task content. Combining this evidence with administrative data on individual employment outcomes over a 25‐year period, we find important heterogeneity in wage ...
Ronald Bachmann   +3 more
wiley   +1 more source

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