Results 1 to 10 of about 1,076,274 (226)

Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels [PDF]

Frontiers in Physiology
Ion channels play a pivotal role in regulating cellular excitability and signal transduction processes. Among the various ion channels, G-protein-coupled inwardly rectifying potassium (GIRK) channels serve as key mediators of neurotransmission and ...
Paul Slesinger, Ian Glaaser
exaly   +4 more sources

Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels [PDF]

Veterinarski Glasnik, 2016
Resveratrol is a phytoalexin produced in a number of plant species including grapes. The benefit of resveratrol to health is widely reported. Resveratrol has been found to promote relaxation of non-pregnant and pregnant uterus, but its mechanism
Novaković Radmila, Radunović Nebojša, Rajković Jovana, Đokić Vladimir, Petrović Aleksandar, Ivković Branka, Ćupić Vitomir, Kanjuh Vladimir, Heinlev Helmut, Gojković-Bukarica Ljiljana   +9 more
doaj   +4 more sources

Inwardly rectifying potassium channels: Critical insights for insect species and Apis mellifera [PDF]

Channels
Kir (inwardly rectifying potassium) channels that play key roles in maintaining potassium homeostasis, neuronal excitability, and osmoregulation have been cloned and characterized in a variety of insects.
Fabien Sourisseau, Craig A. Doupnik, Pierre Charnet, Mohamed Chahine   +3 more
doaj   +2 more sources

Cholesterol intake and statin use regulate neuronal G protein-gated inwardly rectifying potassium channels

Journal of Lipid Research, 2019
Cholesterol, a critical component of the cellular plasma membrane, is essential for normal neuronal function. Cholesterol content is highest in the brain, where most cholesterol is synthesized de novo; HMG-CoA reductase controls the synthesis rate ...
Paul S Blank, Anna Bukiya, Avia Rosenhouse-Dantsker   +2 more
exaly   +3 more sources

Cryo-EM structures of heteromeric Kir4.1/5.1 channel suggest mechanisms of inward rectification and channel blockage [PDF]

Nature Communications
Inwardly rectifying potassium (Kir) channels play key roles in regulating membrane potential and potassium transport through voltage-dependent inhibition by cytoplasmic Mg²⁺ and polyamines.
Yingjie Ning, Xiaoyu Zhou, Yimin Zhang, Nanhao Chen, Qianbei Guo, Chenxia Gu, Didi Xu, Ran Cui, Jiayi Wang, Mengdan Li, Dongxue Yang, Chen Song, Jie Yu, Zhaobing Gao, Jingpeng Ge   +14 more
doaj   +2 more sources

Engineered tRNA reduces vision loss in a mouse model of Leber congenital amaurosis [PDF]

Signal Transduction and Targeted Therapy
Premature termination codons (PTCs) are a major class of pathogenic variants that underlie rare inherited disorders, including forms of childhood blindness.
Pawan K. Shahi, Enes Akyuz, Lionel Gissot, Ahmad Al Saneh, Sanjai K. Pillala, Divya Sinha, Giovanni M. Hanstad, Meha Kabra, Maria A. Fernandez Zepeda, David M. Gamm, Samuel M. Young, Christopher A. Ahern, Bikash R. Pattnaik   +12 more
doaj   +2 more sources

Role of Astrocytic Inwardly Rectifying Potassium (Kir) 4.1 Channels in Epileptogenesis

Frontiers in Neurology, 2020
Astrocytes regulate potassium and glutamate homeostasis via inwardly rectifying potassium (Kir) 4.1 channels in synapses, maintaining normal neural excitability.
Masato Kinboshi, Masato Kinboshi, Akio Ikeda, Yukihiro Ohno   +3 more
doaj   +1 more source

The Relevance of GIRK Channels in Heart Function

Membranes, 2022
Among the large number of potassium-channel families implicated in the control of neuronal excitability, G-protein-gated inwardly rectifying potassium channels (GIRK/Kir3) have been found to be a main factor in heart control. These channels are activated
Ana Campos-Ríos, Lola Rueda-Ruzafa, José Antonio Lamas   +2 more
doaj   +1 more source

Computational Insights Into Voltage Dependence of Polyamine Block in a Strong Inwardly Rectifying K+ Channel

Frontiers in Pharmacology, 2020
Inwardly rectifying potassium (KIR) channels play important roles in controlling cellular excitability and K+ ion homeostasis. Under physiological conditions, KIR channels allow large K+ influx at potentials negative to the equilibrium potential of K ...
Xingyu Chen, Michael Bründl, Theres Friesacher, Anna Stary-Weinzinger   +3 more
doaj   +1 more source

Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels. [PDF]

PLoS ONE, 2013
G protein-gated inwardly rectifying potassium (GIRK) channels play an important role in regulating neuronal excitability. Sorting nexin 27b (SNX27b), which reduces surface expression of GIRK channels through a PDZ domain interaction, contains a putative ...
Bartosz Balana, Laia Bahima, Karthik Bodhinathan, Jaume J Taura, Natalie M Taylor, Margaret Y Nettleton, Francisco Ciruela, Paul A Slesinger   +7 more
doaj   +1 more source