Results 221 to 230 of about 67,131 (272)

Photo‐Triggered, Fast, and Fluorogenic Thiophene‐Based Cycloalkynes for the Bioorthogonal Fluorescent Labeling of 1,3‐Dipole‐Tagged Molecules in No‐Wash Conditions

Angewandte Chemie, EarlyView.
Thiophene is king! The fusion of thiophene rings to cycloalkynes super‐charged their copper‐free click chemistry applications, by (1) enhancing the alkyne reactivity (fastest cyclooctyne to date) and (2) rendering the alkyne fluorogenic (with fluorescence enhancement up to 150‐fold upon reaction), making these bioorthogonal reagents ideal for tracking ...
Jurgen Schulz, Zoeisha S. Chinoy, Tarek Khalaf, Yukang Li, Pengchen Ma, Dennis Svatunek, Kendall N. Houk, Frédéric Friscourt   +7 more
wiley   +2 more sources

Intraindividual cognitive variability predicts amyloid beta, tau PET, and dementia conversion in Down syndrome: a potential marker of cognitive resilience. [PDF]

Alzheimers Dement
Fonseca LM, Lila E, Shojaie A, Chhatwal J, Forlenza O, Beeri MS, Krinsky-McHale S, Cohen AD, Christian BT, Head E, Mapstone M, Handen B, Ances BM, Grabowski T, Chaytor NS, Zaman S, Alzheimer's Biomarkers Consortium‐ Down Syndrome (ABC‐DS) Investigators.   +16 more
europepmc   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Targeting of ibrutinib resistance-driving pathways by miR-28 in ABC-DLBCL. [PDF]

Leukemia
Álvarez-Corrales E, Moreno-Palomares R, Gómez-Escolar C, Martínez M, Moral-Pérez U, Laguna-Herrero M, Fuertes T, Estrada BS, Mur S, de Bonis A, Leiva M, Martínez-Martín N, Somoza Á, Ramiro AR, de Yébenes VG.   +14 more
europepmc   +1 more source

Human Leukocyte Elastase Triggered Nanoparticles for Targeted Antimicrobial Delivery and Oral Microbial Modulation

Advanced NanoBiomed Research, EarlyView.
This study explores enzyme‐responsive nanoparticles for targeted antimicrobial release in inflamed oral environments. Nanoparticles formed by complexing peptides and chlorhexidine respond to human leukocyte elastase and release chlorhexidine selectively. P7 (ECAAPVCE)‐based formulations show optimal properties and stability, with antimicrobial activity
Mohammed A. Hadis, Ignacio Insua, Farah N. S. Raja, Álvaro Vila, William M. Palin, Michael R. Milward, Paul R. Cooper, Sarah A. Kuehne, Owen Addison, Paco Fernandez‐Trillo   +9 more
wiley   +1 more source

Significance of RGS13 expression in lupus B cells. [PDF]

PLoS One
Nakajima T, Kitagori K, Funakoshi S, Shirakashi M, Hiwa R, Tsuji H, Akizuki S, Nakashima R, Morinobu A, Yoshifuji H.   +9 more
europepmc   +1 more source

The Dual Role of Methyl Caffeate: Growth Inhibition of Pseudomonas syringae and Induction of Resistance to Bacterial Speck Disease in Tomato. [PDF]

Mol Plant Pathol
Yang Y, Yu J, Yang J, Wang Y, Hou W, Zhang D, Wang J, Nie W, Zhang Y, Wang X, Li X, Shi Q.   +11 more
europepmc   +1 more source

Metagenomic sequencing reveals structural and functional differentiation of rhizosphere bacterial communities driven by nitrogen and potassium deficiency associated with root rot of <i>Schisandra chinensis</i>. [PDF]

Front Microbiol
Li L, Liu R, Yang H, Zhao Y.
europepmc   +1 more source

PEG Alternatives in Liposomal Nanocarriers: Physicochemical Characteristics and Sustainable Process Strategies

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The global trend toward sustainable and intensified bioprocesses is driving innovation in the design and scalable synthesis of liposomal nanocarriers, a cornerstone of modern drug delivery. For decades, these nanosystems have relied exclusively on polyethylene glycol (PEG) for their sustained circulation in vivo, but they are currently ...
Chandra Has
wiley   +1 more source