Results 51 to 60 of about 3,829,561 (285)

ABC transporters: Lessons from a bacterial oligopeptide uptake system [PDF]

, 2006
ABC transporters are proteins that are involved in the uptake of nutrients and excretion of harmful substances in biological cells. Defects in human ABC transporters can result in severe diseases.
Doeven, Mark Koop,, Doeven, Mark Koop
core   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

On Topological Indices for New Classes of Benes Network

Journal of Mathematics, 2021
Topological indices (TIs) transform a molecular graph into a number. The TIs are a vital tool for quantitative structure activity relationship (QSAR) and quantity structure property relationship (QSPR).
Aftab Hussain, Muhammad Numan, Nafisa Naz, Saad Ihsan Butt, Adnan Aslam, Asfand Fahad   +5 more
doaj   +1 more source

Performance of the ABC-bleeding risk score for assessing major bleeding risk in Chinese patients with atrial fibrillation on oral anticoagulation therapy: A real-world study

Frontiers in Cardiovascular Medicine, 2022
ObjectiveTo evaluate performance of the ABC (Age, Biomarkers, Clinical history)-bleeding risk score in estimating major bleeding risk in Chinese patients with atrial fibrillation (AF) on oral anticoagulation (OAC) therapy in real-world practice ...
Yu-Feng Wang, Chao Jiang, Liu He, Cun-Ying Pu, Xin Du, Xin Du, Xin Du, Cai-Hua Sang, De-Yong Long, Ri-Bo Tang, Jian-Zeng Dong, Jian-Zeng Dong, Chang-Sheng Ma   +12 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

A Hybrid of Artificial Bee Colony, Genetic Algorithm, and Neural Network for Diabetic Mellitus Diagnosing

ARO-The Scientific Journal of Koya University, 2018
Researchers, widely have introduced the Artificial Bee Colony (ABC) as an optimization algorithm to deal with classification, and prediction problems.
Tarik A. Rashid, Saman M. Abdullah
doaj   +1 more source

Inflammation Induces Changes in the Functional Expression of P-gp, BCRP, and MRP2: An Overview of Different Models and Consequences for Drug Disposition

Pharmaceutics, 2021
The ATP-binding cassette (ABC) transporters play a key role in drug pharmacokinetics. These membrane transporters expressed within physiological barriers can be a source of pharmacokinetic variability.
Sonia Saib, Xavier Delavenne
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Tools and Techniques for Implementing ABC/ABM [PDF]

, 2001
P(論文)ABC、ABCM、およびABMの概念はどのように異なるか。ABC/ABM実施の7段階とは何か。ABC/ABM実施の各段階に有用なツールと手法とは何か。本稿ではこのような問題について実証研究の知見を参考にして考察してみた。This article reflects on following topics refering to SMA NO.
飯塚, 勲, 27987
core