Results 1 to 10 of about 5,649 (130)

Sulfonylurea receptors and ATP-sensitive K+ channels in clonal pancreatic alpha cells. Evidence for two high affinity sulfonylurea receptors

Journal of Biological Chemistry, 1993
We tested for the presence of sulfonylurea receptors in pancreatic alpha cells. Two high affinity sulfonylurea receptors were identified in clonal pancreatic alpha cells (alpha TC-6): a 140-kDa species observed previously in clonal pancreatic beta cells (HIT) and a second 150-kDa protein.
L Aguilar-Bryan, Colin G Nichols
exaly   +3 more sources

Multivalent activation of GLP-1 and sulfonylurea receptors modulates β-cell second-messenger signaling and insulin secretion

American Journal of Physiology - Cell Physiology, 2019
Nathaniel J Hart, Klearchos K Papas, Sean W Limesand   +2 more
exaly   +2 more sources

Effects of Sulfonylureas on Peroxisome Proliferator-Activated Receptor γ Activity and on Glucose Uptake by Thiazolidinediones [PDF]

Diabetes & Metabolism Journal, 2011
BackgroundSulfonylurea primarily stimulates insulin secretion by binding to its receptor on the pancreatic β-cells. Recent studies have suggested that sulfonylureas induce insulin sensitivity through peroxisome proliferator-activated receptor γ (PPARγ ...
Kyeong Won Lee, Yun Hyi Ku, Min Kim, Byung Yong Ahn, Sung Soo Chung, Kyong Soo Park   +5 more
doaj   +1 more source

The effects of incretin mimetics on the level of the microbial metabolite trimethylamine-N-oxide, a marker of cardiovascular risk in type 2 diabetic patients

Mìžnarodnij Endokrinologìčnij Žurnal, 2023
Background. The purpose was to investigate the effect of therapy with glucagon-like peptide-1 receptor agonists (GLP-1ra) on the serum concentration of trimethylamine-N-­oxide (TMAO), an intestinal microbiome metabolite, in patients with type 2 diabetes ...
K.O. Shyshkan-Shyshova, O.V. Zinych, N.M. Кushnareva, A.V. Кovalchuk, О.V. Prybyla   +4 more
doaj   +1 more source

Type 2 diabetes therapy at the time of diagnosis. Glimepiride: property, efficiency, safety

Сахарный диабет, 2009
В клинической практике имеется эффективный сахароснижающий препарат Амарил, обеспечивающий хороший контроль гликемии при однократном приеме, способствующий снижению массы тела, не имеющий побочных действий, обладающий экстрапанкреатическим ...
Olga Mikhailovna Smirnova
doaj   +1 more source

Transmembrane Topology of the Sulfonylurea Receptor SUR1 [PDF]

Journal of Biological Chemistry, 2001
Sulfonylurea receptors (SURx) are multi-spanning transmembrane proteins of the ATP-binding cassette (ABC) family, which associate with Kir6.x to form ATP-sensitive potassium channels. Two models, with 13-17 transmembrane segments, have been proposed for SURx topologies.
L R, Conti, C M, Radeke, S L, Shyng, C A, Vandenberg   +3 more
openaire   +2 more sources

An endogenous ligand for the central sulfonylurea receptor [PDF]

FEBS Letters, 1988
An endogenous ligand for the rat central sulfonylurea receptor has been evidenced in the rat central nervous system. The characteristics of this ligand (extractibility, non‐dialysability, chromatographic behaviour on different media, sensitivity to proteases) indicate that it is a neutral to slightly basic peptide.
Virsolvy-Vergine, A., Brück, M., Dufour, M., Cauvin, A., Lupo, B., Bataille, D.   +5 more
openaire   +2 more sources

The ATPase activities of sulfonylurea receptor 2A and sulfonylurea receptor 2B are influenced by the C‐terminal 42 amino acids [PDF]

The FEBS Journal, 2010
Unusually among ATP‐binding cassette proteins, the sulfonylurea receptor (SUR) acts as a channel regulator. ATP‐sensitive potassium channels are octameric complexes composed of four pore‐forming Kir6.2 subunits and four regulatory SUR subunits. Two different genes encode SUR1 (ABCC8) and SUR2 (ABCC9), with the latter being differentially spliced to ...
de Wet, H, Fotinou, C, Amad, N, Dreger, M, Ashcroft, F   +4 more
openaire   +6 more sources

Optimization of therapy of type 2 diabetes mellitus with the oral hypoglycemic agent glimepiride

Сахарный диабет, 2010
Type 2 diabetes is believed to develop as a result of lowered insulin secretion and insulin resistance leading to hyperglycemia. Sulfonylureas stimulateinsulin secretion and thereby decrease blood glucose level which accounts for their wide application ...
Tatiana Ivanovna Romantsova, Nadezhda Viktorovna Maksimova   +1 more
doaj   +1 more source

Investigation of Extrapancreatic Effects of Glipizide, A Second Generation Sulfonylurea Drug, by Using Insulin Clearance and Euglycaemic Clamp Technique

Endocrinology Research and Practice, 2022
The mechanism of the hypoglycaemic action of sulfonylurea agents remains controversial, in spite of the fact that they have been widely used in the clinical management of patients with NIDDM. in this study, we used insulin clearance and euglycaemic clamp
Ahmet Gökhan Özgen, Füsun Hamulu, Fırat Bayraktar, Şevki Çetinkalp, H. Yüceyar, Taylan Kabalak, Candeğer Yılmaz, Mehmet Tüzün   +7 more
doaj   +2 more sources