Results 51 to 60 of about 6,585 (184)

Additional file 7 of Inhibition of ABCC9 by zinc oxide nanoparticles induces ferroptosis and inhibits progression, attenuates doxorubicin resistance in breast cancer

, 2022
Additional file 7: Fig. S7. ABCC9 overexpression counteracts ZON-inhibited viability and proliferation of Dox-resistant cell. The MDA-MB-231/Dox and MDA-MB-468/Dox cells were transfected with ABCC9 overexpressing vectors, and treated with erastin and ZON.
Shuang Li (146392), Zhe Fan (10730754), Yang Li (7082), Xiaoxue Zhang (1755322), Long Chen (315739), Zhixuan Liao (11996508), Qiang Zhang (45005), Cui Jiang (7362659), Shunxiong Tang (9949870)   +8 more
core   +1 more source

Additional file 2 of Inhibition of ABCC9 by zinc oxide nanoparticles induces ferroptosis and inhibits progression, attenuates doxorubicin resistance in breast cancer

, 2022
Additional file 2: Fig. S2.
Shuang Li (146392), Zhe Fan (10730754), Yang Li (7082), Xiaoxue Zhang (1755322), Long Chen (315739), Zhixuan Liao (11996508), Qiang Zhang (45005), Cui Jiang (7362659), Shunxiong Tang (9949870)   +8 more
core   +1 more source

Additional file 3 of Inhibition of ABCC9 by zinc oxide nanoparticles induces ferroptosis and inhibits progression, attenuates doxorubicin resistance in breast cancer

, 2022
Additional file 3: Fig. S3. Ferrostatin reverses ABCC9 depletion-induced ferroptosis of BC cells. (A-G) The MDA-MB-231 and MDA-MB-468 cells were treated with ABCC9 shRNA and ferrostatin (1 mmol/L).
Shuang Li (146392), Zhe Fan (10730754), Yang Li (7082), Xiaoxue Zhang (1755322), Long Chen (315739), Zhixuan Liao (11996508), Qiang Zhang (45005), Cui Jiang (7362659), Shunxiong Tang (9949870)   +8 more
core   +1 more source

Kir6.1- and SUR2-dependent KATP overactivity disrupts intestinal motility in murine models of Cantú syndrome

JCI Insight, 2020
Cantú syndrome (CS), caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunit genes, is frequently accompanied by gastrointestinal (GI) dysmotility, and we ...
Nathaniel W. York, Helen Parker, Zili Xie, David Tyus, Maham Akbar Waheed, Zihan Yan, Dorothy K. Grange, Maria Sara Remedi, Sarah K. England, Hongzhen Hu, Colin G. Nichols   +10 more
doaj   +1 more source

Histone deacetylase inhibitors modulate KATP subunit transcription in HL-1 cardiomyocytes through effects on cholesterol homeostasis

Frontiers in Pharmacology, 2015
Histone deacetylase inhibitors (HDIs) are under investigation for the treatment of a number of human health problems. HDIs have proven therapeutic value in refractory cases of cutaneous T-cell lymphoma,.
Naheed eFatima, Devin C Cohen, Gauthaman eSukumar, Tristan M Sissung, James F Schooley, Mark C Haigney, William C Claycomb, Rachel T Cox, Clifton Lee Dalgard, Susan E. Bates, Thomas P Flagg   +10 more
doaj   +1 more source

Genetic polymorphisms are associated with individual susceptibility to dexmedetomidine

Frontiers in Genetics, 2023
Introduction: Dexmedetomidine (DXM) is widely used as an adjuvant to anesthesia or a sedative medicine, and differences in individual sensitivity to the drug exist.
Yuanyuan Ding, Aiqing Liu, Yafeng Wang, Shuai Zhao, Shiqian Huang, Hongyu Zhu, Lulin Ma, Linlin Han, Shaofang Shu, Lidong Zheng, Xiangdong Chen   +10 more
doaj   +1 more source

Multiple vascular anomalies and refractory pericardial effusion in a young patient with Cantu syndrome: a case report and review of the literature

BMC Pediatrics, 2023
Background Cantu syndrome is a rare and complex multisystem disorder characterized by hypertrichosis, facial dysmorphism, osteochondroplasia and cardiac abnormalities.
Falastine Daas, Punita Gupta, Fuad Kiblawi   +2 more
doaj   +1 more source

TDP-43 proteinopathy in aging: Associations with risk-associated gene variants and with brain parenchymal thyroid hormone levels

Neurobiology of Disease, 2019
TDP-43 proteinopathy is very prevalent among the elderly (affecting at least 25% of individuals over 85 years of age) and is associated with substantial cognitive impairment.
Peter T. Nelson, Zsombor Gal, Wang-Xia Wang, Dana M. Niedowicz, Sergey C. Artiushin, Samuel Wycoff, Angela Wei, Gregory A. Jicha, David W. Fardo   +8 more
doaj   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, Volume 183, Issue 12, Page 3213-3233, June 2026.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

Spectrum of Rare and Common Genetic Variants in Arrhythmogenic Cardiomyopathy Patients

Biomolecules, 2022
Arrhythmogenic cardiomyopathy (ACM) is a rare inherited disorder, whose genetic cause is elusive in about 50–70% of cases. ACM presents a variable disease course which could be influenced by genetics. We performed next-generation sequencing on a panel of
Melania Lippi, Mattia Chiesa, Ciro Ascione, Matteo Pedrazzini, Saima Mushtaq, Davide Rovina, Daniela Riggio, Anna Maria Di Blasio, Maria Luisa Biondi, Giulio Pompilio, Gualtiero I. Colombo, Michela Casella, Valeria Novelli, Elena Sommariva   +13 more
doaj   +1 more source