Results 71 to 80 of about 4,295,538 (284)

Inflammation Induces Changes in the Functional Expression of P-gp, BCRP, and MRP2: An Overview of Different Models and Consequences for Drug Disposition

Pharmaceutics, 2021
The ATP-binding cassette (ABC) transporters play a key role in drug pharmacokinetics. These membrane transporters expressed within physiological barriers can be a source of pharmacokinetic variability.
Sonia Saib, Xavier Delavenne
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Activities-specific balance confidence scale in elderly in community nursing home

Environmental Disease, 2023
Background: To investigate the incidence of falls in elderly in nursing homes and to determine the differences in confidence indexes of daily living in the Activities-Specific Balance Confidence Scale (ABC) in elderly fallers or nonfallers.
Jing Feng, Yuchuan Ding, Lipeng Cai, Enoch Kim, Pan Gu, Zhaohui Song, Huimin Fan, Xiaokun Geng   +7 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

On the Trees With Maximal Augmented Zagreb Index

IEEE Access, 2018
The augmented Zagreb index (AZI), a variant of the well-known atom-bond connectivity (ABC) index, was shown to have the best predicting ability for a variety of physicochemical properties among several tested vertex-degree-based topological indices ...
Wenshui Lin, Akbar Ali, Linshan Huang, Zhixi Wu, Jianfeng Chen   +4 more
doaj   +1 more source

Accurate fundamental parameters of CoRoT asteroseismic targets: the solar-like stars HD 49933, HD 175726, HD 181420 and HD 181906

, 2009
The CoRoT satellite has provided high-quality light curves of several solar-like stars. Analysis of the light curves provides oscillation frequencies that make it possible to probe the interior of the stars.
Alcock, Andersen, Appourchaux, Bessell, Bruntt, Bruntt, Cenarro, Christensen-Dalsgaard, Clausen, Collet, Frankowski, Gillon, Grevesse, Gustafsson, H. Bruntt, Hauck, Heiter, Kjeldsen, Kovtyukh, Kovtyukh, Kupka, Makarov, Martell, Masana, Mayor, Michel, Mosser, Mosser, Nordström, North, North, Petrov, Pietrinferni, Ramírez, Rentzsch-Holm, Rogers, Solano, Stello, Valenti, van Leeuwen   +39 more
core   +3 more sources

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

General Relativistic Scalar Field Models in the Large

, 1994
For a class of scalar fields including the massless Klein-Gordon field the general relativistic hyperboloidal initial value problems are equivalent in a certain sense. By using this equivalence and conformal techniques it is proven that the hyperboloidal
Accioly A J, Andersson L, Andersson L, Ashtekar A, Bekenstein J D, Bekenstein J D, Choptuik M W, Christodoulou D, Christodoulou D, Friedrich H, Friedrich H, Friedrich H, Friedrich H, Friedrich H, Friedrich H, Friedrich H, Friedrich H, Geroch R, Hawking S W, Hübner P, Hübner P, Klimcík C, Penrose R, Penrose R, Peter Hübner, Wald R M   +25 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source