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Inwardly rectifying potassium channels
Current Opinion in Cell Biology, 1999 Inwardly rectifying potassium (Kir) channels regulate the resting membrane potential of the cell and thereby modulate the electrical activity of cardiac and neuronal cells, insulin secretion and epithelial K(+) transport. Considerable progress in understanding the molecular structure of Kir channels and the way in which they are regulated by ...
Frank Reimann, Frances M Ashcroft
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Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels [PDF]
Frontiers in PhysiologyIon channels play a pivotal role in regulating cellular excitability and signal transduction processes. Among the various ion channels, G-protein-coupled inwardly rectifying potassium (GIRK) channels serve as key mediators of neurotransmission and ...
Paul A Slesinger, Slesinger Paul A
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Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels [PDF]
Veterinarski Glasnik, 2016 Resveratrol is a phytoalexin produced in a number of plant species including grapes. The benefit of resveratrol to health is widely reported. Resveratrol has been found to promote relaxation of non-pregnant and pregnant uterus, but its mechanism
Novaković Radmila +9 more
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Inwardly rectifying potassium channels: Critical insights for insect species and Apis mellifera [PDF]
ChannelsKir (inwardly rectifying potassium) channels that play key roles in maintaining potassium homeostasis, neuronal excitability, and osmoregulation have been cloned and characterized in a variety of insects.
Fabien Sourisseau +3 more
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Transmembrane Structure of an Inwardly Rectifying Potassium Channel [PDF]
Cell, 1999 Inwardly rectifying potassium channels (K(ir)), comprising four subunits each with two transmembrane domains, M1 and M2, regulate many important physiological processes. We employed a yeast genetic screen to identify functional channels from libraries of K(ir) 2.1 containing mutagenized M1 or M2 domains.
Daniel L Minor +2 more
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Journal of Lipid Research, 2019 Cholesterol, a critical component of the cellular plasma membrane, is essential for normal neuronal function. Cholesterol content is highest in the brain, where most cholesterol is synthesized de novo; HMG-CoA reductase controls the synthesis rate ...
Anna N Bukiya, Avia Rosenhouse-Dantsker
exaly +3 more sources
Engineered tRNA reduces vision loss in a mouse model of Leber congenital amaurosis [PDF]
Signal Transduction and Targeted TherapyPremature termination codons (PTCs) are a major class of pathogenic variants that underlie rare inherited disorders, including forms of childhood blindness.
Pawan K. Shahi +12 more
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Role of Astrocytic Inwardly Rectifying Potassium (Kir) 4.1 Channels in Epileptogenesis
Frontiers in Neurology, 2020 Astrocytes regulate potassium and glutamate homeostasis via inwardly rectifying potassium (Kir) 4.1 channels in synapses, maintaining normal neural excitability.
Masato Kinboshi +3 more
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The Relevance of GIRK Channels in Heart Function
Membranes, 2022 Among the large number of potassium-channel families implicated in the control of neuronal excitability, G-protein-gated inwardly rectifying potassium channels (GIRK/Kir3) have been found to be a main factor in heart control. These channels are activated
Ana Campos-Ríos +2 more
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Frontiers in Pharmacology, 2020 Inwardly rectifying potassium (KIR) channels play important roles in controlling cellular excitability and K+ ion homeostasis. Under physiological conditions, KIR channels allow large K+ influx at potentials negative to the equilibrium potential of K ...
Xingyu Chen +3 more
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